Glucocorticoid regulation of rRNA synthesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-05

AUTHORS

Pramod B. Mahajan, E. Aubrey Thompson

ABSTRACT

Glucocorticoids inhibit transcription of the genes encoding rRNA (rDNA) in P1798 lymphoma cells. This is due to a decrease in the amount or activity of a transcription factor, called TFIC. TFIC has been purified to apparent homogeneity and the properties of this protein have been investigated in detail. TFIC is tightly associated with RNA polymerase I. The data indicate that TFIC is a bona fide initiation factor that is required for formation of the first phosphodiester bond of nascent pre-rRNA. Extracts from dexamethasone-treated cells are devoid of this factor and cannot form initiated complexes in vitro. More... »

PAGES

195-200

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00229820

DOI

http://dx.doi.org/10.1007/bf00229820

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022183637

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1922000


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