PET measurement of D2 and S2 receptor binding of 3-N-([2′-18F]fluoroethyl)spiperone in baboon brain View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-05

AUTHORS

Heinz H. Coenen, Klaus Wienhard, Gerhard Stöcklin, Peter Laufer, Ira Hebold, Günter Pawlik, Wolf-Dieter Heiss

ABSTRACT

The regional pharmacokinetic behavior in baboon brain of 18F-fluoroethyl- and 18F-fluoropropylspiperone (18FESP, 18FPSP) at specific activities greater than or equal to 1000 Ci/mmol was studied with PET. Four hours after injection of 5-10 mCi 18FESP, uptake in striatum was 0.048% +/- 0.005% of injected dose per cm3, which is almost the same as with 18F- and 11C-methylspiperone. While 18FPSP was taken up in much smaller amounts than 18FESP, striatum to cerebellum activity ratios were quite similar for both ligands (about 9 to 10 at 4 h p.i.). Because of its higher striatal uptake, 18FESP seems to be better suited for PET. Furthermore, relative binding to S2 receptors was much smaller for FESP: competing cold S2 antagonists (ritanserin, ketanserin) did not alter 18FESP binding to striatum, concurrently reducing uptake in frontal cortex by only 15%-20%. With coinjection of increasing amounts of cold FESP, saturation of 18FESP binding to striatum occurred at doses exceeding 10 micrograms per kg. Quantitative analysis of radiolabelled ligand in arterial plasma (decrease to 8% at 4 h p.i.) demonstrated identical metabolic turnover for both ligands. Direct use of binding fractions from the saturation curve resulted in overestimation of the receptor density in striatum. Using the 18FESP plasma concentration time curve and the dynamic uptake data, k3 of a three compartment model could be determined by non linear regression. However, dramatic changes of the dependence of k3 on the specifically bound ligand concentration were observed even at small loading doses of FESP. Estimation of Bmax yielded a D2 receptor density of only 6 pmol per cm3 in baboon striatum. More... »

