JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child, Preschool", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diseases in Twins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Dominant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Counseling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heterozygote", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant, Newborn", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pedigree", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retinoblastoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Twins, Monozygotic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wilms Tumor", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Human Genetics, National Institute of Genetics, 411, Mishima, Shizuoka-Ken, Japan", 
          "id": "http://www.grid.ac/institutes/grid.288127.6", 
          "name": [
            "Department of Human Genetics, National Institute of Genetics, 411, Mishima, Shizuoka-Ken, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsunaga", 
        "givenName": "E.", 
        "id": "sg:person.0624606377.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624606377.27"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00281568", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041265256", 
          "https://doi.org/10.1007/bf00281568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00284597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025024243", 
          "https://doi.org/10.1007/bf00284597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/272755a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001067573", 
          "https://doi.org/10.1038/272755a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1981-05", 
    "datePublishedReg": "1981-05-01", 
    "description": "The analyses of published data for Wilms' tumor show the following results:The mode of inheritance of familial cases, which constitute less than 1% of all Wilms' tumors, is autosomal dominant with variable penetrance and expressivity. The familial pattern reveals no evidence that this tumor is associated with a vertically transmitting tumor virus.There is a significant correlation between the first-degree relatives affected with Wilms' tumor in regard to expressivity as measured by the proportion of bilaterally affected or by the age of the patients at diagnosis. In particular, expressivity in the children affected varies consistently with expressivity in the carrier parents, indicating that inherited host resistance plays an important role in the manifestation of the major gene. The average risk of developing Wilms' tumor for offspring of unaffected carriers, who may be regarded as inherently resistant to tumor formation, is estimated at about 0.30. Although the data are limited, the risk for offspring of survivors of hereditary unilateral or bilateral cases may be as high as 0.40 or more. The data from seven pairs of monozygotic twins, including the discordant one associated with del(11 p) and aniridia, are consistent with the host resistance model.In sporadic cases, the proportion of bilateral involvement is about 3%, in contrast with 20% in the familial cases. For bilateral cases, however, the distribution of ages of the patients at diagnosis is virtually the same whether sporadic or familial, and in two-thirds of the cases the disease is already bilateral when the first tumor is noted. These findings suggest that bilateral cases are probably always hereditary. Ages of the patients at diagnosis of sporadic unilateral cases tend to be much higher than in the patients with familial unilateral cases, indicating that most sporadic unilateral cases are nonhereditary. The overall risk for survivors of sporadic unilateral Wilms' tumor to transmit the disease to children may be as low 2\u223c4%.Thus, a number of parallels are found between Wilms' tumor and retinoblastoma. The rate of germinal mutation per locus per generation is estimated at 3\u223c8\u00d710-6 for Wilms' tumor, which does not seem to differ from 8\u223c14\u00d710-6 for retinoblastoma. However, the incidence of nonhereditary Wilms' tumor per newborn is 7\u223c11\u00d710-5, which is about twice that (3\u223c5\u00d710-5) of nonhereditary retinoblastoma. This difference is possibly due to the greater number of cell divisions, resulting in an increased frequency of somatic mutations, of the embryonic cells involved in morphogenesis of the kidney than in the case of retinal development.With increasing success in therapeutic management, it is anticipated that more and more cases of Wilms' tumor inherited from the survivors are emerging. However, even if complete cure of the disease and full recovery of fertility could be achieved for all the patients, about 10 generations may be required to double the present incidence of Wilms' tumor in the population, provided that other conditions remained the same.Some guidelines for genetic counseling in families affected by Wilms' tumor are given.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf00278936", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1085982", 
        "issn": [
          "0340-6717", 
          "1432-1203"
        ], 
        "name": "Human Genetics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "57"
      }
    ], 
    "keywords": [
      "bilateral cases", 
      "unilateral cases", 
      "Wilms tumor", 
      "sporadic unilateral cases", 
      "familial cases", 
      "host resistance models", 
      "first-degree relatives", 
      "unilateral Wilms tumor", 
      "offspring of survivors", 
      "bilateral involvement", 
      "distribution of age", 
      "therapeutic management", 
      "first tumor", 
      "complete cure", 
      "patients", 
      "sporadic cases", 
      "tumors", 
      "present incidence", 
      "average risk", 
      "overall risk", 
      "more cases", 
      "full recovery", 
      "retinal development", 
      "nonhereditary retinoblastoma", 
      "familial pattern", 
      "unaffected carriers", 
      "disease", 
      "diagnosis", 
      "survivors", 
      "genetic counseling", 
      "retinoblastoma", 
      "monozygotic twins", 
      "tumor virus", 
      "significant correlation", 
      "carrier parents", 
      "germinal mutations", 
      "variable penetrance", 
      "somatic mutations", 
      "age", 
      "two-thirds", 
      "incidence", 
      "risk", 
      "mode of inheritance", 
      "host resistance", 
      "children", 
      "sporadic unilateral Wilms' tumor", 
      "offspring", 
      "newborns", 
      "cases", 
      "greater number", 
      "kidney", 
      "proportion", 
      "mutations", 
      "important role", 
      "cure", 
      "manifestations", 
      "virus", 
      "counseling", 
      "aniridia", 
      "Wilms", 
      "embryonic cells", 
      "penetrance", 
      "involvement", 
      "guidelines", 
      "cells", 
      "expressivity", 
      "population", 
      "following results", 
      "findings", 
      "data", 
      "evidence", 
      "management", 
      "relatives", 
      "parents", 
      "differences", 
      "twins", 
      "recovery", 
      "fertility", 
      "number", 
      "role", 
      "major gene", 
      "genes", 
      "contrast", 
      "rate", 
      "correlation", 
      "resistance", 
      "cell division", 
      "regard", 
      "genetics", 
      "family", 
      "frequency", 
      "patterns", 
      "carriers", 
      "development", 
      "inheritance", 
      "success", 
      "varies", 
      "analysis", 
      "morphogenesis", 
      "results", 
      "loci", 
      "generation", 
      "conditions", 
      "division", 
      "parallel", 
      "formation", 
      "model", 
      "number of parallels", 
      "distribution", 
      "resistance model", 
      "pairs", 
      "mode"
    ], 
    "name": "Genetics of Wilms' tumor", 
    "pagination": "231-246", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1017313002"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00278936"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "6265341"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00278936", 
      "https://app.dimensions.ai/details/publication/pub.1017313002"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_172.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf00278936"
  }
]

Download the RDF metadata as:  json-ld nt turtle xml License info

This table displays all metadata directly associated to this object as RDF triples.

273 TRIPLES      21 PREDICATES      163 URIs      152 LITERALS      29 BLANK NODES