Increased Ca-uptake of presynaptic terminals during long-term potentiation in hippocampal slices View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-05

AUTHORS

D. V. Agoston, U. Kuhnt

ABSTRACT

A combined electrophysiological and neurochemical study was performed on the CA1 area of hippocampal slices in an attempt to identify changes in presynaptic nerve terminal function in long-term potentiation (LTP). After controlled induction of LTP in CA1, the activated region was subjected to subcellular fractionation followed by 45Ca2+ uptake determinations. Synaptosomes prepared from slices in which LTP has been induced showed a faster risetime and a higher level of saturation for K+-induced Ca-uptake than those derived from unstimulated and stimulated control slices. These findings point to a participation of presynaptic terminals in long-term potentiation. More... »

PAGES

663-668

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00236048

DOI

http://dx.doi.org/10.1007/bf00236048

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018592635

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3720895


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