Bioavailability of ifosfamide in patients with bronchial carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-12

AUTHORS

T. Cerny, J. M. Margison, N. Thatcher, P. M. Wilkinson

ABSTRACT

The pharmacokinetics of ifosfamide (I) were determined in ten patients with bronchogenic carcinoma. In seven patients, doses of 1 and 2 g (I) were given both as a bolus orally and later intravenously and were well tolerated. A further three patients received 5 g (I) as a single oral dose but in two this produced reversible CNS toxicity and severe vomiting. The area under the curve (AUC, microgram . h . l-1) for the 1-g dose was the same following oral and i.v. treatment and this was also true for the 2-g doses. There was a proportionate increase in the AUC for the 5-g oral dose, indicating 100% bioavailability at all three dose levels. We conclude that doses up to 2 g by mouth represent a well-tolerated alternative route of administration. More... »

PAGES

261-264

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00273399

DOI

http://dx.doi.org/10.1007/bf00273399

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006457921

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3802382


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