Interleukin 1 dose-dependently affects the biosynthesis of (pro)insulin in isolated rat islets of Langerhans View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1987-07

AUTHORS

G. A. Spinas, B. S. Hansen, S. Linde, W. Kastern, J. Mølvig, T. Mandrup-Poulsen, C. A. Dinarello, J. H. Nielsen, J. Nerup

ABSTRACT

Human crude and recombinant interleukin 1 (IL-1) was found to dose- and time-dependently affect the biosynthesis of (pro)insulin in isolated rat islets of Langerhans. Incubation of rat islets with either 0.5 U/ml or 5 U/ml of crude IL-1 for 1 h had no detectable effect on (pro)insulin biosynthesis. After 24 hours of exposure 0.5 U/ml of crude or 0.6 ng/ml of recombinant IL-1 (beta) increased the (pro)insulin biosynthesis by 42% and 58%, respectively, whereas a 10-fold greater concentration of IL-1 decreased the (pro)insulin biosynthesis by 74% and 89%, respectively. The increase in (pro)insulin biosynthesis was accompanied by an increase in total protein biosynthesis indicating a nonspecific stimulatory action of low IL-1 concentrations. In contrast, high IL-1 concentrations caused a more selective decrease of the (pro) insulin biosynthesis when compared to the total protein biosynthesis. In addition, low IL-1 concentrations were found to increase and high concentrations to decrease the relative levels of pre-proinsulin mRNA suggesting that IL-1 may act both at a pre- and post-translational level of insulin biosynthesis. More... »

PAGES

474-480

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00279615

DOI

http://dx.doi.org/10.1007/bf00279615

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033343324

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3311860


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