Der Einfluß des Urin-pH auf die Ausscheidung einiger acetylierter Sulfonamide View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1964-03

AUTHORS

W. Braun, J. Adlung, G. Malorny

ABSTRACT

Clearance-Untersuchungen am Hund bei wechselnden Urin-pH-Werten zeigen, daß die N4-acetylierten Sulfonamide Acetylsulfisomidin, Acetylsulfaethidol und Acetylsulfamethoxydiazin im alkalischen Urin bedeutend schneller ausgeschieden werden als im sauren Urin. Die Ausscheidungsgeschwindigkeit der acetylierten Substanzen liegt immer über derjenigen der nichtsubstituierten Verbindungen. Im sauren Urin wird dieser Unterschied ganz besonders deutlich. Die acetylierten Sulfonamide beteiligen sich demnach — ebenso wie ihre Muttersubstanzen — an pH-abhängigen Diffusionen zwischen Tubuluslumen und umgebenden Capillaren. Daraus kann geschlossen werden, daß ihre Ausscheidung durch tubuläre Sekretion und pH-abhängige Rückdiffusion bestimmt wird. More... »

PAGES

185-190

References to SciGraph publications

  • 1963-09. Zur Bedeutung pH-abhängiger Diffusionsvorgänge für die Nierenfunktion in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/bf00247010

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    http://dx.doi.org/10.1007/bf00247010

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/14347834


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