Decreased plasma half-life of cyclophosphamide during repeated high-dose administration View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-06

AUTHORS

M. I. Graham, I. C. Shaw, R. L. Souhami, B. Sidau, P. G. Harper, A. E. M. McLean

ABSTRACT

Cyclophosphamide was given as IV doses of 50 mg/kg/day on each of four successive days as treatment for ovarian and lung cancer. Blood samples were taken at regular intervals and analysed for cyclophosphamide by gas liquid chromatography. The plasma half-lives (t 1/2) and volumes of distribution (V D) were calculated for each of the treatment days; t 1/2 was found to decrease with subsequent doses whereas V D was not significantly changed. More... »

PAGES

192-193

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00255760

DOI

http://dx.doi.org/10.1007/bf00255760

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007615855

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6861264


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclophosphamide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Half-Life", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kinetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovarian Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Laboratory of Toxicology and Pharmacokinetics, Dept. of Clinical Pharmacology, University College London, 5, University Street, WC1, London"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Graham", 
        "givenName": "M. I.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Laboratory of Toxicology and Pharmacokinetics, Dept. of Clinical Pharmacology, University College London, 5, University Street, WC1, London"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shaw", 
        "givenName": "I. C.", 
        "id": "sg:person.0604631373.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604631373.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College Hospital", 
          "id": "https://www.grid.ac/institutes/grid.439749.4", 
          "name": [
            "Department of Radiotherapy and Oncology, University College Hospital, Gower Street, WC1, London, England"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Souhami", 
        "givenName": "R. L.", 
        "id": "sg:person.0736072270.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736072270.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Laboratory of Toxicology and Pharmacokinetics, Dept. of Clinical Pharmacology, University College London, 5, University Street, WC1, London"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sidau", 
        "givenName": "B.", 
        "id": "sg:person.0100304727.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0100304727.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College Hospital", 
          "id": "https://www.grid.ac/institutes/grid.439749.4", 
          "name": [
            "Department of Radiotherapy and Oncology, University College Hospital, Gower Street, WC1, London, England"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harper", 
        "givenName": "P. G.", 
        "id": "sg:person.01025232030.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025232030.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Laboratory of Toxicology and Pharmacokinetics, Dept. of Clinical Pharmacology, University College London, 5, University Street, WC1, London"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McLean", 
        "givenName": "A. E. M.", 
        "id": "sg:person.016370612702.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016370612702.62"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1476-5381.1971.tb07199.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013057433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jps.2600631014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016058554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(78)91369-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033879689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00292868", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049703229", 
          "https://doi.org/10.1007/bf00292868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2964(79)90198-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050641219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074693732", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080530459", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081617243", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1983-06", 
    "datePublishedReg": "1983-06-01", 
    "description": "Cyclophosphamide was given as IV doses of 50 mg/kg/day on each of four successive days as treatment for ovarian and lung cancer. Blood samples were taken at regular intervals and analysed for cyclophosphamide by gas liquid chromatography. The plasma half-lives (t 1/2) and volumes of distribution (V D) were calculated for each of the treatment days; t 1/2 was found to decrease with subsequent doses whereas V D was not significantly changed.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00255760", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1088364", 
        "issn": [
          "0344-5704", 
          "1432-0843"
        ], 
        "name": "Cancer Chemotherapy and Pharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Decreased plasma half-life of cyclophosphamide during repeated high-dose administration", 
    "pagination": "192-193", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2446c0b339580a941e23d9c2172dc3c56d3d6b9114accd30ed4e37af3de37a48"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "6861264"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7806519"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00255760"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1007615855"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00255760", 
      "https://app.dimensions.ai/details/publication/pub.1007615855"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130814_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF00255760"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00255760'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00255760'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00255760'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00255760'


 

This table displays all metadata directly associated to this object as RDF triples.

