Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1971-12

AUTHORS

J. W. Olney, Oi Lan Ho, V. Rhee

ABSTRACT

The brains and retinas of infant mice were examined following subcutaneous administration of monosodium glutamate (MSG) and structurally related compounds in an attempt to clarify the molecular specificity of MSG-induced neuropathology. Based on the effects on the infant retina and hypothalamus all compounds could be placed into one of four groups: 1. Those equipotent with L-MSG in necrosing neurons. 2. Those substantially more potent than L-MSG in necrosing neurons. 3. Those which affect non-neuronal components (glial, ependymal, Muller cells) without appreciable effects on neurons. 4. Those with no cytotoxic effects. Except for L-cysteine, all neurotoxic compounds were acidic amino acids known to excite neurones, the most potent neurotoxic compounds being those which are powerful neuroexcitants (N-methyl DL-aspartic and DL-homocysteic acids). The exception posed by L-cysteine may be more apparent than real in that the in vivo conversion of the SH terminal to a more acidic group (SO2H or SO3H) could account for its neurotoxicity. The close correspondence in molecular specificities associated with neurotoxic and neuroexcitatory properties of simple amino acids suggests the two phenomena may be governed by similar mechanisms of action. More... »

PAGES

61-76

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00234911

DOI

http://dx.doi.org/10.1007/bf00234911

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038657763

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/5157537


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aspartic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cysteine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glutamine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homocysteine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypothalamus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Electron", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retina", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA", 
          "id": "http://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Olney", 
        "givenName": "J. W.", 
        "id": "sg:person.0622564136.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622564136.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA", 
          "id": "http://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ho", 
        "givenName": "Oi Lan", 
        "id": "sg:person.056543160.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.056543160.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA", 
          "id": "http://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rhee", 
        "givenName": "V.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/227609b0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031072147", 
          "https://doi.org/10.1038/227609b0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/233058a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047281325", 
          "https://doi.org/10.1038/233058a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/229411a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014692947", 
          "https://doi.org/10.1038/229411a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1971-12", 
    "datePublishedReg": "1971-12-01", 
    "description": "The brains and retinas of infant mice were examined following subcutaneous administration of monosodium glutamate (MSG) and structurally related compounds in an attempt to clarify the molecular specificity of MSG-induced neuropathology. Based on the effects on the infant retina and hypothalamus all compounds could be placed into one of four groups: 1. Those equipotent with L-MSG in necrosing neurons. 2. Those substantially more potent than L-MSG in necrosing neurons. 3. Those which affect non-neuronal components (glial, ependymal, Muller cells) without appreciable effects on neurons. 4. Those with no cytotoxic effects. Except for L-cysteine, all neurotoxic compounds were acidic amino acids known to excite neurones, the most potent neurotoxic compounds being those which are powerful neuroexcitants (N-methyl DL-aspartic and DL-homocysteic acids). The exception posed by L-cysteine may be more apparent than real in that the in vivo conversion of the SH terminal to a more acidic group (SO2H or SO3H) could account for its neurotoxicity. The close correspondence in molecular specificities associated with neurotoxic and neuroexcitatory properties of simple amino acids suggests the two phenomena may be governed by similar mechanisms of action.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf00234911", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1005581", 
        "issn": [
          "0014-4819", 
          "1432-1106"
        ], 
        "name": "Experimental Brain Research", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "keywords": [
      "monosodium glutamate", 
      "non-neuronal components", 
      "potent neurotoxic compound", 
      "cytotoxic effects", 
      "mouse central nervous system", 
      "central nervous system", 
      "neurotoxic compounds", 
      "neuroexcitatory properties", 
      "subcutaneous administration", 
      "infant mice", 
      "infant retina", 
      "nervous system", 
      "neurons", 
      "vivo conversion", 
      "retina", 
      "amino acids", 
      "similar mechanism", 
      "group", 
      "molecular specificity", 
      "neuropathology", 
      "appreciable effect", 
      "neurotoxicity", 
      "neurones", 
      "administration", 
      "mice", 
      "specificity", 
      "neuroexcitants", 
      "brain", 
      "equipotent", 
      "neurotoxic", 
      "effect", 
      "glutamate", 
      "acidic amino acids", 
      "acid", 
      "cysteine", 
      "action", 
      "terminals", 
      "mechanism", 
      "compounds", 
      "exception", 
      "attempt", 
      "close correspondence", 
      "components", 
      "simple amino acids", 
      "conversion", 
      "acidic", 
      "system", 
      "phenomenon", 
      "properties", 
      "acidic groups", 
      "correspondence", 
      "sulfur", 
      "MSG-induced neuropathology", 
      "necrosing neurons", 
      "excite neurones", 
      "powerful neuroexcitants", 
      "SH terminal", 
      "infant mouse central nervous system"
    ], 
    "name": "Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system", 
    "pagination": "61-76", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1038657763"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00234911"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "5157537"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00234911", 
      "https://app.dimensions.ai/details/publication/pub.1038657763"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_152.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf00234911"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00234911'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00234911'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00234911'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00234911'


 

This table displays all metadata directly associated to this object as RDF triples.