PAGES

80-87

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00253446

DOI

http://dx.doi.org/10.1007/bf00253446

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012549766

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2968911


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0299", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Other Physical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/02", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Physical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebellum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Corpus Striatum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorine Radioisotopes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Papio", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Dopamine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Dopamine D2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Serotonin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spiperone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tomography, Emission-Computed", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Institut f\u00fcr Chemie 1 (Nuklearchemie) der Kernforschungsanlage J\u00fclich GmbH, D-5170, J\u00fclich, Federal Republic of Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coenen", 
        "givenName": "Heinz H.", 
        "id": "sg:person.01342401277.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342401277.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Metabolism Research", 
          "id": "https://www.grid.ac/institutes/grid.418034.a", 
          "name": [
            "Max-Planck-Institut f\u00fcr Neurologische Forschung, D-5000, K\u00f6ln 30, Federal Republic of Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wienhard", 
        "givenName": "Klaus", 
        "id": "sg:person.0747547562.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747547562.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institut f\u00fcr Chemie 1 (Nuklearchemie) der Kernforschungsanlage J\u00fclich GmbH, D-5170, J\u00fclich, Federal Republic of Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "St\u00f6cklin", 
        "givenName": "Gerhard", 
        "id": "sg:person.01324373457.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324373457.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institut f\u00fcr Chemie 1 (Nuklearchemie) der Kernforschungsanlage J\u00fclich GmbH, D-5170, J\u00fclich, Federal Republic of Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Laufer", 
        "givenName": "Peter", 
        "id": "sg:person.01256260257.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256260257.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Metabolism Research", 
          "id": "https://www.grid.ac/institutes/grid.418034.a", 
          "name": [
            "Max-Planck-Institut f\u00fcr Neurologische Forschung, D-5000, K\u00f6ln 30, Federal Republic of Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hebold", 
        "givenName": "Ira", 
        "id": "sg:person.010027141254.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010027141254.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Metabolism Research", 
          "id": "https://www.grid.ac/institutes/grid.418034.a", 
          "name": [
            "Max-Planck-Institut f\u00fcr Neurologische Forschung, D-5000, K\u00f6ln 30, Federal Republic of Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pawlik", 
        "givenName": "G\u00fcnter", 
        "id": "sg:person.015044471104.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015044471104.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Metabolism Research", 
          "id": "https://www.grid.ac/institutes/grid.418034.a", 
          "name": [
            "Max-Planck-Institut f\u00fcr Neurologische Forschung, D-5000, K\u00f6ln 30, Federal Republic of Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heiss", 
        "givenName": "Wolf-Dieter", 
        "id": "sg:person.014142346732.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014142346732.64"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1038/jcbfm.1986.26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001791964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1986.26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001791964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(87)90255-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002177021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(87)90255-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002177021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0883-2889(86)90139-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003587147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0883-2889(86)90139-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003587147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(82)90599-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008571668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(82)90599-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008571668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1988.tb01830.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010581358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0883-2897(86)90134-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011557895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0883-2897(86)90035-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012333849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0047-0740(85)80003-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012375640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(84)90391-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014293857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(84)90391-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014293857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(86)90652-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021716825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(86)90652-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021716825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1986.96", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021721941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1986.96", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021721941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004728-198501000-00024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023280889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004728-198501000-00024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023280889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1985.tb12891.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023390610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00256924", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024770401", 
          "https://doi.org/10.1007/bf00256924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00256924", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024770401", 
          "https://doi.org/10.1007/bf00256924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(80)90073-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027537322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(80)90073-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027537322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(77)90855-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028436894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(77)90855-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028436894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jlcr.2580250211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031792846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(78)90538-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032538949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(78)90538-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032538949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0160-5402(87)90048-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034096003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(85)90041-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034830571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(85)90041-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034830571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0883-2889(86)90003-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035077263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0883-2889(86)90003-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035077263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0883-2897(86)90132-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035085421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jlcr.2580240108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037077754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(81)90562-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040259684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(81)90562-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040259684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(83)90725-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041929739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(83)90725-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041929739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(78)90044-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042247442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(78)90044-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042247442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(83)90729-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043649336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(83)90729-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043649336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.ph.43.030181.001323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045475939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0883-2889(86)90002-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046384445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0883-2889(86)90002-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046384445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.78.4.2620", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050366261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2878495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062568977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.6334363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062636824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.6604315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062639159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079428156", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079429305", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081911162", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1988-05", 
    "datePublishedReg": "1988-05-01", 
    "description": "The regional pharmacokinetic behavior in baboon brain of 18F-fluoroethyl- and 18F-fluoropropylspiperone (18FESP, 18FPSP) at specific activities greater than or equal to 1000 Ci/mmol was studied with PET. Four hours after injection of 5-10 mCi 18FESP, uptake in striatum was 0.048% +/- 0.005% of injected dose per cm3, which is almost the same as with 18F- and 11C-methylspiperone. While 18FPSP was taken up in much smaller amounts than 18FESP, striatum to cerebellum activity ratios were quite similar for both ligands (about 9 to 10 at 4 h p.i.). Because of its higher striatal uptake, 18FESP seems to be better suited for PET. Furthermore, relative binding to S2 receptors was much smaller for FESP: competing cold S2 antagonists (ritanserin, ketanserin) did not alter 18FESP binding to striatum, concurrently reducing uptake in frontal cortex by only 15%-20%. With coinjection of increasing amounts of cold FESP, saturation of 18FESP binding to striatum occurred at doses exceeding 10 micrograms per kg. Quantitative analysis of radiolabelled ligand in arterial plasma (decrease to 8% at 4 h p.i.) demonstrated identical metabolic turnover for both ligands. Direct use of binding fractions from the saturation curve resulted in overestimation of the receptor density in striatum. Using the 18FESP plasma concentration time curve and the dynamic uptake data, k3 of a three compartment model could be determined by non linear regression. However, dramatic changes of the dependence of k3 on the specifically bound ligand concentration were observed even at small loading doses of FESP. Estimation of Bmax yielded a D2 receptor density of only 6 pmol per cm3 in baboon striatum.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00253446", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1297401", 
        "issn": [
          "1619-7070", 
          "1619-7089"
        ], 
        "name": "European Journal of Nuclear Medicine and Molecular Imaging", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "PET measurement of D2 and S2 receptor binding of 3-N-([2\u2032-18F]fluoroethyl)spiperone in baboon brain", 
    "pagination": "80-87", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3bca2f6390ef8b9efe8726fdfcd2e2b426d6b5ab020f89f6535bc97ceff2546e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2968911"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7606882"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00253446"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012549766"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00253446", 
      "https://app.dimensions.ai/details/publication/pub.1012549766"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:02", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130831_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF00253446"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00253446'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00253446'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00253446'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00253446'


