Ontology type: schema:ScholarlyArticle
1988-12
AUTHORSNguyen van Cong, G. Uzan, M. S. Gross, C. Jegou-Foubert, P. Frachet, C. Boucheix, G. Marguerie, J. Frézal
ABSTRACTThe platelet GPIIb-IIIa complex functions as a receptor for fibrinogen, fibronectin, and von Willebrand factor on activated platelets. This glycoprotein is a member of a broadly distributed family of structurally and immunologically related membrane receptors involved in cell-cell contact and cell-matrices interactions. GPIIb-IIIa is a heterodimer complex composed of GPIIb (the alpha subunit), which consists of two disulfide-linked heavy and light chains, and GPIIIa (the beta subunit), which is a single polypeptide chain. Congenital absence of platelet GPIIb-IIIa in Glanzmann's thrombasthenia results in a severe bleeding disorder characterized by defective platelet aggregation and failure of fibrinogen to bind to platelets. The gene coding for GPIIb was located on 17q21.1-17q21.3 as determined by in situ hybridization with a 2650-bp GP2B (GPIIb) cDNA probe prepared from human megakaryocytes. More... »
PAGES389-392
http://scigraph.springernature.com/pub.10.1007/bf00273658
DOIhttp://dx.doi.org/10.1007/bf00273658
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