184 TRIPLES      21 PREDICATES      97 URIs      86 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00234911 schema:about N3271b3d6119a4d24817741b6e2a7e88c
2 N33564886d7064a41bb3e340ef8ea0e00
3 N44939de1d02c46939f9619b7ea94de6d
4 N46b40b8968bf4159a4416cb2eafd3ada
5 N693347b858934b39bfd1bb22d63311bf
6 N6aad7c1f21c543cc8e196def070cd7a8
7 N78e11bd56ee04b4a810ba002b54841ea
8 N80af2730f00e42b1b20184700ea4ce9d
9 N8b889dbe55cf421393b30a89bb052285
10 Nda5797ce76f94400b2a4fe1e32bfd7f6
11 anzsrc-for:11
12 anzsrc-for:1109
13 schema:author N8c3c4089411d4652bf2768d9f0903655
14 schema:citation sg:pub.10.1038/227609b0
15 sg:pub.10.1038/229411a0
16 sg:pub.10.1038/233058a0
17 schema:datePublished 1971-12
18 schema:datePublishedReg 1971-12-01
19 schema:description The brains and retinas of infant mice were examined following subcutaneous administration of monosodium glutamate (MSG) and structurally related compounds in an attempt to clarify the molecular specificity of MSG-induced neuropathology. Based on the effects on the infant retina and hypothalamus all compounds could be placed into one of four groups: 1. Those equipotent with L-MSG in necrosing neurons. 2. Those substantially more potent than L-MSG in necrosing neurons. 3. Those which affect non-neuronal components (glial, ependymal, Muller cells) without appreciable effects on neurons. 4. Those with no cytotoxic effects. Except for L-cysteine, all neurotoxic compounds were acidic amino acids known to excite neurones, the most potent neurotoxic compounds being those which are powerful neuroexcitants (N-methyl DL-aspartic and DL-homocysteic acids). The exception posed by L-cysteine may be more apparent than real in that the in vivo conversion of the SH terminal to a more acidic group (SO2H or SO3H) could account for its neurotoxicity. The close correspondence in molecular specificities associated with neurotoxic and neuroexcitatory properties of simple amino acids suggests the two phenomena may be governed by similar mechanisms of action.
20 schema:genre article
21 schema:isAccessibleForFree false
22 schema:isPartOf N5409e579b39c4937af006d59e1f523f7
23 Nea005d1feb8b47748a36cb9dc251f79f
24 sg:journal.1005581
25 schema:keywords MSG-induced neuropathology
26 SH terminal
27 acid
28 acidic
29 acidic amino acids
30 acidic groups
31 action
32 administration
33 amino acids
34 appreciable effect
35 attempt
36 brain
37 central nervous system
38 close correspondence
39 components
40 compounds
41 conversion
42 correspondence
43 cysteine
44 cytotoxic effects
45 effect
46 equipotent
47 exception
48 excite neurones
49 glutamate
50 group
51 infant mice
52 infant mouse central nervous system
53 infant retina
54 mechanism
55 mice
56 molecular specificity
57 monosodium glutamate
58 mouse central nervous system
59 necrosing neurons
60 nervous system
61 neuroexcitants
62 neuroexcitatory properties
63 neurones
64 neurons
65 neuropathology
66 neurotoxic
67 neurotoxic compounds
68 neurotoxicity
69 non-neuronal components
70 phenomenon
71 potent neurotoxic compound
72 powerful neuroexcitants
73 properties
74 retina
75 similar mechanism
76 simple amino acids
77 specificity
78 subcutaneous administration
79 sulfur
80 system
81 terminals
82 vivo conversion
83 schema:name Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system
84 schema:pagination 61-76
85 schema:productId N1c038d25cfc54d0795917a14b1db70d3
86 Nc175f27b6f5443cbaa76d2e98c55e204
87 Ne961e37fea4b4d57a7192002402bb929
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038657763
89 https://doi.org/10.1007/bf00234911
90 schema:sdDatePublished 2021-12-01T19:04
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher Ndd9fc8cb22c2476e87b7fa7919ab0930
93 schema:url https://doi.org/10.1007/bf00234911
94 sgo:license sg:explorer/license/
95 sgo:sdDataset articles
96 rdf:type schema:ScholarlyArticle
97 N1c038d25cfc54d0795917a14b1db70d3 schema:name pubmed_id
98 schema:value 5157537
99 rdf:type schema:PropertyValue
