The H-Y antigen and its role in natural transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1981-08

AUTHORS

Rupert E. Billingham, Ingrid M. Hings

ABSTRACT

A concise overview of the transplantation biology of the H-Y antigen is presented with particular reference to: its prototypic behavior as a weak transplantation antigen; the facility with which mice of certain inbred strains can be rendered tolerant of H-Y incompatible skin grafts; its capacity to instigate graft-versus-host reactions; its significance in clinical transplantation; and finally, H-2 control of anti-H-Y immune responses.The role of the H-Y antigen in natural transplantation, i.e. pregnancy, is then reviewed. Evidence is presented to support the hypothesis that in certain cases maternal immune responses directed specifically to the H-Y antigen can exert selective pressures on male zygotes, producing deviant sex ratios in certain experimental and clinical situations. More... »

PAGES

9-17

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00284141

DOI

http://dx.doi.org/10.1007/bf00284141

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007179186

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7026417


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216 rdf:type schema:Organization
 




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