Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1985-07

AUTHORS

D. R. Matthews, J. P. Hosker, A. S. Rudenski, B. A. Naylor, D. F. Treacher, R. C. Turner

ABSTRACT

The steady-state basal plasma glucose and insulin concentrations are determined by their interaction in a feedback loop. A computer-solved model has been used to predict the homeostatic concentrations which arise from varying degrees beta-cell deficiency and insulin resistance. Comparison of a patient's fasting values with the model's predictions allows a quantitative assessment of the contributions of insulin resistance and deficient beta-cell function to the fasting hyperglycaemia (homeostasis model assessment, HOMA). The accuracy and precision of the estimate have been determined by comparison with independent measures of insulin resistance and beta-cell function using hyperglycaemic and euglycaemic clamps and an intravenous glucose tolerance test. The estimate of insulin resistance obtained by homeostasis model assessment correlated with estimates obtained by use of the euglycaemic clamp (Rs = 0.88, p less than 0.0001), the fasting insulin concentration (Rs = 0.81, p less than 0.0001), and the hyperglycaemic clamp, (Rs = 0.69, p less than 0.01). There was no correlation with any aspect of insulin-receptor binding. The estimate of deficient beta-cell function obtained by homeostasis model assessment correlated with that derived using the hyperglycaemic clamp (Rs = 0.61, p less than 0.01) and with the estimate from the intravenous glucose tolerance test (Rs = 0.64, p less than 0.05). The low precision of the estimates from the model (coefficients of variation: 31% for insulin resistance and 32% for beta-cell deficit) limits its use, but the correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop. More... »

PAGES

412-419

References to SciGraph publications

Journal

TITLE

Diabetologia

ISSUE

7

VOLUME

28

Author Affiliations

Clinical Trials linked to this publication

  • The Effect Of Tai Chi Chuan On The Endothelin, Insulin, Blood Lipid, Blood Sugar, Aldosterone And Hemodynamics In The Elderly Adults
  • Randomized Controlled Clinical Trial Of Carbohydrate Restriction Among Men Initiating Androgen Deprivation Therapy For Prostate Cancer
  • 1/2-Mc4r Genotype And Pediatric Antipsychotic Drug- Induced Weight Gain
  • Omentectomy For Treatment Of Diabetes Mellitus Type 2
  • Beneficial Effect Of Dose Escalation Of Octreotide-Lar As First-Line Therapy In Patients With Resistant Acromegaly
  • Do Innovative Strategies Complement Medical Management To Reduce Cardiovascular Risk Factors Following Coronary Artery Bypass Graft Surgery?
  • Effect Of A Hypocaloric Diet With Different Glycemic Indexes On Ghrelin And Leptin Levels, Metabolic Parameters, And Reproductive Outcomes In Overweight And Obese Infertile Women: A Randomized Clinical Trial
  • Sit Less, Interact, Move More (Slimm) Intervention For Sedentary Behavior In Chronic Kidney Disease (Ckd)
  • Lifestyle Intervention In Preparation For Pregnancy (Lipp)
  • The Effect Of Acupuncture On Insulin Sensitivity Of Women With Polycystic Ovary Syndrome And Insulin Resistance: A Randomized Controlled Trial
  • Inflammatory Mediators In Obese Adolescents With Insulin Resistance Following Metformin Treatment: Controlled Randomized Clinical Trial
  • Essential Arterial Hypotension And Allostasis Registry
  • Health Benefits Of Aerobic And Resistance Training In Individuals With Type 2 Diabetes
  • A Pilot, Non-Comparative Study To Assess The Efficacy And Safety Of The New Food Supplement Fasemets In Metabolic Syndrome
  • The Effects Of Palm Oil Consumed Under Different Macronutrient Distributions On Circulating Lipoprotein And Fatty Acid Profiles
  • Modulation Of Insulin Secretion And Insulin Sensitivity In Bangladeshi Type 2 Diabetic Subjects By An Insulin Sensitizer Pioglitazone And T2dm Association With Pparg Gene Polymorphism.
  • Observational, Cross-Sectional, Longitudinal, Multi-Center, Diagnostic Study To Evaluate The Influence Of Acromegaly On Glucose Tolerance And To Evaluate The Changes Of Impaired Glucose Tolerance During Standard Treatment Of Acromegaly.
  • Related Patents

