Type 1 (insulin-dependent) diabetes and a highly variable locus close to the insulin gene on chromosome 11 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1985-04

AUTHORS

G. A. Hitman, A. C. Tarn, R. M. Winter, V. Drummond, L. G. Williams, N. I. Jowett, G. F. Bottazzo, D. J. Galton

ABSTRACT

A polymorphic DNA sequence in the 5'-flanking region of the human insulin gene was studied in relation to Type 1 (insulin-dependent) diabetes. In 141 Caucasoid subjects analysed by Southern blot hybridisation techniques, two major DNA insertions were observed: a Class 1 allele or a Class 3 allele. The Class 2 allele was not observed in this group of subjects. Genotype frequencies in a control population (n = 88) were: homozygous 1/1, 42%; heterozygous 1/3, 50%; and homozygous 3/3, 8%. Corresponding genotype frequencies in 53 Type 1 diabetic patients were 79%, 21% and 0%, respectively (p less than 0.0005 from chi 2 test). This confirms prevalence data reported by Bell et al. [16]. There appeared to be no coinheritance with HLA-DR3/DR4 related antigens, nor with autoimmune features. Analysis of 17 Type 1 diabetic pedigrees including 34 diabetic and 69 non-diabetic subjects did not demonstrate genetic linkage of these DNA inserts with diabetes, using an autosomal recessive, single locus model of inheritance. More... »

PAGES

218-222

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00282236

DOI

http://dx.doi.org/10.1007/bf00282236

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050345818

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2991052


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, 6-12 and X", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Transposable Elements", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Linkage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HLA-DR Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histocompatibility Antigens Class II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pedigree", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Royal London Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416041.6", 
          "name": [
            "Departments of Diabetes, Lipids and Immunogenetics, St. Bartholomew's Hospital, London", 
            "The Medical Unit, The London Hospital, El, Whitechapel, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hitman", 
        "givenName": "G. A.", 
        "id": "sg:person.01150426603.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150426603.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St Bartholomew's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416353.6", 
          "name": [
            "Departments of Diabetes, Lipids and Immunogenetics, St. Bartholomew's Hospital, London"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tarn", 
        "givenName": "A. C.", 
        "id": "sg:person.0744243751.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744243751.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northwick Park Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416568.8", 
          "name": [
            "Division of Inherited Metabolic Diseases, Northwick Park Hospital, Harrow"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Winter", 
        "givenName": "R. M.", 
        "id": "sg:person.0752125673.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752125673.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St Bartholomew's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416353.6", 
          "name": [
            "Departments of Diabetes, Lipids and Immunogenetics, St. Bartholomew's Hospital, London"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Drummond", 
        "givenName": "V.", 
        "id": "sg:person.01157633546.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157633546.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St Bartholomew's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416353.6", 
          "name": [
            "Departments of Diabetes, Lipids and Immunogenetics, St. Bartholomew's Hospital, London"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Williams", 
        "givenName": "L. G.", 
        "id": "sg:person.01231725375.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231725375.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St Bartholomew's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416353.6", 
          "name": [
            "Departments of Diabetes, Lipids and Immunogenetics, St. Bartholomew's Hospital, London"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jowett", 
        "givenName": "N. I.", 
        "id": "sg:person.01073616051.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073616051.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Immunology, The Middlesex Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bottazzo", 
        "givenName": "G. F.", 
        "id": "sg:person.0723572726.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723572726.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St Bartholomew's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416353.6", 
          "name": [
            "Departments of Diabetes, Lipids and Immunogenetics, St. Bartholomew's Hospital, London"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Galton", 
        "givenName": "D. J.", 
