Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1985-07

AUTHORS

D. R. Matthews, J. P. Hosker, A. S. Rudenski, B. A. Naylor, D. F. Treacher, R. C. Turner

ABSTRACT

The steady-state basal plasma glucose and insulin concentrations are determined by their interaction in a feedback loop. A computer-solved model has been used to predict the homeostatic concentrations which arise from varying degrees beta-cell deficiency and insulin resistance. Comparison of a patient's fasting values with the model's predictions allows a quantitative assessment of the contributions of insulin resistance and deficient beta-cell function to the fasting hyperglycaemia (homeostasis model assessment, HOMA). The accuracy and precision of the estimate have been determined by comparison with independent measures of insulin resistance and beta-cell function using hyperglycaemic and euglycaemic clamps and an intravenous glucose tolerance test. The estimate of insulin resistance obtained by homeostasis model assessment correlated with estimates obtained by use of the euglycaemic clamp (Rs = 0.88, p less than 0.0001), the fasting insulin concentration (Rs = 0.81, p less than 0.0001), and the hyperglycaemic clamp, (Rs = 0.69, p less than 0.01). There was no correlation with any aspect of insulin-receptor binding. The estimate of deficient beta-cell function obtained by homeostasis model assessment correlated with that derived using the hyperglycaemic clamp (Rs = 0.61, p less than 0.01) and with the estimate from the intravenous glucose tolerance test (Rs = 0.64, p less than 0.05). The low precision of the estimates from the model (coefficients of variation: 31% for insulin resistance and 32% for beta-cell deficit) limits its use, but the correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop. More... »

PAGES

412-419

Journal

TITLE

Diabetologia

ISSUE

7

VOLUME

28

Author Affiliations

Clinical Trials linked to this publication

  • The Effect Of Tai Chi Chuan On The Endothelin, Insulin, Blood Lipid, Blood Sugar, Aldosterone And Hemodynamics In The Elderly Adults
  • Omentectomy For Treatment Of Diabetes Mellitus Type 2
  • Randomized Controlled Clinical Trial Of Carbohydrate Restriction Among Men Initiating Androgen Deprivation Therapy For Prostate Cancer
  • 1/2-Mc4r Genotype And Pediatric Antipsychotic Drug- Induced Weight Gain
  • Beneficial Effect Of Dose Escalation Of Octreotide-Lar As First-Line Therapy In Patients With Resistant Acromegaly
  • Do Innovative Strategies Complement Medical Management To Reduce Cardiovascular Risk Factors Following Coronary Artery Bypass Graft Surgery?
  • Effect Of A Hypocaloric Diet With Different Glycemic Indexes On Ghrelin And Leptin Levels, Metabolic Parameters, And Reproductive Outcomes In Overweight And Obese Infertile Women: A Randomized Clinical Trial
  • Lifestyle Intervention In Preparation For Pregnancy (Lipp)
  • Sit Less, Interact, Move More (Slimm) Intervention For Sedentary Behavior In Chronic Kidney Disease (Ckd)
  • The Effect Of Acupuncture On Insulin Sensitivity Of Women With Polycystic Ovary Syndrome And Insulin Resistance: A Randomized Controlled Trial
  • Inflammatory Mediators In Obese Adolescents With Insulin Resistance Following Metformin Treatment: Controlled Randomized Clinical Trial
  • Essential Arterial Hypotension And Allostasis Registry
  • Health Benefits Of Aerobic And Resistance Training In Individuals With Type 2 Diabetes
  • Observational, Cross-Sectional, Longitudinal, Multi-Center, Diagnostic Study To Evaluate The Influence Of Acromegaly On Glucose Tolerance And To Evaluate The Changes Of Impaired Glucose Tolerance During Standard Treatment Of Acromegaly.
  • A Pilot, Non-Comparative Study To Assess The Efficacy And Safety Of The New Food Supplement Fasemets In Metabolic Syndrome
  • The Effects Of Palm Oil Consumed Under Different Macronutrient Distributions On Circulating Lipoprotein And Fatty Acid Profiles
  • Modulation Of Insulin Secretion And Insulin Sensitivity In Bangladeshi Type 2 Diabetic Subjects By An Insulin Sensitizer Pioglitazone And T2dm Association With Pparg Gene Polymorphism.
  • Related Patents

