High-dose methotrexate: Preliminary evaluation of a pharmacokinetic approach View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1979-11

AUTHORS

S. Monjanel, J. P. Rigault, J. P. Cano, Y. Carcassonne, R. Favre

ABSTRACT

Clinical pharmacologic studies have been carried out in patients with head and neck tumors following 36-h continuous infusions of high-dose MTX (1.5 g/m2). The results indicated considerable variation in the amount of MTX in the blood of individual patients. To control these variations, a modified protocol was set up to try to attain the same MTX blood level in all subjects. The protocol has a pharmacokinetic basis and involves determination of the MTX kinetics in each patient. The information thus obtained allows us to compute a 36-h infusion dose so that the MTX plasma levels never exceed a threshold beyond which there is a risk of toxicity to the host. The computation is validated by taking a blood sample 6 h after the beginning of the infusion. If the MTX concentration is higher than its expected value, the infusion rate can then be immediately reduced. Analytical methods that will allow such a computation, the results of the clinical application of this pharmacokinetic approach, and some implications of such a method are discussed. More... »

PAGES

189-196

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00262421

DOI

http://dx.doi.org/10.1007/bf00262421

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003952452

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/527209


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