The in vivo inhibition of transport enzyme activities by chloroquine in different organs of rat is reversible View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-03

AUTHORS

Sucheta Chandra, Gautam Adhikary, Rita Sikdar, Parimal C. Sen

ABSTRACT

The antimalarial drug chloroquine is found to inhibit Na+, K+-ATPase, Ca2+, Mg2+-ATPase, Ca2+-ATPase, pNPPase and acetylcholinesterase activities in different organs of rat in vivo when injected for a certain periods of time. The inhibition seems to be due to the changes in the level of phospholipid, cholesterol and the fatty acid of the lipid and the alteration of the fluidity of the microsomal membranes. However, the enzyme activities return to the normal level in about 2–3 weeks after the discontinuation of the drug suggesting that the drug effect is reversible. More... »

PAGES

15-21

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00249690

DOI

http://dx.doi.org/10.1007/bf00249690

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052914416

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1336812


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