Oxidative polymorphism of dextromethorphan in a Burundi population View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-07

AUTHORS

F. Nsabiyumva, Y. Furet, E. Autret, A. P. Jonville, M. Breteau

ABSTRACT

The wide availability, metabolism by the same cytochrome P 450 as debrisoquine and, above all, the innocuity of dextromethorphan (DMP) favour the frequent choice of this drug as the test substance in determining oxidation phenotypes.100 healthy Burundian volunteers (94 m and 6 f) in this study ingested 50 mg DMP bromhydrate, i.e. 38.5 mg of DMP base. Urine was collected for 8 h following the dose and TLC was used to analyse it. The method was particularly useful in view of its low cost, speed and the ease of applying it to a large study group.5% of the Burundian subjects were poor metabolizers. More... »

PAGES

75-77

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00280112

DOI

http://dx.doi.org/10.1007/bf00280112

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038395330

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1782983


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