  • Biomarkers For Insulin Sensitizer Drug Response
  • Single Nucleotide Polymorphism Associated With Risk Of Insulin Resistance Development
  • Method Of Haplotype-Based Genetic Analysis For Determining Risk For Developing Insulin Resistance, Coronary Artery Disease And Other Phenotypes
  • Crystalline Form Of 1-(Β-D-Glucopyransoyl)-4-Methyl-3-[5-(4-Fluorophenyl)-2- Thienylmethyl]Benzene Hemihydrate
  • Method For Insulin Resistance Improving And A Method For Prevention Or Treatment Of Diabetes
  • Apparatus, System And Method For Measuring Resistance Of An Inhaler
  • 13c Glucose Breath Test For The Diagnosis Of Diabetic Indications And Monitoring Glycemic Control
  • 13c Glucose Breath Test For The Diagnosis Of Diabetic Indications And Monitoring Glycemic Control
  • Dry Powder Drug Delivery System And Methods
  • Dry Powder Inhaler And System For Drug Delivery
  • Glucopyranoside Compound
  • Substituted Diketopiperazine Analogs For Use As Drug Delivery Agents
  • Method For Improving The Pharmaceutic Properties Of Microparticles Comprising Diketopiperazine And An Active Agent
  • Dry Powder Inhaler And System For Drug Delivery
  • Method Of Treating Diabetes Type 2 By Metformin And An Ultrarapid Acting Insulin
  • Method Of Controlling Glycemia By Ultrarapid Acting Insulin Without Adjusting An Insulin Dose For Meal Content
  • Compounds Having An Isolated Peptide Consisting Of Structure (I)
  • Use Of Ultrarapid Acting Insulin
  • Glucopyranoside Compound
  • Inhalation Apparatus
  • Pharmaceutical Composition Comprising A Glp-1 Agonist, An Insulin And Methionine
  • Use Of Ave0010 For The Treatment Of Diabetes Mellitus Type 2
  • Pharmaceutical Composition For Use In The Treatment Of A Neurodegenerative Disease
  • Single Nucleotide Polymorphisms Associated With Dietary Weight Loss
  • Diketopiperazine Salts For Drug Delivery And Related Methods
  • High Capacity Diketopiperazine Microparticles And Methods
  • Determination Of A Tendency To Gain Weight
  • 13c Glucose Breath Test For The Diagnosis Of Diabetic Indications And Monitoring Glycemic Control
  • Method And Index For Diagnosing Insulin Resistance
  • Method Of Drug Formulation Based On Increasing The Affinity Of Crystalline Microparticle Surfaces For Active Agents
  • Method And Composition For Treating Migraines
  • Methods And Compositions For Treatment Of Metabolic Disorders
  • Use Of Ultrarapid Acting Insulin
  • 13c Glucose Breath Test For The Diagnosis Of Diabetic Indications And Monitoring Glycemic Control
  • Process For The Preparation Of Compounds Useful As Inhibitors Of Sglt2
  • Process For The Preparation Of Compounds Useful As Inhibitors Of Sglt
  • Substituted Diketopiperazine Analogs For Use As Drug Delivery Agents
  • Heat-Stable Dry Powder Pharmaceutical Compositions And Methods
  • Insulin Glargine/Lixisenatide Fixed Ratio Formulation
  • Dry Powder Inhaler And System For Drug Delivery
  • Glucopyranoside Compound