164 TRIPLES      21 PREDICATES      46 URIs      30 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00255760 schema:about N19cc369c0f604c65aecf82fe0e9b7859
2 N2813203368c04b14a1b57b3fa0f8bff1
3 N6d48dd8101124ccab1e4b290f9b2d063
4 N7300978cfd824371bfc1691c9f20cf09
5 N97994150a2114bc4be4dd80b81ec083c
6 Nac247d9d62534a4ba61671e09ad586ae
7 Ned1cb8535af64de68a478ca7964f23af
8 Nee7d04417d76400fbd5f6b87a959ad39
9 Nfa8ad569ab5f4278b388c07accb55ca3
10 anzsrc-for:11
11 anzsrc-for:1112
12 schema:author N5a4ba6c3eede4ec1be33efd74b709f7f
13 schema:citation sg:pub.10.1007/bf00292868
14 https://app.dimensions.ai/details/publication/pub.1074693732
15 https://app.dimensions.ai/details/publication/pub.1080530459
16 https://app.dimensions.ai/details/publication/pub.1081617243
17 https://doi.org/10.1002/jps.2600631014
18 https://doi.org/10.1016/0006-291x(78)91369-4
19 https://doi.org/10.1016/0014-2964(79)90198-1
20 https://doi.org/10.1111/j.1476-5381.1971.tb07199.x
21 schema:datePublished 1983-06
22 schema:datePublishedReg 1983-06-01
23 schema:description Cyclophosphamide was given as IV doses of 50 mg/kg/day on each of four successive days as treatment for ovarian and lung cancer. Blood samples were taken at regular intervals and analysed for cyclophosphamide by gas liquid chromatography. The plasma half-lives (t 1/2) and volumes of distribution (V D) were calculated for each of the treatment days; t 1/2 was found to decrease with subsequent doses whereas V D was not significantly changed.
24 schema:genre research_article
25 schema:inLanguage en
26 schema:isAccessibleForFree false
27 schema:isPartOf N7879f3ebc81b4c908a4ee4e44a142c99
28 N95cff8a808af4a41ad55a2dfbc7d9ee6
29 sg:journal.1088364
30 schema:name Decreased plasma half-life of cyclophosphamide during repeated high-dose administration
31 schema:pagination 192-193
32 schema:productId N1e29bbead67049ca8fa7b4a9ebdb1c9f
33 N238cf9032260473691ac42ce261fbb7f
34 N79288f5044764964ae9337d4a3bbb342
35 Nc5fba74f11324b12b0a72cd0f7e566fc
36 Ndc5fbf538b14411db8e9beb76083fce0
37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007615855
38 https://doi.org/10.1007/bf00255760
39 schema:sdDatePublished 2019-04-11T13:55
40 schema:sdLicense https://scigraph.springernature.com/explorer/license/
41 schema:sdPublisher N44ae694d011b4725980746595a914016
42 schema:url http://link.springer.com/10.1007/BF00255760
43 sgo:license sg:explorer/license/
44 sgo:sdDataset articles
45 rdf:type schema:ScholarlyArticle
46 N03851ddbe45243d6b23f996e066ee631 rdf:first sg:person.016370612702.62
47 rdf:rest rdf:nil
48 N19cc369c0f604c65aecf82fe0e9b7859 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
49 schema:name Half-Life
50 rdf:type schema:DefinedTerm
51 N1e29bbead67049ca8fa7b4a9ebdb1c9f schema:name nlm_unique_id
52 schema:value 7806519
53 rdf:type schema:PropertyValue
54 N238cf9032260473691ac42ce261fbb7f schema:name pubmed_id
55 schema:value 6861264
56 rdf:type schema:PropertyValue
57 N2440aea62f4441e288c281a087a0bb1d rdf:first sg:person.0100304727.87
58 rdf:rest N52902b2dab3a4a3795a548bad20e6bd5
59 N2813203368c04b14a1b57b3fa0f8bff1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
60 schema:name Ovarian Neoplasms
61 rdf:type schema:DefinedTerm
62 N44ae694d011b4725980746595a914016 schema:name Springer Nature - SN SciGraph project
63 rdf:type schema:Organization
64 N52902b2dab3a4a3795a548bad20e6bd5 rdf:first sg:person.01025232030.85
65 rdf:rest N03851ddbe45243d6b23f996e066ee631
66 N5a4ba6c3eede4ec1be33efd74b709f7f rdf:first Ne5362ab2c18648eb8d1c486ecfb8bd6d
67 rdf:rest N5ab896df1106469e97a82a72486d1cbd
68 N5ab896df1106469e97a82a72486d1cbd rdf:first sg:person.0604631373.01
69 rdf:rest Nf2f7c0f684f6488db93b33364555ff9b
70 N6d48dd8101124ccab1e4b290f9b2d063 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Male
72 rdf:type schema:DefinedTerm
73 N7300978cfd824371bfc1691c9f20cf09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Cyclophosphamide
75 rdf:type schema:DefinedTerm
76 N7879f3ebc81b4c908a4ee4e44a142c99 schema:issueNumber 3
77 rdf:type schema:PublicationIssue
78 N79288f5044764964ae9337d4a3bbb342 schema:name dimensions_id
79 schema:value pub.1007615855
80 rdf:type schema:PropertyValue
81 N95cff8a808af4a41ad55a2dfbc7d9ee6 schema:volumeNumber 10
82 rdf:type schema:PublicationVolume
83 N97994150a2114bc4be4dd80b81ec083c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Lung Neoplasms
