Transient expression of foreign DNA during embryonic and larval development of the medaka fish (Oryzias latipes) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1991-04

AUTHORS

Christoph Winkler, Jürgen R. Vielkind, Manfred Schartl

ABSTRACT

Species of small fish are becoming useful tools for studies on vertebrate development. We have investigated the developing embryo of the Japanese medaka for its application as a transient expression system for the in vivo analysis of gene regulation and function. The temporal and spatial expression patterns of bacterial chloramphenicol acetyltransferase and galactosidase reporter genes injected in supercoiled plasmid form into the cytoplasm of one cell of the two-cell stage embryo was promoter-specific. The transient expression was found to be mosaic within the tissue and organs reflecting the unequal distribution of extrachromosomal foreign DNA and the intensive cell mixing movements that occur in fish embryogenesis. The expression data are consistent with data on DNA fate. Foreign DNA persisted during embryogenesis and was still detectable in some 3- and 9-month-old adult fish; it was found in high molecular weight form as well as in circular plasmid conformations. The DNA was replicated during early and late embryogenesis. Our data indicate that the developing medaka embryo is a powerful in vivo assay system for studies of gene regulation and function. More... »

PAGES

129-140

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00273596

DOI

http://dx.doi.org/10.1007/bf00273596

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007008702

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1903501


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00273596'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00273596'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00273596'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00273596'


 

This table displays all metadata directly associated to this object as RDF triples.

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