FemA, a host-mediated factor essential for methicillin resistance in Staphylococcus aureus: Molecular cloning and characterization View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1989-10

AUTHORS

Brigitte Berger-Bächi, Luisella Barberis-Maino, Anni Strässle, Fritz H. Kayser

ABSTRACT

The methicillin resistance determinant (mec) in Staphylococcus aureus resides on additional DNA not present in isogenic sensitive cells. However, besides mec, other chromosomally determined factors are essential for expression of methicillin resistance. We cloned and characterized a chromosomally determined gene which encodes a factor essential for the expression of methicillin resistance (femA) in S. aureus. femA mapped in chromosomal segment number 18, genetically very distant from the methicillin resistance determinant (mec). The product of femA was a protein of an apparent size of 48 kDa. FemA restored methicillin resistance in S. aureus that had become sensitive to methicillin by insertion of Ω22003 (femA::Tn551). Although FemA was needed for cell growth in the presence of β-lactam antibiotics, it had no influence on the synthesis of the low affinity, additional penicillin-binding protein (PBP2′) encoded by mec and known to be essential for cell wall synthesis in the presence of inhibitory concentrations of methicillin. Nucleotide sequence analysis, Northern RNA blotting and S1 nuclease RNA mapping suggested that femA was transcribed on a polycistronic mRNA. This mRNA contained the coding region for FemA (ORF433) and a second coding region (ORF419) producing a protein of 47 kDa. The nucleotide and amino acid sequence of FemA showed homologies with ORF419, suggesting that these genes arose by gene duplication. In addition we present evidence for a second chromosomal factor, femB, involved in expression of methicillin resistance which maps close to femA. More... »

PAGES

263-269

References to SciGraph publications

Journal

TITLE

Molecular Genetics and Genomics

ISSUE

1-2

VOLUME

219

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00261186

DOI

http://dx.doi.org/10.1007/bf00261186

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011888879

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2559314


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