 

This table displays all metadata directly associated to this object as RDF triples.

271 TRIPLES      21 PREDICATES      77 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00253446 schema:about N0ad5d66494af404db2c0a07d888746e2
2 N2d5f121954cf41f6a2a5ad0424213296
3 N3deb7a97871144ccadd29b02c348bb93
4 N3f59049e4d174c399d51e8cf896fe3d3
5 N43db6dc89c664d81845779e07aaf1984
6 N536672facbfd4722bc94ff2b73c7635a
7 N5ce1b20461e844b7bb3b43daab9f3ec7
8 Na0c180ff56de460484da6bd07964c36a
9 Nb823b4a9e5bd4aca834d23fb183ea5a2
10 Ncad74c27ddf048159e08bb4945c2333a
11 Nd7d17cf72ea346fdb4e2346d83262401
12 Nd95a0c4fdba4414c81274758fa02c157
13 anzsrc-for:02
14 anzsrc-for:0299
15 schema:author Nedd7f0522c81406d9598a3033f32ee62
16 schema:citation sg:pub.10.1007/bf00256924
17 https://app.dimensions.ai/details/publication/pub.1079428156
18 https://app.dimensions.ai/details/publication/pub.1079429305
19 https://app.dimensions.ai/details/publication/pub.1081911162
20 https://doi.org/10.1002/jlcr.2580240108
21 https://doi.org/10.1002/jlcr.2580250211
22 https://doi.org/10.1016/0006-8993(77)90855-1
23 https://doi.org/10.1016/0006-8993(81)90562-x
24 https://doi.org/10.1016/0006-8993(83)90729-1
25 https://doi.org/10.1016/0014-2999(82)90599-4
26 https://doi.org/10.1016/0024-3205(78)90044-9
27 https://doi.org/10.1016/0024-3205(78)90538-6
28 https://doi.org/10.1016/0024-3205(80)90073-9
29 https://doi.org/10.1016/0024-3205(83)90725-7
30 https://doi.org/10.1016/0024-3205(84)90391-6
31 https://doi.org/10.1016/0024-3205(85)90041-4
32 https://doi.org/10.1016/0024-3205(86)90652-1
33 https://doi.org/10.1016/0024-3205(87)90255-4
34 https://doi.org/10.1016/0160-5402(87)90048-9
35 https://doi.org/10.1016/0883-2889(86)90002-x
36 https://doi.org/10.1016/0883-2889(86)90003-1
37 https://doi.org/10.1016/0883-2889(86)90139-5
38 https://doi.org/10.1016/0883-2897(86)90035-8
39 https://doi.org/10.1016/0883-2897(86)90132-7
40 https://doi.org/10.1016/0883-2897(86)90134-0
41 https://doi.org/10.1016/s0047-0740(85)80003-6
42 https://doi.org/10.1038/jcbfm.1986.26
43 https://doi.org/10.1038/jcbfm.1986.96
44 https://doi.org/10.1073/pnas.78.4.2620
45 https://doi.org/10.1097/00004728-198501000-00024
46 https://doi.org/10.1111/j.1471-4159.1985.tb12891.x
47 https://doi.org/10.1111/j.1471-4159.1988.tb01830.x
48 https://doi.org/10.1126/science.2878495
49 https://doi.org/10.1126/science.6334363
50 https://doi.org/10.1126/science.6604315
51 https://doi.org/10.1146/annurev.ph.43.030181.001323
52 schema:datePublished 1988-05
53 schema:datePublishedReg 1988-05-01
54 schema:description The regional pharmacokinetic behavior in baboon brain of 18F-fluoroethyl- and 18F-fluoropropylspiperone (18FESP, 18FPSP) at specific activities greater than or equal to 1000 Ci/mmol was studied with PET. Four hours after injection of 5-10 mCi 18FESP, uptake in striatum was 0.048% +/- 0.005% of injected dose per cm3, which is almost the same as with 18F- and 11C-methylspiperone. While 18FPSP was taken up in much smaller amounts than 18FESP, striatum to cerebellum activity ratios were quite similar for both ligands (about 9 to 10 at 4 h p.i.). Because of its higher striatal uptake, 18FESP seems to be better suited for PET. Furthermore, relative binding to S2 receptors was much smaller for FESP: competing cold S2 antagonists (ritanserin, ketanserin) did not alter 18FESP binding to striatum, concurrently reducing uptake in frontal cortex by only 15%-20%. With coinjection of increasing amounts of cold FESP, saturation of 18FESP binding to striatum occurred at doses exceeding 10 micrograms per kg. Quantitative analysis of radiolabelled ligand in arterial plasma (decrease to 8% at 4 h p.i.) demonstrated identical metabolic turnover for both ligands. Direct use of binding fractions from the saturation curve resulted in overestimation of the receptor density in striatum. Using the 18FESP plasma concentration time curve and the dynamic uptake data, k3 of a three compartment model could be determined by non linear regression. However, dramatic changes of the dependence of k3 on the specifically bound ligand concentration were observed even at small loading doses of FESP. Estimation of Bmax yielded a D2 receptor density of only 6 pmol per cm3 in baboon striatum.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree false
