Inhibition of Mg2+ current by single-gene mutation in Paramecium View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-05

AUTHORS

R. R. Preston, C. Kung

ABSTRACT

"Eccentric" is a newly-isolated mutant of Paramecium tetraurelia that fails to swim backwards in response to Mg2+. In the wild type, this backward swimming results from Mg2+ influx via a Mg(2+)-specific ion conductance (IMg). Voltage-clamp analysis confirmed that, as suspected, step changes in membrane potential over a physiological range fail to elicit IMg from eccentric. Further electrophysiological investigation revealed a number of additional ion-current defects in eccentric: (i) The Ca2+ current activated upon depolarization inactivates more slowly in eccentric than in the wild type, and it requires longer to recover from this inactivation. (ii) The Ca(2+)-dependent Na+ current deactivates significantly faster in the mutant. (iii) The two K+ currents observed upon hyperpolarization are reduced by > 60% in eccentric. It is difficult to envision how these varied pleiotropic effects could result from loss of a single ion current. Rather, they suggest that the eccentric mutation affects a global regulatory system. Two plausible hypotheses are discussed. More... »

PAGES

203-212

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00232624

DOI

http://dx.doi.org/10.1007/bf00232624

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051169866

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7538166


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Action Potentials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Protozoan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Recessive", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Regulator", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ion Channels", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnesium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Paramecium tetraurelia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Potassium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sodium", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "Laboratory of Molecular Biology, University of Wisconsin-Madison, 53706, Madison, Wisconsin"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Preston", 
        "givenName": "R. R.", 
        "id": "sg:person.01161131100.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161131100.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "Laboratory of Molecular Biology, University of Wisconsin-Madison, 53706, Madison, Wisconsin", 
            "Department of Genetics, University of Wisconsin-Madison, 53706, Madison, Wisconsin"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kung", 
        "givenName": "C.", 
        "id": "sg:person.01360027630.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360027630.66"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1113/expphysiol.1990.sp003458", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001717594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1984.sp015252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002682419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3495(90)82626-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004079178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1983.sp014628", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005138413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-5193(82)90130-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006260330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01869105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014557993", 
          "https://doi.org/10.1007/bf01869105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01869105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014557993", 
          "https://doi.org/10.1007/bf01869105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1991.sp018513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014672596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01869104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015204198", 
          "https://doi.org/10.1007/bf01869104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01869104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015204198", 
          "https://doi.org/10.1007/bf01869104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.84.8.2560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016378662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.86.8.2981", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022854152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1985.sp015765", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024136963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1989.sp017721", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025607556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01870947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026557071", 
          "https://doi.org/10.1007/bf01870947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01870947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026557071", 
          "https://doi.org/10.1007/bf01870947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.88.2.301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026843025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1980.sp013391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027138897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(89)90272-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027994377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(89)90272-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027994377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-6147(84)90372-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028944401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-6147(84)90372-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028944401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1991.sp018703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035639246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01869391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037245595", 
          "https://doi.org/10.1007/bf01869391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01869391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037245595", 
          "https://doi.org/10.1007/bf01869391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00392059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038227792", 
          "https://doi.org/10.1007/bf00392059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00392059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038227792", 
          "https://doi.org/10.1007/bf00392059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1987.sp016572", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038982130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/expphysiol.1990.sp003457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039795167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0143-4160(92)90054-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044762540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00196923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044988855", 
          "https://doi.org/10.1007/bf00196923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00196923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044988855", 
          "https://doi.org/10.1007/bf00196923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.ph.53.030191.001521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045069125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.ph.52.030190.001353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047985615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00196922", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048686130", 
          "https://doi.org/10.1007/bf00196922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00196922", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048686130", 
          "https://doi.org/10.1007/bf00196922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(90)90250-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050030558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-70408-6_2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050274307", 
          "https://doi.org/10.1007/978-3-642-70408-6_2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1085/jgp.100.2.233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051812241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/325156a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052080725", 
          "https://doi.org/10.1038/325156a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3495(89)82922-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052376539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01871217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053221652", 
          "https://doi.org/10.1007/bf01871217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01871217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053221652", 
          "https://doi.org/10.1007/bf01871217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.103199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062443464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2169650", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062525155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2218533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062527662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.1991.260.6.c1158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078181863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.1989.257.5.h1663", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079075068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.1989.257.1.c141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079313014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079424431", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079673955", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080299631", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081563850", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1994-05", 
    "datePublishedReg": "1994-05-01", 
    "description": "\"Eccentric\" is a newly-isolated mutant of Paramecium tetraurelia that fails to swim backwards in response to Mg2+. In the wild type, this backward swimming results from Mg2+ influx via a Mg(2+)-specific ion conductance (IMg). Voltage-clamp analysis confirmed that, as suspected, step changes in membrane potential over a physiological range fail to elicit IMg from eccentric. Further electrophysiological investigation revealed a number of additional ion-current defects in eccentric: (i) The Ca2+ current activated upon depolarization inactivates more slowly in eccentric than in the wild type, and it requires longer to recover from this inactivation. (ii) The Ca(2+)-dependent Na+ current deactivates significantly faster in the mutant. (iii) The two K+ currents observed upon hyperpolarization are reduced by > 60% in eccentric. It is difficult to envision how these varied pleiotropic effects could result from loss of a single ion current. Rather, they suggest that the eccentric mutation affects a global regulatory system. Two plausible hypotheses are discussed.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00232624", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2508970", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2586054", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1012006", 
        "issn": [
          "0022-2631", 
          "1432-1424"
        ], 
        "name": "The Journal of Membrane Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "139"
      }
    ], 
    "name": "Inhibition of Mg2+ current by single-gene mutation in Paramecium", 
    "pagination": "203-212", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00232624"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f3c0f8eca4f1ce93203405bc79cba29edc9a22e724f3d95286bee9262a431321"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1051169866"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0211301"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7538166"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00232624", 
      "https://app.dimensions.ai/details/publication/pub.1051169866"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T09:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000375_0000000375/records_91459_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2FBF00232624"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00232624'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00232624'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00232624'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00232624'


