DNA polymerase α inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-07

AUTHORS

Thomas W. Glover, Carol Berger, Jane Coyle, Barbara Echo

ABSTRACT

Aphidicolin, a specific inhibitor of DNA polymerase alpha, is known to induce chromosomal aberrations. At concentrations that did not greatly affect mitotic index, aphidicolin induced a striking number of chromosome gaps and breaks distributed in a highly nonrandom manner in cultured human lymphocytes. Specific chromosome bands, especially 2q31, 3p14, 6q26, 7q32, 16q23, and Xp22 were preferentially damaged in lymphocytes from each of 12 subjects studied. Total and site-specific damage was dose dependent and greatly increased when folic acid was removed from the medium. The sites most sensitive to aphidicolin damage include the "hot spots" seen under conditions of thymidylate stress and in studies of spontaneous chromosomal damage. The fragile X site, which can also be induced by thymidylate stress, was not induced by aphidicolin in lymphocytes, suggesting a separate mechanism for its induction. Aphidicolin represents a novel tool for detection of hot spots on human chromosomes through the mechanism of DNA polymerase alpha inhibition. The hot spots induced by aphidicolin represent a new class of fragile sites which we term common fragile sites. More... »

PAGES

136-142

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00272988

DOI

http://dx.doi.org/10.1007/bf00272988

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031783252

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6430783


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aphidicolin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Banding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Fragile Sites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Fragility", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Culture Media", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Polymerase II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diterpenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "The Genetics Center of Southwest Biomedical Research Institute, 123 East University Drive, 85281, Tempe, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Glover", 
        "givenName": "Thomas W.", 
        "id": "sg:person.0734760120.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734760120.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "The Genetics Center of Southwest Biomedical Research Institute, 123 East University Drive, 85281, Tempe, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berger", 
        "givenName": "Carol", 
        "id": "sg:person.01151177275.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151177275.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "The Genetics Center of Southwest Biomedical Research Institute, 123 East University Drive, 85281, Tempe, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coyle", 
        "givenName": "Jane", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "The Genetics Center of Southwest Biomedical Research Institute, 123 East University Drive, 85281, Tempe, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Echo", 
        "givenName": "Barbara", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1111/j.1601-5223.1983.tb00608.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002662804", 
          "https://doi.org/10.1111/j.1601-5223.1983.tb00608.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-4608(82)90077-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003051404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.80.13.3996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003779749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00293069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003864356", 
          "https://doi.org/10.1007/bf00293069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0074-7696(08)62336-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004814455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00284670", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008483481", 
          "https://doi.org/10.1007/bf00284670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(79)91833-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008523515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00296144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009482163", 
          "https://doi.org/10.1007/bf00296144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0027-5107(80)90029-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010067517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(81)91672-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010555041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000129958", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011799558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/304086a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011940761", 
          "https://doi.org/10.1038/304086a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(81)90730-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013758391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.bi.49.070180.003211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016414886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/275458a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016490252", 
          "https://doi.org/10.1038/275458a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/275458a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016490252", 
          "https://doi.org/10.1038/275458a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/275458a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016490252", 
          "https://doi.org/10.1038/275458a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/7.5.1205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019352070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00279409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024606641", 
          "https://doi.org/10.1007/bf00279409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00279409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024606641", 
          "https://doi.org/10.1007/bf00279409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-4781(83)90039-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027979161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-4781(83)90039-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027979161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jmg.18.5.374", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029588707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0027-5107(82)90237-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030007651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/8.2.377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032479774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-4608(84)90132-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033493088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000130485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034803104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000131621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035658759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1601-5223.1975.tb01507.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036730657", 
          "https://doi.org/10.1111/j.1601-5223.1975.tb01507.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00291497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040143470", 
          "https://doi.org/10.1007/bf00291497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1982.tb06492.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041831828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajmg.1320160105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042114270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajmg.1320160105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042114270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000131620", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042638190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/em.2860040609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048261359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.6336310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062636827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079890991", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081725704", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081753111", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082140255", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1984-07", 
    "datePublishedReg": "1984-07-01", 
    "description": "Aphidicolin, a specific inhibitor of DNA polymerase alpha, is known to induce chromosomal aberrations. At concentrations that did not greatly affect mitotic index, aphidicolin induced a striking number of chromosome gaps and breaks distributed in a highly nonrandom manner in cultured human lymphocytes. Specific chromosome bands, especially 2q31, 3p14, 6q26, 7q32, 16q23, and Xp22 were preferentially damaged in lymphocytes from each of 12 subjects studied. Total and site-specific damage was dose dependent and greatly increased when folic acid was removed from the medium. The sites most sensitive to aphidicolin damage include the \"hot spots\" seen under conditions of thymidylate stress and in studies of spontaneous chromosomal damage. The fragile X site, which can also be induced by thymidylate stress, was not induced by aphidicolin in lymphocytes, suggesting a separate mechanism for its induction. Aphidicolin represents a novel tool for detection of hot spots on human chromosomes through the mechanism of DNA polymerase alpha inhibition. The hot spots induced by aphidicolin represent a new class of fragile sites which we term common fragile sites.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00272988", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2466408", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1085982", 
        "issn": [
          "0340-6717", 
          "1432-1203"
        ], 
        "name": "Human Genetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "67"
      }
    ], 
    "name": "DNA polymerase \u03b1 inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes", 
    "pagination": "136-142", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9768b9b1f38bd033ea511f97d2ca69d1ad01d075d5631363076d8da2ddc9f7e8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "6430783"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7613873"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00272988"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031783252"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00272988", 
      "https://app.dimensions.ai/details/publication/pub.1031783252"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130829_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF00272988"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00272988'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00272988'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00272988'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00272988'


