ω-Halofatty acids: A probe for mitochondrial membrane integrity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-07

AUTHORS

Gerd Kloster, Gerhard Stöcklin, Edward F. Smith, Karsten Schrör

ABSTRACT

Long-chain omega-halofatty acids, especially omega-123I-iodoheptadecanoic acid (IHA), are widely used clinically as radiopharmaceuticals for functional heart imaging. The metabolic interpretation of the various elimination rates, however, remains in dispute. It has been previously shown (Kloster and Stöcklin 1982) that in isolated perfused guinea-pig hearts halide diffusion from the mitochondrion to the blood is the rate-determining step of IHA pharmacokinetics in normal myocardium. We have now extended these in vitro experiments to normal and globally ischaemic isolated perfused rabbit hearts. Again, in normal hearts a single phase iodide elimination half-time (14.3 +/- 2.1 min) was observed. In hearts made globally ischaemic for 90 min, the iodide elimination was biphasic with a first fast phase (T 1/2 = 3.8 +/- 0.49 min) and a late slow phase (T 1/2 = 60.5 +/- 14.0 min). The first fast phase is attributed to iodide ion released by residual beta-oxidation (more rapid than in normal hearts due to damaged membranes in ischaemia), while the late slow phase is explained by beta-oxidation of IHA slowly released by hydrolysis of intracellular lipid stores. These data were compared with published data from investigations in patients which seem to support our interpretation. More... »

PAGES

305-311

References to SciGraph publications

  • 1981-09. Dynamic myocardial scintigraphy with 123I-labeled free fatty acids in patients with myocardial infarction in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1981-09. Metabolic myocardial imaging with 123I-labeled heptadecanoic acid in patients with angina pectoris in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1983-05. Myocardial kinetics of 123I-labeled-16-hexadecanoic acid in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00276459

    DOI

    http://dx.doi.org/10.1007/bf00276459

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1028116098

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6468423


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