Chromatid structure: relationship between DNA content and nucleotide sequence diversity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1971-12

AUTHORS

Charles D. Laird

ABSTRACT

Models of chromatid structure are based on inferences made from genetic, cytological, and cytochemical observations. An alternative approach can provide limits as to the number of identical subunits present in chromatids. This method is based on the demonstration that nucleotide sequence diversity may be estimated from the kinetics of renaturation of denatured DNA. Measurements of DNA content and renaturation rate constants are given for several eukaryotic DNAs. Control experiments involved measurements of renaturation kinetics of DNAs from bacteria and bacteriophage. These estimates show that most of the nucleotide sequences in mouse, Drosophila, and Ciona DNA are present only once per sperm. Since the reduction of DNA content during meiosis indicates that mouse sperm contain a haploid set of chromatids, it follows that a set of mouse meiotic chromatids contains a single copy of most sequences. Models of chromatid structure which postulate multiple subunits with identical nucleotide sequences are therefore not tenable for mouse meiotic chromatids. This method of analyzing nucleotide sequence diversity may be of general use in designing models of chromatid structure in other organisms. More... »

PAGES

378-406

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00285251

DOI

http://dx.doi.org/10.1007/bf00285251

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027660762

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4995642


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