        "id": "sg:person.01345655441.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345655441.60"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.78.9.5759", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002049043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(84)90126-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004358711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(81)91391-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008272243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.30.3.267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016388314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/295031a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017331230", 
          "https://doi.org/10.1038/295031a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.74.3.1245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022710425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-1809.1955.tb01348.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028738534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-2836(75)80083-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033296365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.288.6411.96", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037831712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/262795a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039927208", 
          "https://doi.org/10.1038/262795a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.31.3.275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040057453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198301133080202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040788912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00282704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041591620", 
          "https://doi.org/10.1007/bf00282704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00282704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041591620", 
          "https://doi.org/10.1007/bf00282704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00282704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041591620", 
          "https://doi.org/10.1007/bf00282704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-1809.1980.tb01572.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043025620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-1809.1981.tb00321.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048905644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs0660383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056721681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs0660383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056721681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.33.2.176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070740374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.31.11.991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070749153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081837402", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1985-04", 
    "datePublishedReg": "1985-04-01", 
    "description": "A polymorphic DNA sequence in the 5'-flanking region of the human insulin gene was studied in relation to Type 1 (insulin-dependent) diabetes. In 141 Caucasoid subjects analysed by Southern blot hybridisation techniques, two major DNA insertions were observed: a Class 1 allele or a Class 3 allele. The Class 2 allele was not observed in this group of subjects. Genotype frequencies in a control population (n = 88) were: homozygous 1/1, 42%; heterozygous 1/3, 50%; and homozygous 3/3, 8%. Corresponding genotype frequencies in 53 Type 1 diabetic patients were 79%, 21% and 0%, respectively (p less than 0.0005 from chi 2 test). This confirms prevalence data reported by Bell et al. [16]. There appeared to be no coinheritance with HLA-DR3/DR4 related antigens, nor with autoimmune features. Analysis of 17 Type 1 diabetic pedigrees including 34 diabetic and 69 non-diabetic subjects did not demonstrate genetic linkage of these DNA inserts with diabetes, using an autosomal recessive, single locus model of inheritance.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00282236", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "28"
      }
    ], 
    "name": "Type 1 (insulin-dependent) diabetes and a highly variable locus close to the insulin gene on chromosome 11", 
    "pagination": "218-222", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00282236"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "efd53ca9de68bf36639d090a8f5ecb9ddb180b461d36d034f4dd751e2cbb7679"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1050345818"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0006777"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2991052"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00282236", 
      "https://app.dimensions.ai/details/publication/pub.1050345818"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T08:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000374_0000000374/records_119717_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2FBF00282236"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00282236'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00282236'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00282236'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00282236'


