Acute effects of nicotinic acid on hepatic transport of 99mTc-PIPIDA View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-01

AUTHORS

Rex B. Shafer, Robert G. Knodell, Laura N. Stanley, Michael K. Elson

ABSTRACT

Hepatic injury has been associated with nicotinic acid treatment of schizophrenia and hypercholesterolemia. This association was implicated when the liver and biliary tract were not visualized after 99mTc-HIDA in a patient taking 3 g daily of nicotinic acid. We studied hepatic transport of 99mTc-PIPIDA both in vitro in isolated hepatocytes and in vivo in rabbits pretreated with nicotinic acid to further examine this association. Nicotinic acid increased uptake of PIPIDA by isolated hepatocytes and 7 days of nicotinic acid treatment in rabbits produced no abnormalities in hepatic uptake, gallbladder visualization, or biliary excretion of PIPIDA. We conclude that nicotinic acid does not have an inhibitory effect on uptake of biliary imaging agents and actually may be useful in enhancing hepatic imaging in patients with reduced liver function. More... »

PAGES

12-14

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00263507

DOI

http://dx.doi.org/10.1007/bf00263507

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047731811

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6832182


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