The pancreas in recent-onset Type 1 (insulin-dependent) diabetes mellitus: insulin content of islets, insulitis and associated changes in the exocrine ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1984-06

AUTHORS

A. K. Foulis, J. A. Stewart

ABSTRACT

The pancreatic autopsy findings of 11 children with Type 1 (insulin-dependent) diabetes mellitus are presented. Nine children died within 24 h of initial presentation. In these 'recent-onset' diabetic patients many islets were shrunken and insulin-deficient. However, large islets containing B cells were present also. Insulitis was present in eight recent-onset diabetic subjects; in these, 18% of insulin-containing islets were inflamed, but only 1% of insulin-deficient islets were thus affected. This finding supports the concept of an immunologically mediated destruction of B cells in the pathogenesis of Type 1 diabetes. Severe acinar cell atrophy was present surrounding insulin-deficient islets, but acinar tissue around insulin-containing islets was normal. These exocrine changes are thought to be related to islet-exocrine vascular connections and the effects of the various islet hormones on pancreatic acini. More... »

PAGES

456-461

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00262221

DOI

http://dx.doi.org/10.1007/bf00262221

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008216941

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6381192


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