 

This table displays all metadata directly associated to this object as RDF triples.

238 TRIPLES      21 PREDICATES      61 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00282236 schema:about N0ba008b6203545ed9e3a36c1dbeeaffc
2 N190a2b1257b4448bb001168def9d817d
3 N1acfea9cb0934dfc901de6fbb190cdd4
4 N32735eb2d0ae49b8a5804b6b53d3970e
5 N37bfa7c15b3d4c49a5127489354dde0a
6 N4040e2d6bceb4957a2729b147b2b8c7b
7 N41d9df803f834c5f8cd78e2a706d38a6
8 N4203e4887a5c4b5795d8a7cd8aa9bc39
9 N4b88febb8f924d90aaf591d272b73fc7
10 Na0ad5a45dd404e9e8a73a93fad1e4289
11 Nc2abaa214f4240698ef6e866df4bd5b1
12 Nec8dbf034e1a4bf780b911ad2b46744d
13 Nf56acdb80d5e4b3a8ee431b28f85e5bf
14 anzsrc-for:06
15 anzsrc-for:0604
16 schema:author Nd290974e3fb9412b818ab9c6f61ae52b
17 schema:citation sg:pub.10.1007/bf00282704
18 sg:pub.10.1038/262795a0
19 sg:pub.10.1038/295031a0
20 https://app.dimensions.ai/details/publication/pub.1081837402
21 https://doi.org/10.1016/s0022-2836(75)80083-0
22 https://doi.org/10.1016/s0140-6736(81)91391-x
23 https://doi.org/10.1016/s0140-6736(84)90126-0
24 https://doi.org/10.1042/cs0660383
25 https://doi.org/10.1056/nejm198301133080202
26 https://doi.org/10.1073/pnas.74.3.1245
27 https://doi.org/10.1073/pnas.78.9.5759
28 https://doi.org/10.1111/j.1469-1809.1955.tb01348.x
29 https://doi.org/10.1111/j.1469-1809.1980.tb01572.x
30 https://doi.org/10.1111/j.1469-1809.1981.tb00321.x
31 https://doi.org/10.1136/bmj.288.6411.96
32 https://doi.org/10.2337/diab.30.3.267
33 https://doi.org/10.2337/diab.31.3.275
34 https://doi.org/10.2337/diabetes.33.2.176
35 https://doi.org/10.2337/diacare.31.11.991
36 schema:datePublished 1985-04
37 schema:datePublishedReg 1985-04-01
38 schema:description A polymorphic DNA sequence in the 5'-flanking region of the human insulin gene was studied in relation to Type 1 (insulin-dependent) diabetes. In 141 Caucasoid subjects analysed by Southern blot hybridisation techniques, two major DNA insertions were observed: a Class 1 allele or a Class 3 allele. The Class 2 allele was not observed in this group of subjects. Genotype frequencies in a control population (n = 88) were: homozygous 1/1, 42%; heterozygous 1/3, 50%; and homozygous 3/3, 8%. Corresponding genotype frequencies in 53 Type 1 diabetic patients were 79%, 21% and 0%, respectively (p less than 0.0005 from chi 2 test). This confirms prevalence data reported by Bell et al. [16]. There appeared to be no coinheritance with HLA-DR3/DR4 related antigens, nor with autoimmune features. Analysis of 17 Type 1 diabetic pedigrees including 34 diabetic and 69 non-diabetic subjects did not demonstrate genetic linkage of these DNA inserts with diabetes, using an autosomal recessive, single locus model of inheritance.
39 schema:genre research_article
40 schema:inLanguage en
41 schema:isAccessibleForFree true
42 schema:isPartOf N785ec0fb27d84e31a9e54a3a52779251
43 Nfde29b49808146d19b794f884c022d17
44 sg:journal.1001482
45 schema:name Type 1 (insulin-dependent) diabetes and a highly variable locus close to the insulin gene on chromosome 11
46 schema:pagination 218-222
47 schema:productId N1c3b168976e0424e99c313f33afea7e5
48 N2e7d1f8b59974388af72023b9f2408fb
49 N393b993dc48f4100adced5f96b4d9383
50 Nafe3bf08eba446499cfb674f15c10eea
51 Nc988035ecda34d279fd45295449c8355
52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050345818
53 https://doi.org/10.1007/bf00282236
54 schema:sdDatePublished 2019-04-15T08:48
55 schema:sdLicense https://scigraph.springernature.com/explorer/license/
56 schema:sdPublisher N0963ecd828c6459283f43fb464bc4da4
57 schema:url https://link.springer.com/10.1007%2FBF00282236
58 sgo:license sg:explorer/license/
59 sgo:sdDataset articles
60 rdf:type schema:ScholarlyArticle
61 N0963ecd828c6459283f43fb464bc4da4 schema:name Springer Nature - SN SciGraph project
62 rdf:type schema:Organization
63 N0ba008b6203545ed9e3a36c1dbeeaffc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
64 schema:name Genetic Linkage
65 rdf:type schema:DefinedTerm
66 N13e98c2d19974a96817afdeb28565e5f schema:name Department of Immunology, The Middlesex Hospital, London, UK
67 rdf:type schema:Organization
68 N190a2b1257b4448bb001168def9d817d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Chromosomes, Human, 6-12 and X
70 rdf:type schema:DefinedTerm
71 N1acfea9cb0934dfc901de6fbb190cdd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Pedigree
73 rdf:type schema:DefinedTerm