  • Interactive Apparatus And Method For Real-Time Profiling Of Inhalation Efforts
  • Pharmaceutical Composition Comprising A Glp-1-Agonist And Methionine
  • Glucopyranoside Compound
  • Telomerase Reverse Transcriptase For Protection Against Ageing
  • Method Of Haplotype-Based Genetic Analysis For Determining Risk For Developing Insulin Resistance And Coronary Artery Disease
  • Crystallisation Process For 1-(Β-D-Glucopyranosyl)-4-Methyl-3-[5-(4-Fluorophenyl)-2-Thienylmethyl] Benzene
  • Methods For Detecting Low Grade Inflammation
  • Combination Therapy Comprising Sglt Inhibitors And Dpp4 Inhibitors
  • L-Proline And Citric Acid Co-Crystals Of (2s, 3r, 4r, 5s,6r)-2-(3-((5-(4-Fluorophenyl)Thiopen-2-Yl)Methyl)4-Methylphenyl)-6-(Hydroxymethyl)Tetrahydro-2h-Pyran-3,4,5-Triol
  • Crystalline Form Of 1-(Β-D-Glucopyranosyl)-4-Methyl-3-[5-(4-Fluorophenyl)-2-Thienylmethyl]Benzene Hemihydrate
  • Dry Powder Inhaler And System For Drug Delivery
  • Potentiation Of Glucose Elimination
  • Methods For Preventing Or Treating Metabolic Syndrome
  • Potentiation Of Glucose Elimination
  • Reducing Risk Of Type 2 Diabetes (T2d)
  • Method Of Treating Fatty Liver Diseases And Conditions In Non-Lipodystrophic Subjects
  • Novel Compound, Phosphorylation Inhibitor, Insulin Resistance Improving Agent, Agent To Prevent Or To Treat Diabetes, And Screening Method
  • Use Of Ultrarapid Acting Insulin
  • Methods And Compositions For Delivering Peptides
  • Methods For Preventing Or Treating Metabolic Syndrome
  • Screening Method For An Insulin Resistance Improving Agent Or A Therapeutic Agent For Diabetes
  • Methods And Compositions For Treating Pain
  • Method Of Treating A Patient
  • Methods And Compositions For Treating Pain
  • Pharmaceutical Combination For Improving Glycemic Control As Add-On Therapy To Basal Insulin
  • Catalysis Of Diketopiperazine Synthesis
  • Apparatus And Method For Simulating Inhalation Efforts
  • Dry Powder Drug Delivery System And Methods
  • Diagnosis And Complication Risk Assessment Of Pancreatic Diabetes Within Normal Value Ranges Of Leucocytes Using Procalcitonin
  • Method Of Treating Diabetes Type 2 By Administering Ultrarapid Acting Insulin
  • 13c Glucose Breath Test For The Diagnosis Of Diabetic Indications And Monitoring Glycemic Control
  • 13c Glucose Breath Test For The Diagnosis Of Diabetic Indications And Monitoring Glycemic Control
  • Use Of Ultrarapid Acting Insulin
  • Increasing Drug Affinity For Crystalline Microparticle Surfaces
  • Process For The Preparation Of Compounds Useful As Inhibitors Of Sglt
  • Biomarkers For Atherosclerosis
  • Method To Screen For An Activator Of Adipose-Resident Nk Cells
  • Catalysis Of Diketopiperazine Synthesis
  • Diketopiperazine Microparticles With Defined Specific Surface Areas
  • Telomerase Reverse Transcriptase For Protection Against Ageing
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00280883