 

This table displays all metadata directly associated to this object as RDF triples.

276 TRIPLES      21 PREDICATES      87 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00232624 schema:about N0f83e896e0844260ab3ecb3d9aa21253
2 N18bb5fc5ad6644aaacd644fec1bead71
3 N198255da2edb45b38c1331f0f5b8d97e
4 N230b932b959843979fdecafd4f4f9c54
5 N2ab7f630ebd34618bf917ecbbf14afbb
6 N2afcf41f2a694cd9acadd65d0f6a672c
7 N4569ca5a45a149ed83ec180b65d6c0f3
8 N59a656dc55af467eaa6d96f2bae77361
9 N64bd431542cd486ca7d4516edfd347bb
10 Na87c9b54e551471785e81a024c8c37b7
11 Nb61a2a5becef46069eb9049ab3cb68ae
12 Nd4666210d7c241ab80cc0e2731f3f9c8
13 Ne58e297942ef44a998fc7ee140a23d08
14 Nf7f6bfe4f07e4ce2a9e57efe8139c873
15 Nfa5104b5e601400a934805bab5b70019
16 anzsrc-for:06
17 anzsrc-for:0601
18 schema:author Nb49f494d1ef74828a9dee8aa8eb5d143
19 schema:citation sg:pub.10.1007/978-3-642-70408-6_2
20 sg:pub.10.1007/bf00196922
21 sg:pub.10.1007/bf00196923
22 sg:pub.10.1007/bf00392059
23 sg:pub.10.1007/bf01869104
24 sg:pub.10.1007/bf01869105
25 sg:pub.10.1007/bf01869391
26 sg:pub.10.1007/bf01870947
27 sg:pub.10.1007/bf01871217
28 sg:pub.10.1038/325156a0
29 https://app.dimensions.ai/details/publication/pub.1079424431
30 https://app.dimensions.ai/details/publication/pub.1079673955
31 https://app.dimensions.ai/details/publication/pub.1080299631
32 https://app.dimensions.ai/details/publication/pub.1081563850
33 https://doi.org/10.1016/0006-2952(89)90272-4
34 https://doi.org/10.1016/0022-5193(82)90130-8
35 https://doi.org/10.1016/0092-8674(90)90250-i
36 https://doi.org/10.1016/0143-4160(92)90054-v
37 https://doi.org/10.1016/0165-6147(84)90372-9
38 https://doi.org/10.1016/s0006-3495(89)82922-4
39 https://doi.org/10.1016/s0006-3495(90)82626-6
40 https://doi.org/10.1073/pnas.84.8.2560
41 https://doi.org/10.1073/pnas.86.8.2981
42 https://doi.org/10.1083/jcb.88.2.301
43 https://doi.org/10.1085/jgp.100.2.233
44 https://doi.org/10.1113/expphysiol.1990.sp003457
45 https://doi.org/10.1113/expphysiol.1990.sp003458
46 https://doi.org/10.1113/jphysiol.1980.sp013391
47 https://doi.org/10.1113/jphysiol.1983.sp014628
48 https://doi.org/10.1113/jphysiol.1984.sp015252
49 https://doi.org/10.1113/jphysiol.1985.sp015765
50 https://doi.org/10.1113/jphysiol.1987.sp016572
51 https://doi.org/10.1113/jphysiol.1989.sp017721
52 https://doi.org/10.1113/jphysiol.1991.sp018513
53 https://doi.org/10.1113/jphysiol.1991.sp018703
54 https://doi.org/10.1126/science.103199
55 https://doi.org/10.1126/science.2169650
56 https://doi.org/10.1126/science.2218533
57 https://doi.org/10.1146/annurev.ph.52.030190.001353
58 https://doi.org/10.1146/annurev.ph.53.030191.001521
59 https://doi.org/10.1152/ajpcell.1989.257.1.c141
60 https://doi.org/10.1152/ajpcell.1991.260.6.c1158
61 https://doi.org/10.1152/ajpheart.1989.257.5.h1663
62 schema:datePublished 1994-05
63 schema:datePublishedReg 1994-05-01
64 schema:description "Eccentric" is a newly-isolated mutant of Paramecium tetraurelia that fails to swim backwards in response to Mg2+. In the wild type, this backward swimming results from Mg2+ influx via a Mg(2+)-specific ion conductance (IMg). Voltage-clamp analysis confirmed that, as suspected, step changes in membrane potential over a physiological range fail to elicit IMg from eccentric. Further electrophysiological investigation revealed a number of additional ion-current defects in eccentric: (i) The Ca2+ current activated upon depolarization inactivates more slowly in eccentric than in the wild type, and it requires longer to recover from this inactivation. (ii) The Ca(2+)-dependent Na+ current deactivates significantly faster in the mutant. (iii) The two K+ currents observed upon hyperpolarization are reduced by > 60% in eccentric. It is difficult to envision how these varied pleiotropic effects could result from loss of a single ion current. Rather, they suggest that the eccentric mutation affects a global regulatory system. Two plausible hypotheses are discussed.
