Suppression of erythromycin resistance in ery-M1 mutants of Chlamydomonas reinhardi View Full Text


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Article Info

DATE

1977-01

AUTHORS

Jeffrey N. Davidson, Lawrence Bogorad

ABSTRACT

After mutagenesis of the erythromycin-resistant Chlamydomonas reinhardi strain ery-M1b, four mutants were isolated, each more sensitive to erythromycin than ery-M1b. All four mutants carry the original ery-M1b mutation which confers resistance and a separate mutation (es) which partially suppresses resistance. The mutants are designated es5ery-M1b, es101ery-M1b, es105ery-M1b, and es115ery-M1b. The suppressor mutations represent at least three different Mendelian loci. The suppressor es101 is located on the same linkage group as ery-M1, while the other suppressors are not linked to ery-M1. Although some of these suppressors can also mask the erythromycin resistance of ery-M2 strains, none had any effect on the non-Mendelian mutant ery-Ula. In addition, each suppressor affected the cross-resistance of ery-M1 mutants to other antibiotics. At least two of the changes in cross-resistance are due solely to the suppressor. Chloroplast ribosomes from cells carrying es5ery-M1b, es101ery-M1b, and es115ery-M1b have a greater affinity for 14C-erythromycin in vitro than those from ery-M1b. The degree of affinity depends upon the concentration of KCl. Each of these Mendelian suppressors probably affects a chloroplast ribosome function. Hence, a number of nuclear genes must play roles in the biogenesis of the chloroplast ribosome in Chlamydomonas reinhardi. More... »

PAGES

39-46

References to SciGraph publications

  • 1970-12. Ribosomal proteins in MOLECULAR GENETICS AND GENOMICS
  • 1970-12. Reversion of a streptomycin-dependent strain ofEscherichia coli in MOLECULAR GENETICS AND GENOMICS
  • 1969-04. Identification and Functional Characterization of the Protein controlled by the Streptomycin-resistant Locus in E. coli in NATURE
  • 1973-03. Amino acid replacements in proteins S5 and S12 of two Escherichia coli revertants from streptomycin dependence to independence in MOLECULAR GENETICS AND GENOMICS
  • 1973-03. Electrophoretic and immunological studies on ribosomal proteins of 100 Escherichia coli revertants from streptomycin dependence in MOLECULAR GENETICS AND GENOMICS
  • 1972-06. Ribosomal proteins in MOLECULAR GENETICS AND GENOMICS
  • 1974-09. Functional interdependence among ribosomal elements as revealed by genetic analysis in MOLECULAR GENETICS AND GENOMICS
  • 1972-03. Changes in the primary structure of a mutationally altered ribosomal protein S 4 of Escherichia coli in MOLECULAR GENETICS AND GENOMICS
  • 1973-06. Biochemical and genetic studies on two different types of erythromycin resistant mutants of Escherichia coli with altered ribosomal proteins in MOLECULAR GENETICS AND GENOMICS
  • 1975. Biochemistry of Antimicrobial Action in NONE
  • 1974-06. An altered chloroplast ribosomal protein in ery-M1 mutants of Chlamydomonas reinhardi in MOLECULAR GENETICS AND GENOMICS
  • 1971-12. Ribosomal proteins in MOLECULAR GENETICS AND GENOMICS
  • 1977-01. Complementation analysis at the ery-M1 locus in Chlamydomonas reinhardi in MOLECULAR GENETICS AND GENOMICS
  • 1977. The Genetics of the Chloroplast Ribosome in Chlamydomonas reinhardi in NUCLEIC ACIDS AND PROTEIN SYNTHESIS IN PLANTS
  • 1974-03. Functional interdependence of 50S and 30S ribosomal subunits in MOLECULAR GENETICS AND GENOMICS
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/bf00268685

    DOI

    http://dx.doi.org/10.1007/bf00268685

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/600267


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