Requirement of DNA Gyrase for the initiation of chromosome replication in Escherichia coli K-12 View Full Text


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Article Info

DATE

1980-01

AUTHORS

Marcin Filutowicz

ABSTRACT

It has been found that strains carrying mutations in the dnaA gene are unusually sensitive to COU, NAL or NOV, which are known to inhibit DNA gyrase activities. The delay in the initiation of chromosome replication after COU treatment has been observed in cells with chromosomes synchronized by amino acid starvation or by temperature shift-up (dnaA46). The unusual sensitivity of growth to COU of the initiation mutant runs parallel to a higher sensitivity to the drug of the initiation of chromosome replication.The double mutant, dnaA46 cou-110 has been isolated and mutation cou-110 conferring resistance of growth, initiation and elongation of chromosome replication to COU was mapped in the gene coding for the subunit of DNA gyrase. The reduced frequency of appearance of the mutants resistant to COU, NAL or NOV in the initiation mutant suggests that some mutations in genes coding for DNA gyrase subunits cannot coexist with the dnaA46 mutation. The possible mechanisms of the requirement of DNA gyrase for dnaA-dependent initiation of E. coli chromosome are discussed. More... »

PAGES

301-309

References to SciGraph publications

  • 1978. Genetic and Physiological Properties of an Escherichia Coli Strain Carrying the dnaA Mutation T46 in DNA SYNTHESIS
  • 1972-06. Impaired DNA synthesis and envelope defect in a mutant ofSalmonella typhimurium in MOLECULAR GENETICS AND GENOMICS
  • 1978-01. Lambda transducing phages for the nalA gene of Escherichia coli and conditional lethal nalA mutations in MOLECULAR GENETICS AND GENOMICS
  • 1977-11. Involvement of DNA gyrase in bacteriophage T7 DNA replication in NATURE
  • 1971-08. Evidence for the Bidirectional Replication of the Escherichia coli Chromosome in NATURE
  • 1978-01. An unusual interaction between the target of nalidixic acid and novobiocin in NATURE
  • 1979-01. Control of the initiation of DNA replication in Escherichia coli in MOLECULAR GENETICS AND GENOMICS
  • 1979-01. Control of the initiation of DNA replication in Escherichia coli in MOLECULAR GENETICS AND GENOMICS
  • 1978. The Function of RNA Polymerase and dnaA in the Intitiation of Chromosome Replication in Escherichia coli and Salmonella Typhimurium in DNA SYNTHESIS
  • 1977-01. Origin of replication, oriC, of the Escherichia coli chromosome: Mapping of genes relative to R.EcoRI cleavage sites in the oriC region in MOLECULAR GENETICS AND GENOMICS
  • 1974-03. Initiation of DNA replication in Escherichia coli in MOLECULAR GENETICS AND GENOMICS
  • 1978-10. Promoter-specific inhibition of transcription by antibiotics which act on DNA gyrase in NATURE
  • 1970-06. Escherichia coli mutants with temperature-sensitive synthesis of DNA in MOLECULAR GENETICS AND GENOMICS
  • 1977-02. Nucleotide sequence of bacteriophage φX174 DNA in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00267443

    DOI

    http://dx.doi.org/10.1007/bf00267443

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041729923

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6245341


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