65 schema:genre research_article
66 schema:inLanguage en
67 schema:isAccessibleForFree false
68 schema:isPartOf N66780bd429524647a942bc059b29cb76
69 N98c3b024496f4f249b3d092903a7b094
70 sg:journal.1012006
71 schema:name Inhibition of Mg2+ current by single-gene mutation in Paramecium
72 schema:pagination 203-212
73 schema:productId N26a218abc8a44a388b493f096e7cad6f
74 N5cca87a7532243888a042cc57ff6d6bb
75 Nc124ceb9dd324eee82275d75039e0b9d
76 Ne2a88b4ec514464bb77aaa6d0cdc7688
77 Nec116f08946f47d199d6671f29713be3
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051169866
79 https://doi.org/10.1007/bf00232624
80 schema:sdDatePublished 2019-04-15T09:03
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher N16e08c6ddb6442b5b092d339728e9e47
83 schema:url http://link.springer.com/10.1007%2FBF00232624
84 sgo:license sg:explorer/license/
85 sgo:sdDataset articles
86 rdf:type schema:ScholarlyArticle
87 N0f83e896e0844260ab3ecb3d9aa21253 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Phenotype
89 rdf:type schema:DefinedTerm
90 N16e08c6ddb6442b5b092d339728e9e47 schema:name Springer Nature - SN SciGraph project
91 rdf:type schema:Organization
92 N18bb5fc5ad6644aaacd644fec1bead71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Animals
94 rdf:type schema:DefinedTerm
95 N198255da2edb45b38c1331f0f5b8d97e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Cell Movement
97 rdf:type schema:DefinedTerm
98 N230b932b959843979fdecafd4f4f9c54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Potassium
100 rdf:type schema:DefinedTerm
101 N26a218abc8a44a388b493f096e7cad6f schema:name dimensions_id
102 schema:value pub.1051169866
103 rdf:type schema:PropertyValue
104 N2ab7f630ebd34618bf917ecbbf14afbb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Genes, Regulator
106 rdf:type schema:DefinedTerm
107 N2afcf41f2a694cd9acadd65d0f6a672c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Ion Channels
109 rdf:type schema:DefinedTerm
110 N4569ca5a45a149ed83ec180b65d6c0f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Sodium
112 rdf:type schema:DefinedTerm
113 N59a656dc55af467eaa6d96f2bae77361 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Paramecium tetraurelia
115 rdf:type schema:DefinedTerm
116 N5cca87a7532243888a042cc57ff6d6bb schema:name pubmed_id
117 schema:value 7538166
118 rdf:type schema:PropertyValue
119 N64bd431542cd486ca7d4516edfd347bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Mutation
121 rdf:type schema:DefinedTerm
122 N66780bd429524647a942bc059b29cb76 schema:volumeNumber 139
123 rdf:type schema:PublicationVolume
124 N98c3b024496f4f249b3d092903a7b094 schema:issueNumber 3
125 rdf:type schema:PublicationIssue
126 Na87c9b54e551471785e81a024c8c37b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Genes, Protozoan
128 rdf:type schema:DefinedTerm
129 Nb49f494d1ef74828a9dee8aa8eb5d143 rdf:first sg:person.01161131100.20
130 rdf:rest Nd33f0090e5204748b9cee1a6b285343f
131 Nb61a2a5becef46069eb9049ab3cb68ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Calcium
133 rdf:type schema:DefinedTerm
134 Nc124ceb9dd324eee82275d75039e0b9d schema:name nlm_unique_id
135 schema:value 0211301
136 rdf:type schema:PropertyValue
137 Nd33f0090e5204748b9cee1a6b285343f rdf:first sg:person.01360027630.66
138 rdf:rest rdf:nil
139 Nd4666210d7c241ab80cc0e2731f3f9c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Models, Biological
141 rdf:type schema:DefinedTerm
142 Ne2a88b4ec514464bb77aaa6d0cdc7688 schema:name doi
143 schema:value 10.1007/bf00232624
144 rdf:type schema:PropertyValue
145 Ne58e297942ef44a998fc7ee140a23d08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Genes, Recessive
147 rdf:type schema:DefinedTerm
148 Nec116f08946f47d199d6671f29713be3 schema:name readcube_id
149 schema:value f3c0f8eca4f1ce93203405bc79cba29edc9a22e724f3d95286bee9262a431321
