Mutational specificity of a conditional Escherichia coli mutator, mutD5 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1974-09

AUTHORS

Robert G. Fowler, Gerald E. Degnen, Edward C. Cox

ABSTRACT

MutD5, a conditional mutator in Escherichia coli, causes the stimulation of mutation frequencies 50 to 100 fold in minimal medium. In rich medium mutation frequencies are further increased 50 to 100 fold. We show here that all possible base-pair mutations are increased in a mutD5 strain grown in rich medium. A:T↔G:C transitions as well as A:T↔C:G, A:T↔T:A aud G:C↔C:G transversions are stimulated. Transitions occur more frequently than transversions. MutD5 also increases the reversion frequencies of three trpA frameshift mutations by causing base-pair additions, and, possibly, base-pair deletions. More... »

PAGES

179-191

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00267667

DOI

http://dx.doi.org/10.1007/bf00267667

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013207360

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4614067


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Aberrations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Escherichia coli", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetics, Microbial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Species Specificity", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Biochemical Sciences, Princeton University, Princeton, N. J., USA", 
          "id": "http://www.grid.ac/institutes/grid.16750.35", 
          "name": [
            "Department of Biology, Princeton University, Princeton, N. J., USA", 
            "Department of Biochemical Sciences, Princeton University, Princeton, N. J., USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fowler", 
        "givenName": "Robert G.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Human Genetics, Yale University, 06510, New Haven, Conn., USA", 
          "id": "http://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Biology, Princeton University, Princeton, N. J., USA", 
            "Department of Biochemical Sciences, Princeton University, Princeton, N. J., USA", 
            "Department of Human Genetics, Yale University, 06510, New Haven, Conn., USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Degnen", 
        "givenName": "Gerald E.", 
        "id": "sg:person.0113476226.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0113476226.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemical Sciences, Princeton University, Princeton, N. J., USA", 
          "id": "http://www.grid.ac/institutes/grid.16750.35", 
          "name": [
            "Department of Biology, Princeton University, Princeton, N. J., USA", 
            "Department of Biochemical Sciences, Princeton University, Princeton, N. J., USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cox", 
        "givenName": "Edward C.", 
        "id": "sg:person.01224726520.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224726520.36"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/newbio236019a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029463330", 
          "https://doi.org/10.1038/newbio236019a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00267054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019362511", 
          "https://doi.org/10.1007/bf00267054"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1974-09", 
    "datePublishedReg": "1974-09-01", 
    "description": "MutD5, a conditional mutator in Escherichia coli, causes the stimulation of mutation frequencies 50 to 100 fold in minimal medium. In rich medium mutation frequencies are further increased 50 to 100 fold. We show here that all possible base-pair mutations are increased in a mutD5 strain grown in rich medium. A:T\u2194G:C transitions as well as A:T\u2194C:G, A:T\u2194T:A aud G:C\u2194C:G transversions are stimulated. Transitions occur more frequently than transversions. MutD5 also increases the reversion frequencies of three trpA frameshift mutations by causing base-pair additions, and, possibly, base-pair deletions.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf00267667", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1297380", 
        "issn": [
          "1617-4615", 
          "1432-1874"
        ], 
        "name": "Molecular Genetics and Genomics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "133"
      }
    ], 
    "keywords": [
      "base pair addition", 
      "Escherichia coli mutator", 
      "base pair mutation", 
      "minimal medium", 
      "mutD5 strain", 
      "rich medium", 
      "base pair deletion", 
      "mutational specificity", 
      "Escherichia coli", 
      "reversion frequency", 
      "frameshift mutation", 
      "mutator", 
      "mutation frequency", 
      "mutD5", 
      "mutations", 
      "transversions", 
      "folds", 
      "coli", 
      "deletion", 
      "strains", 
      "specificity", 
      "medium", 
      "stimulation", 
      "transition", 
      "addition", 
      "frequency", 
      "frequency 50", 
      "conditional mutator", 
      "mutation frequencies 50", 
      "rich medium mutation frequencies", 
      "medium mutation frequencies", 
      "possible base-pair mutations", 
      "aud G", 
      "trpA frameshift mutations", 
      "conditional Escherichia coli mutator", 
      "coli mutator"
    ], 
    "name": "Mutational specificity of a conditional Escherichia coli mutator, mutD5", 
    "pagination": "179-191", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1013207360"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00267667"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "4614067"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00267667", 
      "https://app.dimensions.ai/details/publication/pub.1013207360"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_132.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf00267667"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00267667'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00267667'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00267667'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00267667'


