Comparative antitumor activity of ruthenium derivatives with 5′-deoxy-5-fluorouridine in chemically induced colorectal tumors in SD rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-07

AUTHORS

F. T. Garzon, M. R. Berger, B. K. Keppler, D. Schmähl

ABSTRACT

The activity of the newly synthesized ruthenium derivative imidazolium-bis(imidazole)tetrachlororuthenate (III) [ImH(RuIm2Cl4)] was compared with that of 5′-deoxy-5-fluorouridine (5′dFUR) in autochthonous acetoxymethyl-methylnitrosamine (AMMN)-induced colorectal cancer in SD rats. Following coloscopic diagnosis of colorectal tumors treatment was administered twice weekly for a 10-week period. ImH(RuIm2Cl4) exhibited considerable antitumoral efficacy compared with 5′dFUR (20 T/C % and 60 T/C %, respectively) against the growth of AMMN-induced colorectal adenocarcinoma in SD rats. The mortality rates with ImH(RuIm2Cl4) were dose-related, but its efficacy did not vary in all doses administered. More... »

PAGES

347-349

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00261487

DOI

http://dx.doi.org/10.1007/bf00261487

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020513223

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2954714


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185 schema:name Institute of Inorganic Chemistry, Heidelberg University, Im Neuenheimer Feld 270, D-6900, Heidelberg, Federal Republic of Germany
186 rdf:type schema:Organization
 




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