    DOI

    http://dx.doi.org/10.1007/bf00280883

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1027902786

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3899825


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Blood Glucose", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Computers", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diabetes Mellitus, Type 2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Erythrocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fasting", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Homeostasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Insulin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Insulin Resistance", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Islets of Langerhans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Monocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptor, Insulin", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "John Radcliffe Hospital", 
              "id": "https://www.grid.ac/institutes/grid.8348.7", 
              "name": [
                "Diabetes Research Laboratories, Radcliffe Infirmary, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matthews", 
            "givenName": "D. R.", 
            "id": "sg:person.01216556762.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216556762.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "John Radcliffe Hospital", 
              "id": "https://www.grid.ac/institutes/grid.8348.7", 
              "name": [
                "Diabetes Research Laboratories, Radcliffe Infirmary, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hosker", 
            "givenName": "J. P.", 
            "id": "sg:person.0716551025.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716551025.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "John Radcliffe Hospital", 
              "id": "https://www.grid.ac/institutes/grid.8348.7", 
              "name": [
                "Diabetes Research Laboratories, Radcliffe Infirmary, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rudenski", 
            "givenName": "A. S.", 
            "id": "sg:person.01156637623.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156637623.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "John Radcliffe Hospital", 
              "id": "https://www.grid.ac/institutes/grid.8348.7", 
              "name": [
                "Diabetes Research Laboratories, Radcliffe Infirmary, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Naylor", 
            "givenName": "B. A.", 
            "id": "sg:person.0627706757.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627706757.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "John Radcliffe Hospital", 
              "id": "https://www.grid.ac/institutes/grid.8348.7", 
              "name": [
                "Diabetes Research Laboratories, Radcliffe Infirmary, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Treacher", 
            "givenName": "D. F.", 
            "id": "sg:person.01015207513.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015207513.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "John Radcliffe Hospital", 
              "id": "https://www.grid.ac/institutes/grid.8348.7", 
              "name": [
                "Diabetes Research Laboratories, Radcliffe Infirmary, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Turner", 
            "givenName": "R. C.", 
            "id": "sg:person.014367676652.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014367676652.44"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/bf00280882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028857626", 
              "https://doi.org/10.1007/bf00280882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00280882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028857626", 
              "https://doi.org/10.1007/bf00280882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00280882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028857626", 
              "https://doi.org/10.1007/bf00280882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2265.1981.tb00196.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035301559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0026-0495(79)90146-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038472930"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00282705", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042771344", 
              "https://doi.org/10.1007/bf00282705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00282705", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042771344", 
              "https://doi.org/10.1007/bf00282705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(82)91753-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045759419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(82)91753-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045759419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/acta.0.0920148", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046492738"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/03091907809161794", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048435653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(76)91739-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049185124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(76)91739-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049185124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0026-0495(83)90024-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049399042"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00745134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051373300", 
              "https://doi.org/10.1007/bf00745134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00745134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051373300", 
              "https://doi.org/10.1007/bf00745134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00745134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051373300", 
              "https://doi.org/10.1007/bf00745134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/diab.25.12.1154", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070732879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/diab.27.7.701", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070733305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/diab.28.3.227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070733461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/diab.32.7.617", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070734391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpendo.1979.237.3.e214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079974987"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpendo.1979.236.6.e667", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1080342534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000408864", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1088682038"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1985-07", 
        "datePublishedReg": "1985-07-01", 
        "description": "The steady-state basal plasma glucose and insulin concentrations are determined by their interaction in a feedback loop. A computer-solved model has been used to predict the homeostatic concentrations which arise from varying degrees beta-cell deficiency and insulin resistance. Comparison of a patient's fasting values with the model's predictions allows a quantitative assessment of the contributions of insulin resistance and deficient beta-cell function to the fasting hyperglycaemia (homeostasis model assessment, HOMA). The accuracy and precision of the estimate have been determined by comparison with independent measures of insulin resistance and beta-cell function using hyperglycaemic and euglycaemic clamps and an intravenous glucose tolerance test. The estimate of insulin resistance obtained by homeostasis model assessment correlated with estimates obtained by use of the euglycaemic clamp (Rs = 0.88, p less than 0.0001), the fasting insulin concentration (Rs = 0.81, p less than 0.0001), and the hyperglycaemic clamp, (Rs = 0.69, p less than 0.01). There was no correlation with any aspect of insulin-receptor binding. The estimate of deficient beta-cell function obtained by homeostasis model assessment correlated with that derived using the hyperglycaemic clamp (Rs = 0.61, p less than 0.01) and with the estimate from the intravenous glucose tolerance test (Rs = 0.64, p less than 0.05). The low precision of the estimates from the model (coefficients of variation: 31% for insulin resistance and 32% for beta-cell deficit) limits its use, but the correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/bf00280883", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1001482", 
            "issn": [
              "0012-186X", 
              "1432-0428"
            ], 
            "name": "Diabetologia", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "28"
          }
        ], 
        "name": "Homeostasis model assessment: insulin resistance and \u03b2-cell function from fasting plasma glucose and insulin concentrations in man", 
        "pagination": "412-419", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "84eb6ff453d8d6070dfc7ca90f358f808aa395cba87b8bf78292c139106b3d93"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "3899825"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0006777"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/bf00280883"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1027902786"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/bf00280883", 
          "https://app.dimensions.ai/details/publication/pub.1027902786"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:59", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130826_00000002.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2FBF00280883"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00280883'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00280883'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00280883'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00280883'


     

    This table displays all metadata directly associated to this object as RDF triples.