  • Crystalline Form Of 1-(Β-D-Glucopyransoyl)-4-Methyl-3-[5-(4-Fluorophenyl)-2- Thienylmethyl]Benzene Hemihydrate
  • 13c Glucose Breath Test For The Diagnosis Of Diabetic Indications And Monitoring Glycemic Control
  • 13c Glucose Breath Test For The Diagnosis Of Diabetic Indications And Monitoring Glycemic Control
  • Single Nucleotide Polymorphism Associated With Risk Of Insulin Resistance Development
  • Biomarkers For Insulin Sensitizer Drug Response
  • Method Of Haplotype-Based Genetic Analysis For Determining Risk For Developing Insulin Resistance, Coronary Artery Disease And Other Phenotypes
  • Apparatus, System And Method For Measuring Resistance Of An Inhaler
  • Dry Powder Drug Delivery System And Methods
  • Method For Insulin Resistance Improving And A Method For Prevention Or Treatment Of Diabetes
  • Dry Powder Inhaler And System For Drug Delivery
  • Method Of Treating Diabetes Type 2 By Metformin And An Ultrarapid Acting Insulin
  • Glucopyranoside Compound
  • Glucopyranoside Compound
  • Use Of Ultrarapid Acting Insulin
  • Substituted Diketopiperazine Analogs For Use As Drug Delivery Agents
  • Compounds Having An Isolated Peptide Consisting Of Structure (I)
  • Method For Improving The Pharmaceutic Properties Of Microparticles Comprising Diketopiperazine And An Active Agent
  • Dry Powder Inhaler And System For Drug Delivery
  • Method Of Controlling Glycemia By Ultrarapid Acting Insulin Without Adjusting An Insulin Dose For Meal Content
  • Determination Of A Tendency To Gain Weight
  • Method And Composition For Treating Migraines
  • Method Of Drug Formulation Based On Increasing The Affinity Of Crystalline Microparticle Surfaces For Active Agents
  • Single Nucleotide Polymorphisms Associated With Dietary Weight Loss
  • Diketopiperazine Salts For Drug Delivery And Related Methods
  • High Capacity Diketopiperazine Microparticles And Methods
  • 13c Glucose Breath Test For The Diagnosis Of Diabetic Indications And Monitoring Glycemic Control
  • Inhalation Apparatus
  • Pharmaceutical Composition Comprising A Glp-1 Agonist, An Insulin And Methionine
  • Use Of Ave0010 For The Treatment Of Diabetes Mellitus Type 2
  • Pharmaceutical Composition For Use In The Treatment Of A Neurodegenerative Disease
  • Method And Index For Diagnosing Insulin Resistance
  • Methods And Compositions For Treatment Of Metabolic Disorders
  • Process For The Preparation Of Compounds Useful As Inhibitors Of Sglt
  • Process For The Preparation Of Compounds Useful As Inhibitors Of Sglt2
  • Substituted Diketopiperazine Analogs For Use As Drug Delivery Agents
  • Use Of Ultrarapid Acting Insulin
  • 13c Glucose Breath Test For The Diagnosis Of Diabetic Indications And Monitoring Glycemic Control
  • Heat-Stable Dry Powder Pharmaceutical Compositions And Methods
  • Insulin Glargine/Lixisenatide Fixed Ratio Formulation
  • Dry Powder Inhaler And System For Drug Delivery
  • Glucopyranoside Compound
