Reduced protection against hepatitis B virus following vaccination in patients with Type 1 (insulin-dependent) diabetes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1987-10

AUTHORS

P. Pozzilli, P. Arduini, N. Visalli, J. Sutherland, M. Pezzella, C. Galli, S. G. Corradini, L. Biasio, E. A. M. Gale, D. Andreani

ABSTRACT

Twenty patients with well controlled Type 1 (insulin-dependent) diabetes of at least 10 years duration and 47 control subjects were vaccinated against the hepatitis B virus using the Hevac B vaccine. The vaccine was administered into the deltoid region on three occasions at intervals of 1 month. Thereafter a fourth dose was given to subjects still negative for antibody to hepatitis B surface antigen (HbsAb). The median rise of HbsAb titres was 230 mIU/ml in normal subjects and 50 mIU/ml in diabetic patients (p less than 0.001). Eight patients (40%) failed to reach HbsAb titres above 30 mIU/ml, the level considered to give optimal protection against the infection, whereas only one normal control subject failed to reach this level. Five patients (25%) showed no response despite a fourth dose of the vaccine. There was an increased frequency of HLA-DR7 in low responders and a decreased (less than 1.5) helper/suppressor lymphocyte ratio. Diabetic patients are thus less likely to mount a protective antibody response following vaccination against hepatitis. Since hepatitis B surface antigen is reported to be considerably more common in diabetic patients than control subjects, infection with hepatitis B virus may have a greater risk of chronicity in diabetes. More... »

PAGES

817-819

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00275749

DOI

http://dx.doi.org/10.1007/bf00275749

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002687211

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2962892


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