Inactivation kinetics of Lambda phage repressors in a mutant of E. coli temperature sensitive in DNA replication View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1972-09

AUTHORS

Dieter Noack, Siegfried Klaus

ABSTRACT

The inactivation kinetics of two different Lambda phage repressors in lysogenic complexes of an E. coli strain temperature sensitive in DNA synthesis is investigated. From the experimental data obtained it is inferred thatafter a stop of DNA synthesis effector molecules are accumulated which give rise to the inactivation of phage repressors directly,the accumulation kinetics of the effector molecules after a stop of DNA synthesis is similar to that kinetics which must be expected from accumulation of DNA precursors.The inactivation of λ+ and λind8repressor molecules begins 20 min and 5 min, respectively, after the stop of host DNA synthesis.The effector concentration is rapidly diminished after restoration of DNA synthesis,the accumulation of effector molecules proceeds without protein synthesis in this strain after temperature shift up.The effector substance seems not to be a protein. More... »

PAGES

216-224

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00268885

DOI

http://dx.doi.org/10.1007/bf00268885

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024570808

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4555676


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