58 schema:isPartOf N659bd6fc09cd49c8bceac72cb380e5c8
59 Ne2c2e91ed7014a78b46ebf99db6936f5
60 sg:journal.1297401
61 schema:name PET measurement of D2 and S2 receptor binding of 3-N-([2′-18F]fluoroethyl)spiperone in baboon brain
62 schema:pagination 80-87
63 schema:productId N02cddbad421942c1ae7839c852885ea3
64 N79964d57f4344bfe8d36a6a6ad6af444
65 N9d91b5b25c414bdb95b0dc96578d4919
66 Nc4b47f94e7ae458f8902e7512abf99f6
67 Ne86cedc38f9e4565abf561d2e049e33d
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012549766
69 https://doi.org/10.1007/bf00253446
70 schema:sdDatePublished 2019-04-11T14:02
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher N344a4394e11d4e8f869c42b5bb5474b2
73 schema:url http://link.springer.com/10.1007/BF00253446
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N02cddbad421942c1ae7839c852885ea3 schema:name readcube_id
78 schema:value 3bca2f6390ef8b9efe8726fdfcd2e2b426d6b5ab020f89f6535bc97ceff2546e
79 rdf:type schema:PropertyValue
80 N072bc81f7f2c4e67b64f0b8354bfe5ef rdf:first sg:person.01324373457.25
81 rdf:rest Nd36c685b49d24e99b414035a2c1bb8cc
82 N08b2b99ac1264d7589814d1d73a09ddb rdf:first sg:person.014142346732.64
83 rdf:rest rdf:nil
84 N0ad5d66494af404db2c0a07d888746e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Receptors, Dopamine D2
86 rdf:type schema:DefinedTerm
87 N17521ee4922b42f483b647f6387a0de3 rdf:first sg:person.015044471104.57
88 rdf:rest N08b2b99ac1264d7589814d1d73a09ddb
89 N220a81d4426043b89f8596db536d4d37 rdf:first sg:person.0747547562.15
90 rdf:rest N072bc81f7f2c4e67b64f0b8354bfe5ef
91 N2d5f121954cf41f6a2a5ad0424213296 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Male
93 rdf:type schema:DefinedTerm
94 N344a4394e11d4e8f869c42b5bb5474b2 schema:name Springer Nature - SN SciGraph project
95 rdf:type schema:Organization
96 N3deb7a97871144ccadd29b02c348bb93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Tomography, Emission-Computed
98 rdf:type schema:DefinedTerm
99 N3f59049e4d174c399d51e8cf896fe3d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Corpus Striatum
101 rdf:type schema:DefinedTerm
102 N43db6dc89c664d81845779e07aaf1984 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Spiperone
104 rdf:type schema:DefinedTerm
105 N536672facbfd4722bc94ff2b73c7635a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Fluorine Radioisotopes
107 rdf:type schema:DefinedTerm
108 N5ce1b20461e844b7bb3b43daab9f3ec7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Papio
110 rdf:type schema:DefinedTerm
111 N659bd6fc09cd49c8bceac72cb380e5c8 schema:issueNumber 2
112 rdf:type schema:PublicationIssue
113 N79964d57f4344bfe8d36a6a6ad6af444 schema:name doi
114 schema:value 10.1007/bf00253446
115 rdf:type schema:PropertyValue
116 N7c4f4f3c5c294fa28ed66bf529fe9571 schema:name Institut für Chemie 1 (Nuklearchemie) der Kernforschungsanlage Jülich GmbH, D-5170, Jülich, Federal Republic of Germany
117 rdf:type schema:Organization
118 N9d91b5b25c414bdb95b0dc96578d4919 schema:name pubmed_id
119 schema:value 2968911
120 rdf:type schema:PropertyValue
121 Na0c180ff56de460484da6bd07964c36a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Brain
123 rdf:type schema:DefinedTerm
124 Nb823b4a9e5bd4aca834d23fb183ea5a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Receptors, Serotonin
126 rdf:type schema:DefinedTerm
127 Nc4b47f94e7ae458f8902e7512abf99f6 schema:name dimensions_id
128 schema:value pub.1012549766
129 rdf:type schema:PropertyValue
130 Nc78457291a124f218d8663193f4da79d schema:name Institut für Chemie 1 (Nuklearchemie) der Kernforschungsanlage Jülich GmbH, D-5170, Jülich, Federal Republic of Germany
131 rdf:type schema:Organization
132 Ncad74c27ddf048159e08bb4945c2333a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Animals
134 rdf:type schema:DefinedTerm
135 Nd36c685b49d24e99b414035a2c1bb8cc rdf:first sg:person.01256260257.36