  • Interactive Apparatus And Method For Real-Time Profiling Of Inhalation Efforts
  • Pharmaceutical Composition Comprising A Glp-1-Agonist And Methionine
  • Glucopyranoside Compound
  • Telomerase Reverse Transcriptase For Protection Against Ageing
  • Method Of Haplotype-Based Genetic Analysis For Determining Risk For Developing Insulin Resistance And Coronary Artery Disease
  • Crystallisation Process For 1-(Β-D-Glucopyranosyl)-4-Methyl-3-[5-(4-Fluorophenyl)-2-Thienylmethyl] Benzene
  • Methods For Detecting Low Grade Inflammation
  • Combination Therapy Comprising Sglt Inhibitors And Dpp4 Inhibitors
  • L-Proline And Citric Acid Co-Crystals Of (2s, 3r, 4r, 5s,6r)-2-(3-((5-(4-Fluorophenyl)Thiopen-2-Yl)Methyl)4-Methylphenyl)-6-(Hydroxymethyl)Tetrahydro-2h-Pyran-3,4,5-Triol
  • Crystalline Form Of 1-(Β-D-Glucopyranosyl)-4-Methyl-3-[5-(4-Fluorophenyl)-2-Thienylmethyl]Benzene Hemihydrate
  • Dry Powder Inhaler And System For Drug Delivery
  • Potentiation Of Glucose Elimination
  • Methods For Preventing Or Treating Metabolic Syndrome
  • Potentiation Of Glucose Elimination
  • Reducing Risk Of Type 2 Diabetes (T2d)
  • Method Of Treating Fatty Liver Diseases And Conditions In Non-Lipodystrophic Subjects
  • Novel Compound, Phosphorylation Inhibitor, Insulin Resistance Improving Agent, Agent To Prevent Or To Treat Diabetes, And Screening Method
  • Use Of Ultrarapid Acting Insulin
  • Methods And Compositions For Delivering Peptides
  • Methods For Preventing Or Treating Metabolic Syndrome
  • Screening Method For An Insulin Resistance Improving Agent Or A Therapeutic Agent For Diabetes
  • Methods And Compositions For Treating Pain
  • Method Of Treating A Patient
  • Methods And Compositions For Treating Pain
  • Pharmaceutical Combination For Improving Glycemic Control As Add-On Therapy To Basal Insulin
  • Catalysis Of Diketopiperazine Synthesis
  • Apparatus And Method For Simulating Inhalation Efforts
  • Dry Powder Drug Delivery System And Methods
  • Biomarkers For Atherosclerosis
  • Use Of Ultrarapid Acting Insulin
  • Method Of Treating Diabetes Type 2 By Administering Ultrarapid Acting Insulin
  • Diagnosis And Complication Risk Assessment Of Pancreatic Diabetes Within Normal Value Ranges Of Leucocytes Using Procalcitonin
  • 13c Glucose Breath Test For The Diagnosis Of Diabetic Indications And Monitoring Glycemic Control
  • 13c Glucose Breath Test For The Diagnosis Of Diabetic Indications And Monitoring Glycemic Control
  • Diketopiperazine Microparticles With Defined Specific Surface Areas
  • Process For The Preparation Of Compounds Useful As Inhibitors Of Sglt
  • Increasing Drug Affinity For Crystalline Microparticle Surfaces
  • Catalysis Of Diketopiperazine Synthesis
  • Method To Screen For An Activator Of Adipose-Resident Nk Cells
  • Telomerase Reverse Transcriptase For Protection Against Ageing
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00280883