74 N1c3b168976e0424e99c313f33afea7e5 schema:name readcube_id
75 schema:value efd53ca9de68bf36639d090a8f5ecb9ddb180b461d36d034f4dd751e2cbb7679
76 rdf:type schema:PropertyValue
77 N2541194fac594f25a8ed9ca7b1ee0bf2 rdf:first sg:person.01231725375.22
78 rdf:rest Nf05d43ca8fb24a1cb67525cdb00558b9
79 N2e7d1f8b59974388af72023b9f2408fb schema:name doi
80 schema:value 10.1007/bf00282236
81 rdf:type schema:PropertyValue
82 N32735eb2d0ae49b8a5804b6b53d3970e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Insulin
84 rdf:type schema:DefinedTerm
85 N37bfa7c15b3d4c49a5127489354dde0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name DNA Transposable Elements
87 rdf:type schema:DefinedTerm
88 N393b993dc48f4100adced5f96b4d9383 schema:name nlm_unique_id
89 schema:value 0006777
90 rdf:type schema:PropertyValue
91 N4040e2d6bceb4957a2729b147b2b8c7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Male
93 rdf:type schema:DefinedTerm
94 N41d9df803f834c5f8cd78e2a706d38a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Histocompatibility Antigens Class II
96 rdf:type schema:DefinedTerm
97 N4203e4887a5c4b5795d8a7cd8aa9bc39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Alleles
99 rdf:type schema:DefinedTerm
100 N47440147d5434465bffa707d132eab1f rdf:first sg:person.0752125673.24
101 rdf:rest Nbc13393cb7734bdbaf73208705213e81
102 N4b88febb8f924d90aaf591d272b73fc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name HLA-DR Antigens
104 rdf:type schema:DefinedTerm
105 N785ec0fb27d84e31a9e54a3a52779251 schema:issueNumber 4
106 rdf:type schema:PublicationIssue
107 N85a8372d1b8a4cd690f30797b5b2108e rdf:first sg:person.0744243751.78
108 rdf:rest N47440147d5434465bffa707d132eab1f
109 Na0ad5a45dd404e9e8a73a93fad1e4289 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Female
111 rdf:type schema:DefinedTerm
112 Nafe3bf08eba446499cfb674f15c10eea schema:name pubmed_id
113 schema:value 2991052
114 rdf:type schema:PropertyValue
115 Nb501307ce3e04730b0afd1583051ba2b rdf:first sg:person.01345655441.60
116 rdf:rest rdf:nil
117 Nbc13393cb7734bdbaf73208705213e81 rdf:first sg:person.01157633546.41
118 rdf:rest N2541194fac594f25a8ed9ca7b1ee0bf2
119 Nc2abaa214f4240698ef6e866df4bd5b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Genotype
121 rdf:type schema:DefinedTerm
122 Nc988035ecda34d279fd45295449c8355 schema:name dimensions_id
123 schema:value pub.1050345818
124 rdf:type schema:PropertyValue
125 Nd290974e3fb9412b818ab9c6f61ae52b rdf:first sg:person.01150426603.06
126 rdf:rest N85a8372d1b8a4cd690f30797b5b2108e
127 Nec8dbf034e1a4bf780b911ad2b46744d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Humans
129 rdf:type schema:DefinedTerm
130 Nf05d43ca8fb24a1cb67525cdb00558b9 rdf:first sg:person.01073616051.10
131 rdf:rest Nf8146c3aecc54670aa81ac6b50adbded
132 Nf56acdb80d5e4b3a8ee431b28f85e5bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Diabetes Mellitus, Type 1
134 rdf:type schema:DefinedTerm
135 Nf8146c3aecc54670aa81ac6b50adbded rdf:first sg:person.0723572726.20
136 rdf:rest Nb501307ce3e04730b0afd1583051ba2b
137 Nfde29b49808146d19b794f884c022d17 schema:volumeNumber 28
138 rdf:type schema:PublicationVolume
139 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
140 schema:name Biological Sciences
141 rdf:type schema:DefinedTerm
142 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
143 schema:name Genetics
144 rdf:type schema:DefinedTerm
145 sg:journal.1001482 schema:issn 0012-186X
146 1432-0428
147 schema:name Diabetologia
148 rdf:type schema:Periodical
149 sg:person.01073616051.10 schema:affiliation https://www.grid.ac/institutes/grid.416353.6
150 schema:familyName Jowett
151 schema:givenName N. I.
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073616051.10
153 rdf:type schema:Person
154 sg:person.01150426603.06 schema:affiliation https://www.grid.ac/institutes/grid.416041.6
155 schema:familyName Hitman
156 schema:givenName G. A.
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150426603.06
158 rdf:type schema:Person
159 sg:person.01157633546.41 schema:affiliation https://www.grid.ac/institutes/grid.416353.6
160 schema:familyName Drummond
161 schema:givenName V.
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157633546.41
163 rdf:type schema:Person
164 sg:person.01231725375.22 schema:affiliation https://www.grid.ac/institutes/grid.416353.6
165 schema:familyName Williams
166 schema:givenName L. G.
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231725375.22