 

This table displays all metadata directly associated to this object as RDF triples.

257 TRIPLES      21 PREDICATES      77 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00272988 schema:about N043e1857dafe45758dd9f67698c216fd
2 N4367d030f34c418b844e2f30b0387b63
3 N470e78adc93c49c9b1dd2320d8246d93
4 N473070d380ed426b841010687d43ebf1
5 N75cbb04343c74d6992b6f1ae54806120
6 N79bef3229eca4055a64ecd2bea43ef20
7 N8caff6900dc847d6bbfd9f7baa4f077a
8 Na2cf9b38c2024ed3b022a39027f46dca
9 Na4b949fb207c464b8a9fc33db13aa7fc
10 Na713f0ceca4e49a698622d01aef8aefc
11 Ncb40bac5098548a7ab9656f8435929a6
12 Ne02dae9e193a4482b4d548baf9780ef8
13 Ne43960c9bc894518ab2c3c876be357e6
14 anzsrc-for:06
15 anzsrc-for:0604
16 schema:author N32e79a18dc904d04965311731eb95571
17 schema:citation sg:pub.10.1007/bf00279409
18 sg:pub.10.1007/bf00284670
19 sg:pub.10.1007/bf00291497
20 sg:pub.10.1007/bf00293069
21 sg:pub.10.1007/bf00296144
22 sg:pub.10.1038/275458a0
23 sg:pub.10.1038/304086a0
24 sg:pub.10.1111/j.1601-5223.1975.tb01507.x
25 sg:pub.10.1111/j.1601-5223.1983.tb00608.x
26 https://app.dimensions.ai/details/publication/pub.1079890991
27 https://app.dimensions.ai/details/publication/pub.1081725704
28 https://app.dimensions.ai/details/publication/pub.1081753111
29 https://app.dimensions.ai/details/publication/pub.1082140255
30 https://doi.org/10.1002/ajmg.1320160105
31 https://doi.org/10.1002/em.2860040609
32 https://doi.org/10.1016/0006-291x(79)91833-3
33 https://doi.org/10.1016/0006-291x(81)90730-0
34 https://doi.org/10.1016/0006-291x(81)91672-7
35 https://doi.org/10.1016/0027-5107(80)90029-9
36 https://doi.org/10.1016/0027-5107(82)90237-8
37 https://doi.org/10.1016/0165-4608(82)90077-2
38 https://doi.org/10.1016/0165-4608(84)90132-8
39 https://doi.org/10.1016/0167-4781(83)90039-8
40 https://doi.org/10.1016/s0074-7696(08)62336-0
41 https://doi.org/10.1073/pnas.80.13.3996
42 https://doi.org/10.1093/nar/7.5.1205
43 https://doi.org/10.1093/nar/8.2.377
44 https://doi.org/10.1111/j.1432-1033.1982.tb06492.x
45 https://doi.org/10.1126/science.6336310
46 https://doi.org/10.1136/jmg.18.5.374
47 https://doi.org/10.1146/annurev.bi.49.070180.003211
48 https://doi.org/10.1159/000129958
49 https://doi.org/10.1159/000130485
50 https://doi.org/10.1159/000131620
51 https://doi.org/10.1159/000131621
52 schema:datePublished 1984-07
53 schema:datePublishedReg 1984-07-01
54 schema:description Aphidicolin, a specific inhibitor of DNA polymerase alpha, is known to induce chromosomal aberrations. At concentrations that did not greatly affect mitotic index, aphidicolin induced a striking number of chromosome gaps and breaks distributed in a highly nonrandom manner in cultured human lymphocytes. Specific chromosome bands, especially 2q31, 3p14, 6q26, 7q32, 16q23, and Xp22 were preferentially damaged in lymphocytes from each of 12 subjects studied. Total and site-specific damage was dose dependent and greatly increased when folic acid was removed from the medium. The sites most sensitive to aphidicolin damage include the "hot spots" seen under conditions of thymidylate stress and in studies of spontaneous chromosomal damage. The fragile X site, which can also be induced by thymidylate stress, was not induced by aphidicolin in lymphocytes, suggesting a separate mechanism for its induction. Aphidicolin represents a novel tool for detection of hot spots on human chromosomes through the mechanism of DNA polymerase alpha inhibition. The hot spots induced by aphidicolin represent a new class of fragile sites which we term common fragile sites.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree false