 

This table displays all metadata directly associated to this object as RDF triples.

148 TRIPLES      21 PREDICATES      70 URIs      60 LITERALS      13 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00267667 schema:about N0d167fce86b348d1ad9a2451c0793513
2 N359a061b5c5e48b7ad8a05848b5eb2a0
3 N3a3fd812c4c743c9950226d0112b5173
4 N95b8616aea1b4c73add850d4d738750d
5 Nb05fa40f895d4156a86f4839f3b67748
6 Ndd57ac7c6fe8454fa046b524409fbc74
7 anzsrc-for:06
8 anzsrc-for:0604
9 schema:author N55fabd111342418d8b740dc2a0534632
10 schema:citation sg:pub.10.1007/bf00267054
11 sg:pub.10.1038/newbio236019a0
12 schema:datePublished 1974-09
13 schema:datePublishedReg 1974-09-01
14 schema:description MutD5, a conditional mutator in Escherichia coli, causes the stimulation of mutation frequencies 50 to 100 fold in minimal medium. In rich medium mutation frequencies are further increased 50 to 100 fold. We show here that all possible base-pair mutations are increased in a mutD5 strain grown in rich medium. A:T↔G:C transitions as well as A:T↔C:G, A:T↔T:A aud G:C↔C:G transversions are stimulated. Transitions occur more frequently than transversions. MutD5 also increases the reversion frequencies of three trpA frameshift mutations by causing base-pair additions, and, possibly, base-pair deletions.
15 schema:genre article
16 schema:isAccessibleForFree false
17 schema:isPartOf N1bbeea4c46664bb2aeeefde475567fa4
18 N97374b5a12254c2cb89bb2cb95acaf11
19 sg:journal.1297380
20 schema:keywords Escherichia coli
21 Escherichia coli mutator
22 addition
23 aud G
24 base pair addition
25 base pair deletion
26 base pair mutation
27 coli
28 coli mutator
29 conditional Escherichia coli mutator
30 conditional mutator
31 deletion
32 folds
33 frameshift mutation
34 frequency
35 frequency 50
36 medium
37 medium mutation frequencies
38 minimal medium
39 mutD5
40 mutD5 strain
41 mutation frequencies 50
42 mutation frequency
43 mutational specificity
44 mutations
45 mutator
46 possible base-pair mutations
47 reversion frequency
48 rich medium
49 rich medium mutation frequencies
50 specificity
51 stimulation
52 strains
53 transition
54 transversions
55 trpA frameshift mutations
56 schema:name Mutational specificity of a conditional Escherichia coli mutator, mutD5
57 schema:pagination 179-191
58 schema:productId N2f0ada7222a54eeaa608a8ad473df29b
59 N7579d70f677d421d80cc3e50234b4901
60 Naf8441fda6854535b012146e9184dbc3
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013207360
62 https://doi.org/10.1007/bf00267667
63 schema:sdDatePublished 2022-01-01T18:01
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher N02368f7a53c54771b521c47d35954ec3
66 schema:url https://doi.org/10.1007/bf00267667
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N02368f7a53c54771b521c47d35954ec3 schema:name Springer Nature - SN SciGraph project
71 rdf:type schema:Organization
72 N0d167fce86b348d1ad9a2451c0793513 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Genetics, Microbial
74 rdf:type schema:DefinedTerm
75 N1bbeea4c46664bb2aeeefde475567fa4 schema:volumeNumber 133
76 rdf:type schema:PublicationVolume
77 N2ee2c049eda24e30b6e68bb9ecbd96f0 rdf:first sg:person.0113476226.74
78 rdf:rest Nf6a4c99686be41aca0947e7012f51472
79 N2f0ada7222a54eeaa608a8ad473df29b schema:name doi
80 schema:value 10.1007/bf00267667
81 rdf:type schema:PropertyValue
