Prospective study of lymphocyte subsets in subjects genetically susceptible to Type 1 (insulin-dependent) diabetes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1984-07

AUTHORS

P. Pozzilli, M. Sensi, L. Al-Sakkaf, A. Tarn, O. Zuccarini, G. F. Bottazzo

ABSTRACT

A prospective study of lymphocyte subsets has been carried out for 18 months in 58 healthy first-degree relatives of Type 1 (insulin-dependent) probands. Subjects selected for presence or absence of islet cell antibodies included 10 with complement-fixing islet cell antibodies, 10 with conventional islet cell antibodies and 38 without islet cell antibodies. Immunoregulatory and effector lymphocytes subsets, and in particular activated T-cells, were investigated using a panel of monoclonal antibodies. The results showed no significant changes in total T, helper, suppressor/cytotoxic cell or K/NK cells. Activated T-cells were observed at least once in 22 subjects using the 4F2 monoclonal antibody and in 11 using the Tac antibody. Seven subjects had 4F2-positive cells on repeated occasions and one twice showed Tac-positive cells. Fluctuations and/or loss of islet cell antibodies were observed during follow-up. There was no correlation between presence of activated T-cells and either islet cell antibody status of HLA haplotype sharing with the diabetic proband. On the other hand, a significant correlation was observed between HLA-DR3 positivity of subjects and the occurrence of activated T-cells (both 4F2-positive and Tac-positive). We conclude that subjects with HLA-DR3 may be especially prone to T-cell activation. As none of the 'high risk' individuals developed diabetes in the course of follow-up, the relevance of these observations in the pathogenesis of Type 1 diabetes needs more prolonged investigation. More... »

PAGES

132-135

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00275670

DOI

http://dx.doi.org/10.1007/bf00275670

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008198878

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6332754


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