58 schema:isPartOf N7fb1b8217a4041d2aa54d93528f31251
59 N8693c8b5d7b1438e9d9c5dbcef5d275b
60 sg:journal.1085982
61 schema:name DNA polymerase α inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes
62 schema:pagination 136-142
63 schema:productId N3c40fe59b8cd4d83b7601c82d67b6dd8
64 N56939a30d5af484bb1a7194bb7ae97a2
65 N6a770f6a23884ed4ae877fcb9e377c68
66 N6f56ca03ed9844c985433610a5ec9771
67 N873d4ca9ac4a45858f09b220c4b71f6b
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031783252
69 https://doi.org/10.1007/bf00272988
70 schema:sdDatePublished 2019-04-11T14:00
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher Ne20071e5a2b04cff9dfa81940a0afab9
73 schema:url http://link.springer.com/10.1007/BF00272988
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N043e1857dafe45758dd9f67698c216fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Aphidicolin
79 rdf:type schema:DefinedTerm
80 N1cf093fad8bc4882af04c9d6f2ff296d rdf:first Nfc8ce7d0a99d4ee5bf51394344d34158
81 rdf:rest N2cca2312ad5b4c02b032c2e32eeee015
82 N1df863899047467aa33499b259dfbd37 rdf:first sg:person.01151177275.44
83 rdf:rest N1cf093fad8bc4882af04c9d6f2ff296d
84 N2cca2312ad5b4c02b032c2e32eeee015 rdf:first N446e72882b3d408a87e62eed5b066664
85 rdf:rest rdf:nil
86 N32e79a18dc904d04965311731eb95571 rdf:first sg:person.0734760120.41
87 rdf:rest N1df863899047467aa33499b259dfbd37
88 N3c40fe59b8cd4d83b7601c82d67b6dd8 schema:name nlm_unique_id
89 schema:value 7613873
90 rdf:type schema:PropertyValue
91 N40b128ffec704838b08828d35aa5089d schema:name The Genetics Center of Southwest Biomedical Research Institute, 123 East University Drive, 85281, Tempe, AZ, USA
92 rdf:type schema:Organization
93 N4367d030f34c418b844e2f30b0387b63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Chromosome Banding
95 rdf:type schema:DefinedTerm
96 N446e72882b3d408a87e62eed5b066664 schema:affiliation Ndc0121c47a784149babfd2fb773529bd
97 schema:familyName Echo
98 schema:givenName Barbara
99 rdf:type schema:Person
100 N470e78adc93c49c9b1dd2320d8246d93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Diterpenes
102 rdf:type schema:DefinedTerm
103 N473070d380ed426b841010687d43ebf1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Chromosome Fragile Sites
105 rdf:type schema:DefinedTerm
106 N56939a30d5af484bb1a7194bb7ae97a2 schema:name dimensions_id
107 schema:value pub.1031783252
108 rdf:type schema:PropertyValue
109 N6a770f6a23884ed4ae877fcb9e377c68 schema:name pubmed_id
110 schema:value 6430783
111 rdf:type schema:PropertyValue
112 N6f56ca03ed9844c985433610a5ec9771 schema:name doi
113 schema:value 10.1007/bf00272988
114 rdf:type schema:PropertyValue
115 N75cbb04343c74d6992b6f1ae54806120 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Chromosome Fragility
117 rdf:type schema:DefinedTerm
118 N79bef3229eca4055a64ecd2bea43ef20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Cells, Cultured
120 rdf:type schema:DefinedTerm
121 N7fb1b8217a4041d2aa54d93528f31251 schema:issueNumber 2
122 rdf:type schema:PublicationIssue
123 N8693c8b5d7b1438e9d9c5dbcef5d275b schema:volumeNumber 67
124 rdf:type schema:PublicationVolume
125 N873d4ca9ac4a45858f09b220c4b71f6b schema:name readcube_id
126 schema:value 9768b9b1f38bd033ea511f97d2ca69d1ad01d075d5631363076d8da2ddc9f7e8
127 rdf:type schema:PropertyValue
128 N8caff6900dc847d6bbfd9f7baa4f077a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Lymphocytes
130 rdf:type schema:DefinedTerm
131 Na2cf9b38c2024ed3b022a39027f46dca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Humans
133 rdf:type schema:DefinedTerm
134 Na4b949fb207c464b8a9fc33db13aa7fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Culture Media