85 rdf:type schema:DefinedTerm
86 Nac247d9d62534a4ba61671e09ad586ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Humans
88 rdf:type schema:DefinedTerm
89 Nc5fba74f11324b12b0a72cd0f7e566fc schema:name doi
90 schema:value 10.1007/bf00255760
91 rdf:type schema:PropertyValue
92 Ndc5fbf538b14411db8e9beb76083fce0 schema:name readcube_id
93 schema:value 2446c0b339580a941e23d9c2172dc3c56d3d6b9114accd30ed4e37af3de37a48
94 rdf:type schema:PropertyValue
95 Ne5362ab2c18648eb8d1c486ecfb8bd6d schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
96 schema:familyName Graham
97 schema:givenName M. I.
98 rdf:type schema:Person
99 Ned1cb8535af64de68a478ca7964f23af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Kinetics
101 rdf:type schema:DefinedTerm
102 Nee7d04417d76400fbd5f6b87a959ad39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Female
104 rdf:type schema:DefinedTerm
105 Nf2f7c0f684f6488db93b33364555ff9b rdf:first sg:person.0736072270.46
106 rdf:rest N2440aea62f4441e288c281a087a0bb1d
107 Nfa8ad569ab5f4278b388c07accb55ca3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Dose-Response Relationship, Drug
109 rdf:type schema:DefinedTerm
110 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
111 schema:name Medical and Health Sciences
112 rdf:type schema:DefinedTerm
113 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
114 schema:name Oncology and Carcinogenesis
115 rdf:type schema:DefinedTerm
116 sg:journal.1088364 schema:issn 0344-5704
117 1432-0843
118 schema:name Cancer Chemotherapy and Pharmacology
119 rdf:type schema:Periodical
120 sg:person.0100304727.87 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
121 schema:familyName Sidau
122 schema:givenName B.
123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0100304727.87
124 rdf:type schema:Person
125 sg:person.01025232030.85 schema:affiliation https://www.grid.ac/institutes/grid.439749.4
126 schema:familyName Harper
127 schema:givenName P. G.
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025232030.85
129 rdf:type schema:Person
130 sg:person.016370612702.62 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
131 schema:familyName McLean
132 schema:givenName A. E. M.
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016370612702.62
134 rdf:type schema:Person
135 sg:person.0604631373.01 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
136 schema:familyName Shaw
137 schema:givenName I. C.
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604631373.01
139 rdf:type schema:Person
140 sg:person.0736072270.46 schema:affiliation https://www.grid.ac/institutes/grid.439749.4
141 schema:familyName Souhami
142 schema:givenName R. L.
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736072270.46
144 rdf:type schema:Person
145 sg:pub.10.1007/bf00292868 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049703229
146 https://doi.org/10.1007/bf00292868
147 rdf:type schema:CreativeWork
148 https://app.dimensions.ai/details/publication/pub.1074693732 schema:CreativeWork
149 https://app.dimensions.ai/details/publication/pub.1080530459 schema:CreativeWork
150 https://app.dimensions.ai/details/publication/pub.1081617243 schema:CreativeWork
151 https://doi.org/10.1002/jps.2600631014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016058554
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1016/0006-291x(78)91369-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033879689
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1016/0014-2964(79)90198-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050641219
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1111/j.1476-5381.1971.tb07199.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013057433
158 rdf:type schema:CreativeWork
159 https://www.grid.ac/institutes/grid.439749.4 schema:alternateName University College Hospital
160 schema:name Department of Radiotherapy and Oncology, University College Hospital, Gower Street, WC1, London, England
161 rdf:type schema:Organization
162 https://www.grid.ac/institutes/grid.83440.3b schema:alternateName University College London
163 schema:name Laboratory of Toxicology and Pharmacokinetics, Dept. of Clinical Pharmacology, University College London, 5, University Street, WC1, London
164 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...