Hemoglobin tacoma — A β-chain variant View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1966-01

AUTHORS

Ernst W. Baur, Arno G. Motulsky

ABSTRACT

A hitherto unknown inherited hemoglobin variant, Hb Tacoma, was discovered in three healthy members of a family of European extraction. Hybridization experiments with canine hemoglobin indicated a structural abnormality in the β-chain. The variant was therefore designated as Hb α2 β2Tacoma. Separation of Hb Tacoma from Hb A could only be clearly achieved by starch grain electrophoresis in TEB buffer at pH 8.6–9.0, where Hb Tacoma moved more rapidly towards the anode than Hb A; gradient column chromatography on DEAE cellulose and CM-Sephadex achieved partial separation. The proportion of abnormal hemoglobin in the heterozygote amounted to 43 per cent of the total hemoglobin. Hb Tacoma was less heat resistant and became more rapidly denatured in 8 M urea solution than Hb A, Hb C, or Hb S. On thin-layer starch gel electrophoresis in TCB buffer at pH 8.6 Hb Tacoma was associated with an electrophoretically slow, benzidine-positive component, Hb Tacoma-slow. The exact biochemical nature of this minor component could not be determined, although a polymeric product of Hb Tacoma is suspected. Heterozygosity for Hb Tacoma is associated with a raised Hb A2 level without evidence of β-thalassemia. More... »

PAGES

621-634

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00281050

DOI

http://dx.doi.org/10.1007/bf00281050

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016961220

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/5869485


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