A new conditional lethal mutator (dnaQ49) in Escherichia coli K12 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1978-01

AUTHORS

Takashi Horiuchi, Hisaji Maki, Mutsuo Sekiguchi

ABSTRACT

A conditional lethal mutator, dnaQ49, was found in Escherichia coli K12. The dnaQ49 mutation caused stimulation of rifampicin-, nalidixic acid- and streptomycin-resistant mutation frequencies 100 to 2000 fold at 30°C and the frequencies were further increased 50 to 100 fold at 35°C or higher temperatures. Cells carrying dnaQ49 were unable to grown in salt-free L-broth at 44.5°C, and DNA synthesis but not protein synthesis of the cells was suppressed under the restrictive conditions. The dnaQ gene was located at about 5 min on the E. coli linkage map and the order of the genes residing in this region was determined to be on A-dnaE-metD-dnaQ-proA. More... »

PAGES

277-283

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00271956

DOI

http://dx.doi.org/10.1007/bf00271956

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008276151

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/355854


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