Auditory brainstem response thresholds in a mouse mutant with selective outer hair cell loss View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-01

AUTHORS

A. Schrott, K. Stephan, H. Spoendlin

ABSTRACT

Mutant animals with a particular type of cochlear pathology are an excellent model for studying the functional role of various cells of the cochlea. In homozygous WV/WV mutant mice we found a selective loss of outer hair cells as a constant defect with no progressive degeneration of the organ of Corti. The mice were followed throughout their lives and exhibited auditory brainstem responses that were elevated to about 50 dB SPL as compared to normal control animals. Sequential temporal bone studies showed that there was a selective loss of outer hair cells throughout the entire cochlea as seen in surface preparations. The inner hair cells were present in normal numbers and appeared to be essentially normal. More... »

PAGES

8-11

References to SciGraph publications

  • 1974-06. The block-surface technique for evaluation of cochlear pathology in EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
  • 1975-01. Effect of absence of cochlear outer hair cells on behavioural auditory threshold in NATURE
  • 1976-03. Hereditary deafness in the Dalmatian dog in EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
  • 1988-09. Intermediate filaments in the cochleas of normal and mutant (w/wv, sl/sld) mice in EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00240940

    DOI

    http://dx.doi.org/10.1007/bf00240940

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1014030273

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2310554


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