136 rdf:type schema:DefinedTerm
137 Na713f0ceca4e49a698622d01aef8aefc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Chromosomes, Human
139 rdf:type schema:DefinedTerm
140 Nc812894f2642496e9f5088f357889fb6 schema:name The Genetics Center of Southwest Biomedical Research Institute, 123 East University Drive, 85281, Tempe, AZ, USA
141 rdf:type schema:Organization
142 Ncb40bac5098548a7ab9656f8435929a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Female
144 rdf:type schema:DefinedTerm
145 Ndc0121c47a784149babfd2fb773529bd schema:name The Genetics Center of Southwest Biomedical Research Institute, 123 East University Drive, 85281, Tempe, AZ, USA
146 rdf:type schema:Organization
147 Ndf362c3ff9ed4393a4ff32e337050aba schema:name The Genetics Center of Southwest Biomedical Research Institute, 123 East University Drive, 85281, Tempe, AZ, USA
148 rdf:type schema:Organization
149 Ne02dae9e193a4482b4d548baf9780ef8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name DNA Polymerase II
151 rdf:type schema:DefinedTerm
152 Ne20071e5a2b04cff9dfa81940a0afab9 schema:name Springer Nature - SN SciGraph project
153 rdf:type schema:Organization
154 Ne43960c9bc894518ab2c3c876be357e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Male
156 rdf:type schema:DefinedTerm
157 Nfc8ce7d0a99d4ee5bf51394344d34158 schema:affiliation N40b128ffec704838b08828d35aa5089d
158 schema:familyName Coyle
159 schema:givenName Jane
160 rdf:type schema:Person
161 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
162 schema:name Biological Sciences
163 rdf:type schema:DefinedTerm
164 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
165 schema:name Genetics
166 rdf:type schema:DefinedTerm
167 sg:grant.2466408 http://pending.schema.org/fundedItem sg:pub.10.1007/bf00272988
168 rdf:type schema:MonetaryGrant
169 sg:journal.1085982 schema:issn 0340-6717
170 1432-1203
171 schema:name Human Genetics
172 rdf:type schema:Periodical
173 sg:person.01151177275.44 schema:affiliation Ndf362c3ff9ed4393a4ff32e337050aba
174 schema:familyName Berger
175 schema:givenName Carol
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151177275.44
177 rdf:type schema:Person
178 sg:person.0734760120.41 schema:affiliation Nc812894f2642496e9f5088f357889fb6
179 schema:familyName Glover
180 schema:givenName Thomas W.
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734760120.41
182 rdf:type schema:Person
183 sg:pub.10.1007/bf00279409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024606641
184 https://doi.org/10.1007/bf00279409
185 rdf:type schema:CreativeWork
186 sg:pub.10.1007/bf00284670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008483481
187 https://doi.org/10.1007/bf00284670
188 rdf:type schema:CreativeWork
189 sg:pub.10.1007/bf00291497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040143470
190 https://doi.org/10.1007/bf00291497
191 rdf:type schema:CreativeWork
192 sg:pub.10.1007/bf00293069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003864356
193 https://doi.org/10.1007/bf00293069
194 rdf:type schema:CreativeWork
195 sg:pub.10.1007/bf00296144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009482163
196 https://doi.org/10.1007/bf00296144
197 rdf:type schema:CreativeWork
198 sg:pub.10.1038/275458a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016490252
199 https://doi.org/10.1038/275458a0
200 rdf:type schema:CreativeWork
201 sg:pub.10.1038/304086a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011940761
202 https://doi.org/10.1038/304086a0
203 rdf:type schema:CreativeWork
204 sg:pub.10.1111/j.1601-5223.1975.tb01507.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036730657