150 rdf:type schema:PropertyValue
151 Nf7f6bfe4f07e4ce2a9e57efe8139c873 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Action Potentials
153 rdf:type schema:DefinedTerm
154 Nfa5104b5e601400a934805bab5b70019 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Magnesium
156 rdf:type schema:DefinedTerm
157 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
158 schema:name Biological Sciences
159 rdf:type schema:DefinedTerm
160 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
161 schema:name Biochemistry and Cell Biology
162 rdf:type schema:DefinedTerm
163 sg:grant.2508970 http://pending.schema.org/fundedItem sg:pub.10.1007/bf00232624
164 rdf:type schema:MonetaryGrant
165 sg:grant.2586054 http://pending.schema.org/fundedItem sg:pub.10.1007/bf00232624
166 rdf:type schema:MonetaryGrant
167 sg:journal.1012006 schema:issn 0022-2631
168 1432-1424
169 schema:name The Journal of Membrane Biology
170 rdf:type schema:Periodical
171 sg:person.01161131100.20 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
172 schema:familyName Preston
173 schema:givenName R. R.
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161131100.20
175 rdf:type schema:Person
176 sg:person.01360027630.66 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
177 schema:familyName Kung
178 schema:givenName C.
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360027630.66
180 rdf:type schema:Person
181 sg:pub.10.1007/978-3-642-70408-6_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050274307
182 https://doi.org/10.1007/978-3-642-70408-6_2
183 rdf:type schema:CreativeWork
184 sg:pub.10.1007/bf00196922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048686130
185 https://doi.org/10.1007/bf00196922
186 rdf:type schema:CreativeWork
187 sg:pub.10.1007/bf00196923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044988855
188 https://doi.org/10.1007/bf00196923
189 rdf:type schema:CreativeWork
190 sg:pub.10.1007/bf00392059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038227792
191 https://doi.org/10.1007/bf00392059
192 rdf:type schema:CreativeWork
193 sg:pub.10.1007/bf01869104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015204198
194 https://doi.org/10.1007/bf01869104
195 rdf:type schema:CreativeWork
196 sg:pub.10.1007/bf01869105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014557993
197 https://doi.org/10.1007/bf01869105
198 rdf:type schema:CreativeWork
199 sg:pub.10.1007/bf01869391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037245595
200 https://doi.org/10.1007/bf01869391
201 rdf:type schema:CreativeWork
202 sg:pub.10.1007/bf01870947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026557071
203 https://doi.org/10.1007/bf01870947
204 rdf:type schema:CreativeWork
205 sg:pub.10.1007/bf01871217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053221652
206 https://doi.org/10.1007/bf01871217
207 rdf:type schema:CreativeWork
208 sg:pub.10.1038/325156a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052080725
209 https://doi.org/10.1038/325156a0
210 rdf:type schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1079424431 schema:CreativeWork
212 https://app.dimensions.ai/details/publication/pub.1079673955 schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1080299631 schema:CreativeWork
214 https://app.dimensions.ai/details/publication/pub.1081563850 schema:CreativeWork
215 https://doi.org/10.1016/0006-2952(89)90272-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027994377
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/0022-5193(82)90130-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006260330
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/0092-8674(90)90250-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1050030558
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/0143-4160(92)90054-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1044762540