    214 TRIPLES      21 PREDICATES      60 URIs      35 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/bf00280883 schema:about N10b7fc483a0547818a59e57fb8636fc9
    2 N2033583e016d47afb9bae2c0d45aaba0
    3 N2e0be18d8a3a4d0d98e13408ee06494f
    4 N2f5d7c18b9784696b6eb75fb30aceb7b
    5 N3bdbe40087b6493dbe1110ea847939bc
    6 N493389eb177142d0a225eeeeb984154a
    7 N5838fee63bf34dc7b5b01f1641b32b96
    8 N8b53d28654a64e14a4ab3088e8a95f88
    9 N9c5ae64d31344576b53581ab8301949e
    10 Na67a5c3fa4f147d88aa9ed028a72e964
    11 Nce39a1a7e71b40fb866dad87fe2b760a
    12 Nf2d5aa1f55b44f53b56e679a9116c784
    13 Nfed1500fa19147b7b1b900e7194b11b5
    14 Nff0e3d137efb40fca71360b8a67be01e
    15 anzsrc-for:11
    16 anzsrc-for:1103
    17 schema:author Nc1f31e898a914843b61a785db6666da9
    18 schema:citation sg:pub.10.1007/bf00280882
    19 sg:pub.10.1007/bf00282705
    20 sg:pub.10.1007/bf00745134
    21 https://doi.org/10.1016/0026-0495(79)90146-x
    22 https://doi.org/10.1016/0026-0495(83)90024-0
    23 https://doi.org/10.1016/s0140-6736(76)91739-6
    24 https://doi.org/10.1016/s0140-6736(82)91753-6
    25 https://doi.org/10.1111/j.1365-2265.1981.tb00196.x
    26 https://doi.org/10.1152/ajpendo.1979.236.6.e667
    27 https://doi.org/10.1152/ajpendo.1979.237.3.e214
    28 https://doi.org/10.1159/000408864
    29 https://doi.org/10.1530/acta.0.0920148
    30 https://doi.org/10.2337/diab.25.12.1154
    31 https://doi.org/10.2337/diab.27.7.701
    32 https://doi.org/10.2337/diab.28.3.227
    33 https://doi.org/10.2337/diab.32.7.617
    34 https://doi.org/10.3109/03091907809161794
    35 schema:datePublished 1985-07
    36 schema:datePublishedReg 1985-07-01
    37 schema:description The steady-state basal plasma glucose and insulin concentrations are determined by their interaction in a feedback loop. A computer-solved model has been used to predict the homeostatic concentrations which arise from varying degrees beta-cell deficiency and insulin resistance. Comparison of a patient's fasting values with the model's predictions allows a quantitative assessment of the contributions of insulin resistance and deficient beta-cell function to the fasting hyperglycaemia (homeostasis model assessment, HOMA). The accuracy and precision of the estimate have been determined by comparison with independent measures of insulin resistance and beta-cell function using hyperglycaemic and euglycaemic clamps and an intravenous glucose tolerance test. The estimate of insulin resistance obtained by homeostasis model assessment correlated with estimates obtained by use of the euglycaemic clamp (Rs = 0.88, p less than 0.0001), the fasting insulin concentration (Rs = 0.81, p less than 0.0001), and the hyperglycaemic clamp, (Rs = 0.69, p less than 0.01). There was no correlation with any aspect of insulin-receptor binding. The estimate of deficient beta-cell function obtained by homeostasis model assessment correlated with that derived using the hyperglycaemic clamp (Rs = 0.61, p less than 0.01) and with the estimate from the intravenous glucose tolerance test (Rs = 0.64, p less than 0.05). The low precision of the estimates from the model (coefficients of variation: 31% for insulin resistance and 32% for beta-cell deficit) limits its use, but the correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop.
    38 schema:genre research_article
    39 schema:inLanguage en
    40 schema:isAccessibleForFree true
    41 schema:isPartOf N2cf56b844180439990628a422ed2fe9c
    42 N34498ddf3bb84b139098cfd9161740fd
    43 sg:journal.1001482
    44 schema:name Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man
    45 schema:pagination 412-419
    46 schema:productId N05c5f8d35cf64df4b8a495104f580d75
    47 N180ccd22be704de2955859bbdf97440f
    48 N842461fb8aff4155babace1192c0ea3a
    49 Nb29298e985204dbcaef5880352325ccf
    50 Nd732503b35284d6ca475f60b14f348df
    51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027902786
    52 https://doi.org/10.1007/bf00280883
    53 schema:sdDatePublished 2019-04-11T13:59
    54 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    55 schema:sdPublisher N3391e20319a3482497cb5e050db6bc11
    56 schema:url https://link.springer.com/10.1007%2FBF00280883
    57 sgo:license sg:explorer/license/
    58 sgo:sdDataset articles
    59 rdf:type schema:ScholarlyArticle