    DOI

    http://dx.doi.org/10.1007/bf00280883

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1027902786

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3899825


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Blood Glucose", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Computers", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diabetes Mellitus, Type 2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Erythrocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fasting", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Homeostasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Insulin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Insulin Resistance", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Islets of Langerhans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Monocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptor, Insulin", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "John Radcliffe Hospital", 
              "id": "https://www.grid.ac/institutes/grid.8348.7", 
              "name": [
                "Diabetes Research Laboratories, Radcliffe Infirmary, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matthews", 
            "givenName": "D. R.", 
            "id": "sg:person.01216556762.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216556762.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "John Radcliffe Hospital", 
              "id": "https://www.grid.ac/institutes/grid.8348.7", 
              "name": [
                "Diabetes Research Laboratories, Radcliffe Infirmary, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hosker", 
            "givenName": "J. P.", 
            "id": "sg:person.0716551025.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716551025.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "John Radcliffe Hospital", 
              "id": "https://www.grid.ac/institutes/grid.8348.7", 
              "name": [
                "Diabetes Research Laboratories, Radcliffe Infirmary, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rudenski", 
            "givenName": "A. S.", 
            "id": "sg:person.01156637623.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156637623.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "John Radcliffe Hospital", 
              "id": "https://www.grid.ac/institutes/grid.8348.7", 
              "name": [
                "Diabetes Research Laboratories, Radcliffe Infirmary, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Naylor", 
            "givenName": "B. A.", 
            "id": "sg:person.0627706757.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627706757.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "John Radcliffe Hospital", 
              "id": "https://www.grid.ac/institutes/grid.8348.7", 
              "name": [
                "Diabetes Research Laboratories, Radcliffe Infirmary, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Treacher", 
            "givenName": "D. F.", 
            "id": "sg:person.01015207513.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015207513.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "John Radcliffe Hospital", 
              "id": "https://www.grid.ac/institutes/grid.8348.7", 
              "name": [
                "Diabetes Research Laboratories, Radcliffe Infirmary, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Turner", 
            "givenName": "R. C.", 
            "id": "sg:person.014367676652.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014367676652.44"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/bf00280882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028857626", 
              "https://doi.org/10.1007/bf00280882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00280882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028857626", 
              "https://doi.org/10.1007/bf00280882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00280882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028857626", 
              "https://doi.org/10.1007/bf00280882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2265.1981.tb00196.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035301559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0026-0495(79)90146-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038472930"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00282705", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042771344", 
              "https://doi.org/10.1007/bf00282705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00282705", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042771344", 
              "https://doi.org/10.1007/bf00282705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(82)91753-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045759419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(82)91753-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045759419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/acta.0.0920148", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046492738"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/03091907809161794", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048435653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(76)91739-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049185124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(76)91739-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049185124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0026-0495(83)90024-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049399042"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00745134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051373300", 
              "https://doi.org/10.1007/bf00745134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00745134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051373300", 
              "https://doi.org/10.1007/bf00745134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00745134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051373300", 
              "https://doi.org/10.1007/bf00745134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/diab.25.12.1154", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070732879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/diab.27.7.701", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070733305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/diab.28.3.227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070733461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/diab.32.7.617", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070734391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpendo.1979.237.3.e214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079974987"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpendo.1979.236.6.e667", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1080342534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000408864", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1088682038"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1985-07", 
        "datePublishedReg": "1985-07-01", 
        "description": "The steady-state basal plasma glucose and insulin concentrations are determined by their interaction in a feedback loop. A computer-solved model has been used to predict the homeostatic concentrations which arise from varying degrees beta-cell deficiency and insulin resistance. Comparison of a patient's fasting values with the model's predictions allows a quantitative assessment of the contributions of insulin resistance and deficient beta-cell function to the fasting hyperglycaemia (homeostasis model assessment, HOMA). The accuracy and precision of the estimate have been determined by comparison with independent measures of insulin resistance and beta-cell function using hyperglycaemic and euglycaemic clamps and an intravenous glucose tolerance test. The estimate of insulin resistance obtained by homeostasis model assessment correlated with estimates obtained by use of the euglycaemic clamp (Rs = 0.88, p less than 0.0001), the fasting insulin concentration (Rs = 0.81, p less than 0.0001), and the hyperglycaemic clamp, (Rs = 0.69, p less than 0.01). There was no correlation with any aspect of insulin-receptor binding. The estimate of deficient beta-cell function obtained by homeostasis model assessment correlated with that derived using the hyperglycaemic clamp (Rs = 0.61, p less than 0.01) and with the estimate from the intravenous glucose tolerance test (Rs = 0.64, p less than 0.05). The low precision of the estimates from the model (coefficients of variation: 31% for insulin resistance and 32% for beta-cell deficit) limits its use, but the correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/bf00280883", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1001482", 
            "issn": [
              "0012-186X", 
              "1432-0428"
            ], 
            "name": "Diabetologia", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "28"
          }
        ], 
        "name": "Homeostasis model assessment: insulin resistance and \u03b2-cell function from fasting plasma glucose and insulin concentrations in man", 
        "pagination": "412-419", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "84eb6ff453d8d6070dfc7ca90f358f808aa395cba87b8bf78292c139106b3d93"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "3899825"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0006777"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/bf00280883"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1027902786"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/bf00280883", 
          "https://app.dimensions.ai/details/publication/pub.1027902786"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:59", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130826_00000002.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2FBF00280883"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00280883'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00280883'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00280883'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00280883'


     

    This table displays all metadata directly associated to this object as RDF triples.