100 N2c860b6a2dc946428323865cf32274c1 schema:affiliation grid-institutes:grid.4367.6
101 schema:familyName Rhee
102 schema:givenName V.
103 rdf:type schema:Person
104 N3271b3d6119a4d24817741b6e2a7e88c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Homocysteine
106 rdf:type schema:DefinedTerm
107 N33564886d7064a41bb3e340ef8ea0e00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Amino Acids
109 rdf:type schema:DefinedTerm
110 N3a476bccc3a44f6eacf31a913194e67b rdf:first N2c860b6a2dc946428323865cf32274c1
111 rdf:rest rdf:nil
112 N4075b4e771d943e69a93fabe35fc4fc4 rdf:first sg:person.056543160.19
113 rdf:rest N3a476bccc3a44f6eacf31a913194e67b
114 N44939de1d02c46939f9619b7ea94de6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Animals
116 rdf:type schema:DefinedTerm
117 N46b40b8968bf4159a4416cb2eafd3ada schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Microscopy, Electron
119 rdf:type schema:DefinedTerm
120 N5409e579b39c4937af006d59e1f523f7 schema:volumeNumber 14
121 rdf:type schema:PublicationVolume
122 N693347b858934b39bfd1bb22d63311bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Cysteine
124 rdf:type schema:DefinedTerm
125 N6aad7c1f21c543cc8e196def070cd7a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Hypothalamus
127 rdf:type schema:DefinedTerm
128 N78e11bd56ee04b4a810ba002b54841ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Mice
130 rdf:type schema:DefinedTerm
131 N80af2730f00e42b1b20184700ea4ce9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Glutamine
133 rdf:type schema:DefinedTerm
134 N8b889dbe55cf421393b30a89bb052285 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Retina
136 rdf:type schema:DefinedTerm
137 N8c3c4089411d4652bf2768d9f0903655 rdf:first sg:person.0622564136.44
138 rdf:rest N4075b4e771d943e69a93fabe35fc4fc4
139 Nc175f27b6f5443cbaa76d2e98c55e204 schema:name doi
140 schema:value 10.1007/bf00234911
141 rdf:type schema:PropertyValue
142 Nda5797ce76f94400b2a4fe1e32bfd7f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Aspartic Acid
144 rdf:type schema:DefinedTerm
145 Ndd9fc8cb22c2476e87b7fa7919ab0930 schema:name Springer Nature - SN SciGraph project
146 rdf:type schema:Organization
147 Ne961e37fea4b4d57a7192002402bb929 schema:name dimensions_id
148 schema:value pub.1038657763
149 rdf:type schema:PropertyValue
150 Nea005d1feb8b47748a36cb9dc251f79f schema:issueNumber 1
151 rdf:type schema:PublicationIssue
152 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
153 schema:name Medical and Health Sciences
154 rdf:type schema:DefinedTerm
155 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
156 schema:name Neurosciences
157 rdf:type schema:DefinedTerm
158 sg:journal.1005581 schema:issn 0014-4819
159 1432-1106
160 schema:name Experimental Brain Research
161 schema:publisher Springer Nature
162 rdf:type schema:Periodical
163 sg:person.056543160.19 schema:affiliation grid-institutes:grid.4367.6
164 schema:familyName Ho
165 schema:givenName Oi Lan
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.056543160.19
167 rdf:type schema:Person
168 sg:person.0622564136.44 schema:affiliation grid-institutes:grid.4367.6
169 schema:familyName Olney
170 schema:givenName J. W.
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622564136.44
172 rdf:type schema:Person
173 sg:pub.10.1038/227609b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031072147
174 https://doi.org/10.1038/227609b0
175 rdf:type schema:CreativeWork
176 sg:pub.10.1038/229411a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014692947
177 https://doi.org/10.1038/229411a0
178 rdf:type schema:CreativeWork
179 sg:pub.10.1038/233058a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047281325
180 https://doi.org/10.1038/233058a0
181 rdf:type schema:CreativeWork
182 grid-institutes:grid.4367.6 schema:alternateName Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA
183 schema:name Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA
184 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...