    60 N05c5f8d35cf64df4b8a495104f580d75 schema:name doi
    61 schema:value 10.1007/bf00280883
    62 rdf:type schema:PropertyValue
    63 N0a7eaf3e6dc34d0abedd560cb066e13d rdf:first sg:person.01015207513.12
    64 rdf:rest Na7803d1c49044f0c92bed9bb40313444
    65 N10b7fc483a0547818a59e57fb8636fc9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    66 schema:name Monocytes
    67 rdf:type schema:DefinedTerm
    68 N180ccd22be704de2955859bbdf97440f schema:name readcube_id
    69 schema:value 84eb6ff453d8d6070dfc7ca90f358f808aa395cba87b8bf78292c139106b3d93
    70 rdf:type schema:PropertyValue
    71 N2033583e016d47afb9bae2c0d45aaba0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    72 schema:name Receptor, Insulin
    73 rdf:type schema:DefinedTerm
    74 N2cf56b844180439990628a422ed2fe9c schema:volumeNumber 28
    75 rdf:type schema:PublicationVolume
    76 N2e0be18d8a3a4d0d98e13408ee06494f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    77 schema:name Diabetes Mellitus, Type 2
    78 rdf:type schema:DefinedTerm
    79 N2f5d7c18b9784696b6eb75fb30aceb7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    80 schema:name Blood Glucose
    81 rdf:type schema:DefinedTerm
    82 N3391e20319a3482497cb5e050db6bc11 schema:name Springer Nature - SN SciGraph project
    83 rdf:type schema:Organization
    84 N34498ddf3bb84b139098cfd9161740fd schema:issueNumber 7
    85 rdf:type schema:PublicationIssue
    86 N3bdbe40087b6493dbe1110ea847939bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    87 schema:name Humans
    88 rdf:type schema:DefinedTerm
    89 N437fcf448b304f259361d133cc93c245 rdf:first sg:person.01156637623.46
    90 rdf:rest N9fbb3152fad64cebba2cb05c108b87ee
    91 N493389eb177142d0a225eeeeb984154a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    92 schema:name Erythrocytes
    93 rdf:type schema:DefinedTerm
    94 N5838fee63bf34dc7b5b01f1641b32b96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    95 schema:name Computers
    96 rdf:type schema:DefinedTerm
    97 N6069251b3a8c4f7982d2f0c06b396e98 rdf:first sg:person.0716551025.95
    98 rdf:rest N437fcf448b304f259361d133cc93c245
    99 N842461fb8aff4155babace1192c0ea3a schema:name dimensions_id
    100 schema:value pub.1027902786
    101 rdf:type schema:PropertyValue
    102 N8b53d28654a64e14a4ab3088e8a95f88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Insulin
    104 rdf:type schema:DefinedTerm
    105 N9c5ae64d31344576b53581ab8301949e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Islets of Langerhans
    107 rdf:type schema:DefinedTerm
    108 N9fbb3152fad64cebba2cb05c108b87ee rdf:first sg:person.0627706757.89
    109 rdf:rest N0a7eaf3e6dc34d0abedd560cb066e13d
    110 Na67a5c3fa4f147d88aa9ed028a72e964 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Homeostasis
    112 rdf:type schema:DefinedTerm
    113 Na7803d1c49044f0c92bed9bb40313444 rdf:first sg:person.014367676652.44
    114 rdf:rest rdf:nil
    115 Nb29298e985204dbcaef5880352325ccf schema:name nlm_unique_id
    116 schema:value 0006777
    117 rdf:type schema:PropertyValue
    118 Nc1f31e898a914843b61a785db6666da9 rdf:first sg:person.01216556762.76
    119 rdf:rest N6069251b3a8c4f7982d2f0c06b396e98
    120 Nce39a1a7e71b40fb866dad87fe2b760a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Adult
    122 rdf:type schema:DefinedTerm
    123 Nd732503b35284d6ca475f60b14f348df schema:name pubmed_id
    124 schema:value 3899825
    125 rdf:type schema:PropertyValue
    126 Nf2d5aa1f55b44f53b56e679a9116c784 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Middle Aged
    128 rdf:type schema:DefinedTerm
    129 Nfed1500fa19147b7b1b900e7194b11b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Fasting
    131 rdf:type schema:DefinedTerm
    132 Nff0e3d137efb40fca71360b8a67be01e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Insulin Resistance
    134 rdf:type schema:DefinedTerm
    135 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    136 schema:name Medical and Health Sciences
    137 rdf:type schema:DefinedTerm
    138 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    139 schema:name Clinical Sciences
    140 rdf:type schema:DefinedTerm
    141 sg:journal.1001482 schema:issn 0012-186X
    142 1432-0428
    143 schema:name Diabetologia
    144 rdf:type schema:Periodical