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/0165-6147(84)90372-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028944401
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/s0006-3495(89)82922-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052376539
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/s0006-3495(90)82626-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004079178
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1073/pnas.84.8.2560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016378662
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1073/pnas.86.8.2981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022854152
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1083/jcb.88.2.301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026843025
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1085/jgp.100.2.233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051812241
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1113/expphysiol.1990.sp003457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039795167
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1113/expphysiol.1990.sp003458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001717594
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1113/jphysiol.1980.sp013391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027138897
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1113/jphysiol.1983.sp014628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005138413
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1113/jphysiol.1984.sp015252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002682419
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1113/jphysiol.1985.sp015765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024136963
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1113/jphysiol.1987.sp016572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038982130
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1113/jphysiol.1989.sp017721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025607556
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1113/jphysiol.1991.sp018513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014672596
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1113/jphysiol.1991.sp018703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035639246
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1126/science.103199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062443464
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1126/science.2169650 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062525155
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1126/science.2218533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062527662
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1146/annurev.ph.52.030190.001353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047985615
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1146/annurev.ph.53.030191.001521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045069125
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1152/ajpcell.1989.257.1.c141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079313014
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1152/ajpcell.1991.260.6.c1158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078181863
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1152/ajpheart.1989.257.5.h1663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079075068
272 rdf:type schema:CreativeWork
273 https://www.grid.ac/institutes/grid.14003.36 schema:alternateName University of Wisconsin–Madison
274 schema:name Department of Genetics, University of Wisconsin-Madison, 53706, Madison, Wisconsin
275 Laboratory of Molecular Biology, University of Wisconsin-Madison, 53706, Madison, Wisconsin
276 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...