HLA-D and -DR antigens in genetic analysis of insulin dependent diabetes mellitus View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1981-08

AUTHORS

P. Platz, B. K. Jakobsen, N. Morling, L. P. Ryder, A. Svejgaard, M. Thomsen, M. Christy, H. Kromann, J. Benn, J. Nerup, A. Green, M. Hauge

ABSTRACT

Three groups of patients with insulin-dependent diabetes mellitus, ascertained by different procedures, were investigated for HLA-A, B, C and D antigens (n = 164), and a subset (n = 93) for HLA-DR. Both HLA-D/DR3 and D/DR4 were strongly positively associated and D/DR2 was negatively associated with insulin-dependent diabetes. HLA-DR+ was found to be a better marker for insulin-dependent diabetes than Dw4. The HLA-B associations (B8, B15 and B18) were clearly secondary to the increases of HLA-D/DR3 and D/DR 4. The HLA associations did not differ between familial and isolated cases indicating that these two groups may well have a common genetic background. Based on analysis of HLA-haplotype sharing in affected sibling pairs, a simple dominant model of inheritance could be ruled out, and a simple recessive model was found unlikely. The relative risks for the HLA-Dw3,4 and HLA-DR3,4 phenotype were 21.2 and 44.4 respectively and exceeded those of both the HLA-Dw3 and HLA-DR3 (5.6 and 4.3) as well as the HLA-Dw4 and DR4 (10.1 and 10.5) phenotypes. This argues against an intermediate genetic model but further studies are needed to clarify whether there is more than one susceptibility gene for insulin-dependent diabetes mellitus within the HLA-system. More... »

PAGES

108-115

References to SciGraph publications

  • 1980-01. Type 1 diabetes and the HLA-D locus in DIABETOLOGIA
  • 1981-04. Epidemiological studies of diabetes mellitus in Denmark in DIABETOLOGIA
  • 1977. The Genetics of HLA and Disease Associations in MEASURING SELECTION IN NATURAL POPULATIONS
  • 1978-05. Type I diabetes mellitus in DIABETOLOGIA
  • 1979. HLA Studies in Diabetics in TREATMENT OF EARLY DIABETES
  • 1978-12. HLA-typing in juvenile diabetics with and without positive family history and in families with one and two diabetic siblings in DIABETOLOGIA
  • 1980. HLA antigens and diabetes in INHERITED DISORDERS OF CARBOHYDRATE METABOLISM
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00251276

    DOI

    http://dx.doi.org/10.1007/bf00251276

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049595722

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6167481


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    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00251276'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00251276'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00251276'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00251276'


     

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