82 N359a061b5c5e48b7ad8a05848b5eb2a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Escherichia coli
84 rdf:type schema:DefinedTerm
85 N3a3fd812c4c743c9950226d0112b5173 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Species Specificity
87 rdf:type schema:DefinedTerm
88 N55fabd111342418d8b740dc2a0534632 rdf:first N6ea8f26161414a4991d41fdc60c1fb4d
89 rdf:rest N2ee2c049eda24e30b6e68bb9ecbd96f0
90 N6ea8f26161414a4991d41fdc60c1fb4d schema:affiliation grid-institutes:grid.16750.35
91 schema:familyName Fowler
92 schema:givenName Robert G.
93 rdf:type schema:Person
94 N7579d70f677d421d80cc3e50234b4901 schema:name dimensions_id
95 schema:value pub.1013207360
96 rdf:type schema:PropertyValue
97 N95b8616aea1b4c73add850d4d738750d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Chromosome Aberrations
99 rdf:type schema:DefinedTerm
100 N97374b5a12254c2cb89bb2cb95acaf11 schema:issueNumber 3
101 rdf:type schema:PublicationIssue
102 Naf8441fda6854535b012146e9184dbc3 schema:name pubmed_id
103 schema:value 4614067
104 rdf:type schema:PropertyValue
105 Nb05fa40f895d4156a86f4839f3b67748 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Chromosome Mapping
107 rdf:type schema:DefinedTerm
108 Ndd57ac7c6fe8454fa046b524409fbc74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Mutation
110 rdf:type schema:DefinedTerm
111 Nf6a4c99686be41aca0947e7012f51472 rdf:first sg:person.01224726520.36
112 rdf:rest rdf:nil
113 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
114 schema:name Biological Sciences
115 rdf:type schema:DefinedTerm
116 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
117 schema:name Genetics
118 rdf:type schema:DefinedTerm
119 sg:journal.1297380 schema:issn 1432-1874
120 1617-4615
121 schema:name Molecular Genetics and Genomics
122 schema:publisher Springer Nature
123 rdf:type schema:Periodical
124 sg:person.0113476226.74 schema:affiliation grid-institutes:grid.47100.32
125 schema:familyName Degnen
126 schema:givenName Gerald E.
127 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0113476226.74
128 rdf:type schema:Person
129 sg:person.01224726520.36 schema:affiliation grid-institutes:grid.16750.35
130 schema:familyName Cox
131 schema:givenName Edward C.
132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224726520.36
133 rdf:type schema:Person
134 sg:pub.10.1007/bf00267054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019362511
135 https://doi.org/10.1007/bf00267054
136 rdf:type schema:CreativeWork
137 sg:pub.10.1038/newbio236019a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029463330
138 https://doi.org/10.1038/newbio236019a0
139 rdf:type schema:CreativeWork
140 grid-institutes:grid.16750.35 schema:alternateName Department of Biochemical Sciences, Princeton University, Princeton, N. J., USA
141 schema:name Department of Biochemical Sciences, Princeton University, Princeton, N. J., USA
142 Department of Biology, Princeton University, Princeton, N. J., USA
143 rdf:type schema:Organization
144 grid-institutes:grid.47100.32 schema:alternateName Department of Human Genetics, Yale University, 06510, New Haven, Conn., USA
145 schema:name Department of Biochemical Sciences, Princeton University, Princeton, N. J., USA
146 Department of Biology, Princeton University, Princeton, N. J., USA
147 Department of Human Genetics, Yale University, 06510, New Haven, Conn., USA
148 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...