168 rdf:type schema:Person
169 sg:person.01345655441.60 schema:affiliation https://www.grid.ac/institutes/grid.416353.6
170 schema:familyName Galton
171 schema:givenName D. J.
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345655441.60
173 rdf:type schema:Person
174 sg:person.0723572726.20 schema:affiliation N13e98c2d19974a96817afdeb28565e5f
175 schema:familyName Bottazzo
176 schema:givenName G. F.
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723572726.20
178 rdf:type schema:Person
179 sg:person.0744243751.78 schema:affiliation https://www.grid.ac/institutes/grid.416353.6
180 schema:familyName Tarn
181 schema:givenName A. C.
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744243751.78
183 rdf:type schema:Person
184 sg:person.0752125673.24 schema:affiliation https://www.grid.ac/institutes/grid.416568.8
185 schema:familyName Winter
186 schema:givenName R. M.
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752125673.24
188 rdf:type schema:Person
189 sg:pub.10.1007/bf00282704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041591620
190 https://doi.org/10.1007/bf00282704
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/262795a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039927208
193 https://doi.org/10.1038/262795a0
194 rdf:type schema:CreativeWork
195 sg:pub.10.1038/295031a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017331230
196 https://doi.org/10.1038/295031a0
197 rdf:type schema:CreativeWork
198 https://app.dimensions.ai/details/publication/pub.1081837402 schema:CreativeWork
199 https://doi.org/10.1016/s0022-2836(75)80083-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033296365
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/s0140-6736(81)91391-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008272243
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/s0140-6736(84)90126-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004358711
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1042/cs0660383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056721681
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1056/nejm198301133080202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040788912
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1073/pnas.74.3.1245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022710425
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1073/pnas.78.9.5759 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002049043
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1111/j.1469-1809.1955.tb01348.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028738534
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1111/j.1469-1809.1980.tb01572.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043025620
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1111/j.1469-1809.1981.tb00321.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048905644
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1136/bmj.288.6411.96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037831712
220 rdf:type schema:CreativeWork
221 https://doi.org/10.2337/diab.30.3.267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016388314
222 rdf:type schema:CreativeWork
223 https://doi.org/10.2337/diab.31.3.275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040057453
224 rdf:type schema:CreativeWork
225 https://doi.org/10.2337/diabetes.33.2.176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070740374
226 rdf:type schema:CreativeWork
227 https://doi.org/10.2337/diacare.31.11.991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070749153
228 rdf:type schema:CreativeWork
229 https://www.grid.ac/institutes/grid.416041.6 schema:alternateName Royal London Hospital
230 schema:name Departments of Diabetes, Lipids and Immunogenetics, St. Bartholomew's Hospital, London
231 The Medical Unit, The London Hospital, El, Whitechapel, London, UK
232 rdf:type schema:Organization
233 https://www.grid.ac/institutes/grid.416353.6 schema:alternateName St Bartholomew's Hospital
234 schema:name Departments of Diabetes, Lipids and Immunogenetics, St. Bartholomew's Hospital, London
235 rdf:type schema:Organization
236 https://www.grid.ac/institutes/grid.416568.8 schema:alternateName Northwick Park Hospital
237 schema:name Division of Inherited Metabolic Diseases, Northwick Park Hospital, Harrow
238 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...