    214 TRIPLES      21 PREDICATES      60 URIs      35 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/bf00280883 schema:about N034aba7b9b984c9eb96aeb8074d888c3
    2 N07315eefaedb4e14a852f2dfa4214af7
    3 N205862be44e24c84996284052177a678
    4 N301932513d9246a1ae1790f99deec379
    5 N4d415502f64d4122822c51d05717ac35
    6 N557c5c3566324feebcf451165bbc13af
    7 N55a86ad6de684a5eb7d8710cbd2e7a2b
    8 N5fcad6d5f1a446c8a3c461285624d049
    9 N6aa6e76f6b4e4c808448fbe24ad74dd1
    10 N8bade5bb4c7d4b18bf60e5c3a042deea
    11 Nac2238d17e524730a076a6f8521d51a0
    12 Nbc5ab6bb9a90440188ee5237510b8295
    13 Ncdc615ec02834bb8b15cd0c8e1700aea
    14 Nf6658032512d4a61bacc8519d4c5e968
    15 anzsrc-for:11
    16 anzsrc-for:1103
    17 schema:author N7730ac56f9f247e4a49690e03deea015
    18 schema:citation sg:pub.10.1007/bf00280882
    19 sg:pub.10.1007/bf00282705
    20 sg:pub.10.1007/bf00745134
    21 https://doi.org/10.1016/0026-0495(79)90146-x
    22 https://doi.org/10.1016/0026-0495(83)90024-0
    23 https://doi.org/10.1016/s0140-6736(76)91739-6
    24 https://doi.org/10.1016/s0140-6736(82)91753-6
    25 https://doi.org/10.1111/j.1365-2265.1981.tb00196.x
    26 https://doi.org/10.1152/ajpendo.1979.236.6.e667
    27 https://doi.org/10.1152/ajpendo.1979.237.3.e214
    28 https://doi.org/10.1159/000408864
    29 https://doi.org/10.1530/acta.0.0920148
    30 https://doi.org/10.2337/diab.25.12.1154
    31 https://doi.org/10.2337/diab.27.7.701
    32 https://doi.org/10.2337/diab.28.3.227
    33 https://doi.org/10.2337/diab.32.7.617
    34 https://doi.org/10.3109/03091907809161794
    35 schema:datePublished 1985-07
    36 schema:datePublishedReg 1985-07-01
    37 schema:description The steady-state basal plasma glucose and insulin concentrations are determined by their interaction in a feedback loop. A computer-solved model has been used to predict the homeostatic concentrations which arise from varying degrees beta-cell deficiency and insulin resistance. Comparison of a patient's fasting values with the model's predictions allows a quantitative assessment of the contributions of insulin resistance and deficient beta-cell function to the fasting hyperglycaemia (homeostasis model assessment, HOMA). The accuracy and precision of the estimate have been determined by comparison with independent measures of insulin resistance and beta-cell function using hyperglycaemic and euglycaemic clamps and an intravenous glucose tolerance test. The estimate of insulin resistance obtained by homeostasis model assessment correlated with estimates obtained by use of the euglycaemic clamp (Rs = 0.88, p less than 0.0001), the fasting insulin concentration (Rs = 0.81, p less than 0.0001), and the hyperglycaemic clamp, (Rs = 0.69, p less than 0.01). There was no correlation with any aspect of insulin-receptor binding. The estimate of deficient beta-cell function obtained by homeostasis model assessment correlated with that derived using the hyperglycaemic clamp (Rs = 0.61, p less than 0.01) and with the estimate from the intravenous glucose tolerance test (Rs = 0.64, p less than 0.05). The low precision of the estimates from the model (coefficients of variation: 31% for insulin resistance and 32% for beta-cell deficit) limits its use, but the correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop.
    38 schema:genre research_article
    39 schema:inLanguage en
    40 schema:isAccessibleForFree true
    41 schema:isPartOf N4a47c5c79ad74d35af672a6054cfb8d3
    42 Nc9f1483004fe4e769ea26a8a58973b84
    43 sg:journal.1001482
    44 schema:name Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man
    45 schema:pagination 412-419
    46 schema:productId N11121e612552491684b9855e90deb0d9
    47 N1fdd1b79b94d4fd08a6d5776832ae4d6
    48 N9bd58518eaac46f7a3c0e2036fceda73
    49 N9e73d61b00bd4507a6c59161187240e2
    50 Nb8af57968e844e7ab735f7daf1ee4ab6
    51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027902786
    52 https://doi.org/10.1007/bf00280883
    53 schema:sdDatePublished 2019-04-11T13:59
    54 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    55 schema:sdPublisher N42f4fcdf3b1440999edce7d543a84bcd
    56 schema:url https://link.springer.com/10.1007%2FBF00280883
    57 sgo:license sg:explorer/license/
    58 sgo:sdDataset articles
    59 rdf:type schema:ScholarlyArticle