205 https://doi.org/10.1111/j.1601-5223.1975.tb01507.x
206 rdf:type schema:CreativeWork
207 sg:pub.10.1111/j.1601-5223.1983.tb00608.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002662804
208 https://doi.org/10.1111/j.1601-5223.1983.tb00608.x
209 rdf:type schema:CreativeWork
210 https://app.dimensions.ai/details/publication/pub.1079890991 schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1081725704 schema:CreativeWork
212 https://app.dimensions.ai/details/publication/pub.1081753111 schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1082140255 schema:CreativeWork
214 https://doi.org/10.1002/ajmg.1320160105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042114270
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1002/em.2860040609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048261359
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/0006-291x(79)91833-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008523515
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/0006-291x(81)90730-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013758391
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/0006-291x(81)91672-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010555041
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/0027-5107(80)90029-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010067517
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/0027-5107(82)90237-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030007651
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/0165-4608(82)90077-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003051404
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/0165-4608(84)90132-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033493088
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/0167-4781(83)90039-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027979161
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/s0074-7696(08)62336-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004814455
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1073/pnas.80.13.3996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003779749
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1093/nar/7.5.1205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019352070
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1093/nar/8.2.377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032479774
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1111/j.1432-1033.1982.tb06492.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041831828
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1126/science.6336310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062636827
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1136/jmg.18.5.374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029588707
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1146/annurev.bi.49.070180.003211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016414886
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1159/000129958 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011799558
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1159/000130485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034803104
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1159/000131620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042638190
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1159/000131621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035658759
257 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...