Light and electron microscopic observation on the appearance of immunoreactive LHRH in perinatal rat hypothalamus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1980-12

AUTHORS

H. Kawano, Y. G. Watanabe, S. Daikoku

ABSTRACT

The appearance and localization of LHRH were studied in the developing hypothalamus of perinatal rats using the unlabelled antibody method. By light microscopy, immunoreactive LHRH was first detected as brown dots on day 18.5 of gestation in the OVLT and on day 19.5 in the median eminence, respectively. When the median eminence was examined by the preembedding immunohistochemistry technique for electron microscopy, the occurrence of immunoreactive LHRH fibers could be demonstrated on day 18.5. These fibers were thin and very occasionally encountered near the surface of the lateral regions of the median eminence. The axoplasm contained a few immunopositive secretory granules and also extragranular immunoreactive products. With development, a gradual increase was noted both in number and size of nerve fibers with a concomitant accumulation of secretory granules within the axoplasm.A possible physiological significance of LHRH is discussed in relation to the onset of hypothalamo-hypophysial system in fetal life. More... »

PAGES

465-474

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00237891

DOI

http://dx.doi.org/10.1007/bf00237891

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045694889

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7004641


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