Aromatic biosynthesis View Full Text


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Article Info

DATE

1953-01

AUTHORS

Bernard D. Davis, Ulrich Weiss

ABSTRACT

Certain mutants of E. coli and A. aerogenes require for growth a group of five aromatic metabolites (tyrosine, phenylalanine, tryptophan, p-aminobenzoic acid, and p-hydroxybenzoic acid). Some of these strains accumulate 5-dehydroquinic acid (DHQ) in their culture filtrates, and others can utilize this compound as a growth factor. The latter group of strains exhibit a very limited response to this compound, and a less limited response to its metabolic successors, 5-dehydroshikimic acid and shikimic acid; but these strains yield various types of secondary mutants that respond well to these intermediates. Furthermore, replacement of glucose by lactate or succinate as carbon source leads to good response of the Aerobacter mutant to DHQ without the need for a secondary mutation. It is concluded that DHQ is a normal intermediate in aromatic biosynthesis.The Aerobacter mutants that can utilize DHQ respond equally well to quinic acid. Evidence is presented, however, that quinic acid is not a metabolite in E. coli, and even in Aerobacter may be used through a side reaction rather than a normal biosynthetic step. More... »

PAGES

1-15

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00246089

DOI

http://dx.doi.org/10.1007/bf00246089

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012084816

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/13132923


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