    60 N034aba7b9b984c9eb96aeb8074d888c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    61 schema:name Homeostasis
    62 rdf:type schema:DefinedTerm
    63 N07315eefaedb4e14a852f2dfa4214af7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    64 schema:name Computers
    65 rdf:type schema:DefinedTerm
    66 N11121e612552491684b9855e90deb0d9 schema:name nlm_unique_id
    67 schema:value 0006777
    68 rdf:type schema:PropertyValue
    69 N1c0d5a3a167e48fba828f08a2bfee5dc rdf:first sg:person.01015207513.12
    70 rdf:rest Nb45e3341fe874c50888be5e2738f8768
    71 N1fdd1b79b94d4fd08a6d5776832ae4d6 schema:name pubmed_id
    72 schema:value 3899825
    73 rdf:type schema:PropertyValue
    74 N205862be44e24c84996284052177a678 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    75 schema:name Blood Glucose
    76 rdf:type schema:DefinedTerm
    77 N301932513d9246a1ae1790f99deec379 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    78 schema:name Insulin Resistance
    79 rdf:type schema:DefinedTerm
    80 N317df671e809477ba2697788cdf8c6c7 rdf:first sg:person.0716551025.95
    81 rdf:rest Nb57aa49dbf4c42458d82bd9e665ebc65
    82 N42f4fcdf3b1440999edce7d543a84bcd schema:name Springer Nature - SN SciGraph project
    83 rdf:type schema:Organization
    84 N4a47c5c79ad74d35af672a6054cfb8d3 schema:volumeNumber 28
    85 rdf:type schema:PublicationVolume
    86 N4d415502f64d4122822c51d05717ac35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    87 schema:name Diabetes Mellitus, Type 2
    88 rdf:type schema:DefinedTerm
    89 N557c5c3566324feebcf451165bbc13af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    90 schema:name Islets of Langerhans
    91 rdf:type schema:DefinedTerm
    92 N55a86ad6de684a5eb7d8710cbd2e7a2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    93 schema:name Humans
    94 rdf:type schema:DefinedTerm
    95 N5fcad6d5f1a446c8a3c461285624d049 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    96 schema:name Erythrocytes
    97 rdf:type schema:DefinedTerm
    98 N5fe83fb25ffb4e38bc2c45984b4cec50 rdf:first sg:person.0627706757.89
    99 rdf:rest N1c0d5a3a167e48fba828f08a2bfee5dc
    100 N6aa6e76f6b4e4c808448fbe24ad74dd1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    101 schema:name Monocytes
    102 rdf:type schema:DefinedTerm
    103 N7730ac56f9f247e4a49690e03deea015 rdf:first sg:person.01216556762.76
    104 rdf:rest N317df671e809477ba2697788cdf8c6c7
    105 N8bade5bb4c7d4b18bf60e5c3a042deea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Middle Aged
    107 rdf:type schema:DefinedTerm
    108 N9bd58518eaac46f7a3c0e2036fceda73 schema:name doi
    109 schema:value 10.1007/bf00280883
    110 rdf:type schema:PropertyValue
    111 N9e73d61b00bd4507a6c59161187240e2 schema:name dimensions_id
    112 schema:value pub.1027902786
    113 rdf:type schema:PropertyValue
    114 Nac2238d17e524730a076a6f8521d51a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Insulin
    116 rdf:type schema:DefinedTerm
    117 Nb45e3341fe874c50888be5e2738f8768 rdf:first sg:person.014367676652.44
    118 rdf:rest rdf:nil
    119 Nb57aa49dbf4c42458d82bd9e665ebc65 rdf:first sg:person.01156637623.46
    120 rdf:rest N5fe83fb25ffb4e38bc2c45984b4cec50
    121 Nb8af57968e844e7ab735f7daf1ee4ab6 schema:name readcube_id
    122 schema:value 84eb6ff453d8d6070dfc7ca90f358f808aa395cba87b8bf78292c139106b3d93
    123 rdf:type schema:PropertyValue
    124 Nbc5ab6bb9a90440188ee5237510b8295 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Fasting
    126 rdf:type schema:DefinedTerm
    127 Nc9f1483004fe4e769ea26a8a58973b84 schema:issueNumber 7
    128 rdf:type schema:PublicationIssue
    129 Ncdc615ec02834bb8b15cd0c8e1700aea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Adult
    131 rdf:type schema:DefinedTerm
    132 Nf6658032512d4a61bacc8519d4c5e968 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Receptor, Insulin
    134 rdf:type schema:DefinedTerm
    135 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    136 schema:name Medical and Health Sciences
    137 rdf:type schema:DefinedTerm
    138 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    139 schema:name Clinical Sciences
    140 rdf:type schema:DefinedTerm
    141 sg:journal.1001482 schema:issn 0012-186X
    142 1432-0428
    143 schema:name Diabetologia
    144 rdf:type schema:Periodical