136 rdf:rest Nf8023e10c4614d7abb6b17fcfd4c93eb
137 Nd7d17cf72ea346fdb4e2346d83262401 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Receptors, Dopamine
139 rdf:type schema:DefinedTerm
140 Nd95a0c4fdba4414c81274758fa02c157 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Cerebellum
142 rdf:type schema:DefinedTerm
143 Ne2c2e91ed7014a78b46ebf99db6936f5 schema:volumeNumber 14
144 rdf:type schema:PublicationVolume
145 Ne86cedc38f9e4565abf561d2e049e33d schema:name nlm_unique_id
146 schema:value 7606882
147 rdf:type schema:PropertyValue
148 Nedd7f0522c81406d9598a3033f32ee62 rdf:first sg:person.01342401277.27
149 rdf:rest N220a81d4426043b89f8596db536d4d37
150 Nf3a8d537d9da4afabf441f8b1fb915d9 schema:name Institut für Chemie 1 (Nuklearchemie) der Kernforschungsanlage Jülich GmbH, D-5170, Jülich, Federal Republic of Germany
151 rdf:type schema:Organization
152 Nf8023e10c4614d7abb6b17fcfd4c93eb rdf:first sg:person.010027141254.23
153 rdf:rest N17521ee4922b42f483b647f6387a0de3
154 anzsrc-for:02 schema:inDefinedTermSet anzsrc-for:
155 schema:name Physical Sciences
156 rdf:type schema:DefinedTerm
157 anzsrc-for:0299 schema:inDefinedTermSet anzsrc-for:
158 schema:name Other Physical Sciences
159 rdf:type schema:DefinedTerm
160 sg:journal.1297401 schema:issn 1619-7070
161 1619-7089
162 schema:name European Journal of Nuclear Medicine and Molecular Imaging
163 rdf:type schema:Periodical
164 sg:person.010027141254.23 schema:affiliation https://www.grid.ac/institutes/grid.418034.a
165 schema:familyName Hebold
166 schema:givenName Ira
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010027141254.23
168 rdf:type schema:Person
169 sg:person.01256260257.36 schema:affiliation N7c4f4f3c5c294fa28ed66bf529fe9571
170 schema:familyName Laufer
171 schema:givenName Peter
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256260257.36
173 rdf:type schema:Person
174 sg:person.01324373457.25 schema:affiliation Nc78457291a124f218d8663193f4da79d
175 schema:familyName Stöcklin
176 schema:givenName Gerhard
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324373457.25
178 rdf:type schema:Person
179 sg:person.01342401277.27 schema:affiliation Nf3a8d537d9da4afabf441f8b1fb915d9
180 schema:familyName Coenen
181 schema:givenName Heinz H.
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342401277.27
183 rdf:type schema:Person
184 sg:person.014142346732.64 schema:affiliation https://www.grid.ac/institutes/grid.418034.a
185 schema:familyName Heiss
186 schema:givenName Wolf-Dieter
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014142346732.64
188 rdf:type schema:Person
189 sg:person.015044471104.57 schema:affiliation https://www.grid.ac/institutes/grid.418034.a
190 schema:familyName Pawlik
191 schema:givenName Günter
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015044471104.57
193 rdf:type schema:Person
194 sg:person.0747547562.15 schema:affiliation https://www.grid.ac/institutes/grid.418034.a
195 schema:familyName Wienhard
196 schema:givenName Klaus
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747547562.15
198 rdf:type schema:Person
199 sg:pub.10.1007/bf00256924 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024770401
200 https://doi.org/10.1007/bf00256924
201 rdf:type schema:CreativeWork
202 https://app.dimensions.ai/details/publication/pub.1079428156 schema:CreativeWork
203 https://app.dimensions.ai/details/publication/pub.1079429305 schema:CreativeWork
204 https://app.dimensions.ai/details/publication/pub.1081911162 schema:CreativeWork
205 https://doi.org/10.1002/jlcr.2580240108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037077754
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1002/jlcr.2580250211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031792846
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/0006-8993(77)90855-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028436894
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/0006-8993(81)90562-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040259684
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/0006-8993(83)90729-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043649336