    145 sg:person.01015207513.12 schema:affiliation https://www.grid.ac/institutes/grid.8348.7
    146 schema:familyName Treacher
    147 schema:givenName D. F.
    148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015207513.12
    149 rdf:type schema:Person
    150 sg:person.01156637623.46 schema:affiliation https://www.grid.ac/institutes/grid.8348.7
    151 schema:familyName Rudenski
    152 schema:givenName A. S.
    153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156637623.46
    154 rdf:type schema:Person
    155 sg:person.01216556762.76 schema:affiliation https://www.grid.ac/institutes/grid.8348.7
    156 schema:familyName Matthews
    157 schema:givenName D. R.
    158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216556762.76
    159 rdf:type schema:Person
    160 sg:person.014367676652.44 schema:affiliation https://www.grid.ac/institutes/grid.8348.7
    161 schema:familyName Turner
    162 schema:givenName R. C.
    163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014367676652.44
    164 rdf:type schema:Person
    165 sg:person.0627706757.89 schema:affiliation https://www.grid.ac/institutes/grid.8348.7
    166 schema:familyName Naylor
    167 schema:givenName B. A.
    168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627706757.89
    169 rdf:type schema:Person
    170 sg:person.0716551025.95 schema:affiliation https://www.grid.ac/institutes/grid.8348.7
    171 schema:familyName Hosker
    172 schema:givenName J. P.
    173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716551025.95
    174 rdf:type schema:Person
    175 sg:pub.10.1007/bf00280882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028857626
    176 https://doi.org/10.1007/bf00280882
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1007/bf00282705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042771344
    179 https://doi.org/10.1007/bf00282705
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1007/bf00745134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051373300
    182 https://doi.org/10.1007/bf00745134
    183 rdf:type schema:CreativeWork
    184 https://doi.org/10.1016/0026-0495(79)90146-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038472930
    185 rdf:type schema:CreativeWork
    186 https://doi.org/10.1016/0026-0495(83)90024-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049399042
    187 rdf:type schema:CreativeWork
    188 https://doi.org/10.1016/s0140-6736(76)91739-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049185124
    189 rdf:type schema:CreativeWork
    190 https://doi.org/10.1016/s0140-6736(82)91753-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045759419
    191 rdf:type schema:CreativeWork
    192 https://doi.org/10.1111/j.1365-2265.1981.tb00196.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035301559
    193 rdf:type schema:CreativeWork
    194 https://doi.org/10.1152/ajpendo.1979.236.6.e667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080342534
    195 rdf:type schema:CreativeWork
    196 https://doi.org/10.1152/ajpendo.1979.237.3.e214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079974987
    197 rdf:type schema:CreativeWork
    198 https://doi.org/10.1159/000408864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1088682038
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1530/acta.0.0920148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046492738
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.2337/diab.25.12.1154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070732879
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.2337/diab.27.7.701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070733305
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.2337/diab.28.3.227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070733461
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.2337/diab.32.7.617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070734391
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.3109/03091907809161794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048435653
    211 rdf:type schema:CreativeWork
    212 https://www.grid.ac/institutes/grid.8348.7 schema:alternateName John Radcliffe Hospital
    213 schema:name Diabetes Research Laboratories, Radcliffe Infirmary, Oxford, UK
    214 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...