    145 sg:person.01015207513.12 schema:affiliation https://www.grid.ac/institutes/grid.8348.7
    146 schema:familyName Treacher
    147 schema:givenName D. F.
    148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015207513.12
    149 rdf:type schema:Person
    150 sg:person.01156637623.46 schema:affiliation https://www.grid.ac/institutes/grid.8348.7
    151 schema:familyName Rudenski
    152 schema:givenName A. S.
    153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156637623.46
    154 rdf:type schema:Person
    155 sg:person.01216556762.76 schema:affiliation https://www.grid.ac/institutes/grid.8348.7
    156 schema:familyName Matthews
    157 schema:givenName D. R.
    158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216556762.76
    159 rdf:type schema:Person
    160 sg:person.014367676652.44 schema:affiliation https://www.grid.ac/institutes/grid.8348.7
    161 schema:familyName Turner
    162 schema:givenName R. C.
    163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014367676652.44
    164 rdf:type schema:Person
    165 sg:person.0627706757.89 schema:affiliation https://www.grid.ac/institutes/grid.8348.7
    166 schema:familyName Naylor
    167 schema:givenName B. A.
    168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627706757.89
    169 rdf:type schema:Person
    170 sg:person.0716551025.95 schema:affiliation https://www.grid.ac/institutes/grid.8348.7
    171 schema:familyName Hosker
    172 schema:givenName J. P.
    173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716551025.95
    174 rdf:type schema:Person
    175 sg:pub.10.1007/bf00280882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028857626
    176 https://doi.org/10.1007/bf00280882
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1007/bf00282705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042771344
    179 https://doi.org/10.1007/bf00282705
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1007/bf00745134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051373300
    182 https://doi.org/10.1007/bf00745134
    183 rdf:type schema:CreativeWork
    184 https://doi.org/10.1016/0026-0495(79)90146-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038472930
    185 rdf:type schema:CreativeWork
    186 https://doi.org/10.1016/0026-0495(83)90024-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049399042
    187 rdf:type schema:CreativeWork
    188 https://doi.org/10.1016/s0140-6736(76)91739-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049185124
    189 rdf:type schema:CreativeWork
    190 https://doi.org/10.1016/s0140-6736(82)91753-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045759419
    191 rdf:type schema:CreativeWork
    192 https://doi.org/10.1111/j.1365-2265.1981.tb00196.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035301559
    193 rdf:type schema:CreativeWork
    194 https://doi.org/10.1152/ajpendo.1979.236.6.e667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080342534
    195 rdf:type schema:CreativeWork
    196 https://doi.org/10.1152/ajpendo.1979.237.3.e214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079974987
    197 rdf:type schema:CreativeWork
    198 https://doi.org/10.1159/000408864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1088682038
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1530/acta.0.0920148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046492738
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.2337/diab.25.12.1154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070732879
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.2337/diab.27.7.701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070733305
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.2337/diab.28.3.227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070733461
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.2337/diab.32.7.617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070734391
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.3109/03091907809161794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048435653
    211 rdf:type schema:CreativeWork
    212 https://www.grid.ac/institutes/grid.8348.7 schema:alternateName John Radcliffe Hospital
    213 schema:name Diabetes Research Laboratories, Radcliffe Infirmary, Oxford, UK
    214 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...