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/0014-2999(82)90599-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008571668
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/0024-3205(78)90044-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042247442
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/0024-3205(78)90538-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032538949
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/0024-3205(80)90073-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027537322
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/0024-3205(83)90725-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041929739
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/0024-3205(84)90391-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014293857
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/0024-3205(85)90041-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034830571
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/0024-3205(86)90652-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021716825
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/0024-3205(87)90255-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002177021
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/0160-5402(87)90048-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034096003
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/0883-2889(86)90002-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046384445
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/0883-2889(86)90003-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035077263
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/0883-2889(86)90139-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003587147
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/0883-2897(86)90035-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012333849
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/0883-2897(86)90132-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035085421
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/0883-2897(86)90134-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011557895
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/s0047-0740(85)80003-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012375640
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1038/jcbfm.1986.26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001791964
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1038/jcbfm.1986.96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021721941
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1073/pnas.78.4.2620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050366261
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1097/00004728-198501000-00024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023280889
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1111/j.1471-4159.1985.tb12891.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023390610
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1111/j.1471-4159.1988.tb01830.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010581358
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1126/science.2878495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062568977
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1126/science.6334363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062636824
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1126/science.6604315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062639159
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1146/annurev.ph.43.030181.001323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045475939
268 rdf:type schema:CreativeWork
269 https://www.grid.ac/institutes/grid.418034.a schema:alternateName Max Planck Institute for Metabolism Research
270 schema:name Max-Planck-Institut für Neurologische Forschung, D-5000, Köln 30, Federal Republic of Germany
271 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...