Postnatal X-ray irradiation effects on glomerular layer of rat olfactory bulb: quantitative and immunocytochemical analysis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-01

AUTHORS

K. Kosaka, K. Taomoto, I. Nagatsu, C. W. Heizmann, W. Hunziker, T. Kosaka

ABSTRACT

In the rat olfactory bulb, the majority of interneurons in the glomerular layer (GL) are supposed to be generated during first postnatal week. Low and repeated doses of X-rays (200 rad x 4 and 200 rad x 6) were used during this period to impair the development of interneurons. The resulting effects of olfactory bulb neurons were examined stereologically and immunocytochemically in animals of 4 and 12 weeks of age. Quantitative analysis showed that, 1) the volume of the GL decreased to 55% (1200 rad) - 70% (800 rad) of control, 2) numerical cell densities in GL decreased to 40% (1200 rad) - 60% (800 rad) of control, thus resulting in 3) a decrease of the total cell number in GL to 20% (1200 rad) - 40% (800 rad) of control in irradiated olfactory bulbs of animals 4 weeks old. In comparison, mitral cells, which are generated prenatally, were much less affected (total cell number: 70-80% of control), indicating a selective loss of cells generated during the first postnatal week in GL. Effects on somata and processes immunoreactive for GABA, tyrosine hydroxylase (TH), calbindin D-28K and parvalbumin (PV) were examined in irradiated bulbs of both 4 and 12 week-old rats. All of these immunoreactive elements showed a drastic decrease in all layers. Semiquantitative analysis showed that in the GL, calbindin D-28K immunoreactive (calbindin D-28K(+)) neurons decreased more extensively than TH immunoreactive (TH(+)) and GABA-like immunoreactive (GABA(+)) neurons; that is, TH(+) and GABA(+) neurons decreased to 20% (1200 rad) - 40% (800 rad) of control, whereas calbindin D-28K(+) neurons decreased to 10% (1200 rad) - 30% (800 rad) of control in the GL of irradiated bulbs. These findings indicated that larger proportions of calbindin D-28K(+) neurons might be generated during the first postnatal week than those of GABA(+) and TH(+) neurons. Furthermore, in irradiated bulbs the proportion of GABA(-)TH(+) cells in TH(+) cells increased to about twice of control, and the estimated total numbers of GABA(-)TH(+) cells in irradiated rats were 95% (800 rad) and 40% (1200 rad) of control. These observations suggest that the majority of GABA(-)TH(+) neurons were less affected by X-ray irradiation during the first postnatal week and thus that they might be generated in the prenatal period. Since during the first 2 postnatal weeks, neurons showing GABA(-)TH(+) were not seen in GL (Kosaka et al. 1987a), the majority of GABA(-)TH(+) neurons in adult olfactory bulb were assumed to change their phenotype at some postnatal developmental period. More... »

PAGES

103-115

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00229261

DOI

http://dx.doi.org/10.1007/bf00229261

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034878445

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1355742


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals, Newborn", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calbindins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Catecholamines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interneurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Olfactory Bulb", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Inbred Strains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "S100 Calcium Binding Protein G", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tyrosine 3-Monooxygenase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "X-Rays", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "gamma-Aminobutyric Acid", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Kyushu University", 
          "id": "https://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "Department of Anatomy and Neurobiology, Faculty of Medicine, Kyushu University, Higashiku, 812, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kosaka", 
        "givenName": "K.", 
        "id": "sg:person.010034146171.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010034146171.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hyogo Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413699.0", 
          "name": [
            "Department of Neurosurgery, Hyogo Medical Center for Adults, Akashi, 673, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taomoto", 
        "givenName": "K.", 
        "id": "sg:person.01170473421.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170473421.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fujita Health University", 
          "id": "https://www.grid.ac/institutes/grid.256115.4", 
          "name": [
            "Department of Anatomy, Fujita Health University, 470-11, Toyoake, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagatsu", 
        "givenName": "I.", 
        "id": "sg:person.01030764465.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030764465.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Zurich", 
          "id": "https://www.grid.ac/institutes/grid.7400.3", 
          "name": [
            "Department of Pediatrics, Division of Clinical Chemistry, University of Z\u00fcrich, Steinwiesstr. 75, CH-8032, Z\u00fcrich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heizmann", 
        "givenName": "C. W.", 
        "id": "sg:person.01257747106.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257747106.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (Switzerland)", 
          "id": "https://www.grid.ac/institutes/grid.417570.0", 
          "name": [
            "Department PRTB, Pharma Research, F. Hoffmann-La Roche and Co. Ltd., CH-4002, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hunziker", 
        "givenName": "W.", 
        "id": "sg:person.01122711412.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122711412.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyushu University", 
          "id": "https://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "Department of Anatomy and Neurobiology, Faculty of Medicine, Kyushu University, Higashiku, 812, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kosaka", 
        "givenName": "T.", 
        "id": "sg:person.015435771211.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015435771211.45"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf01257970", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000817960", 
          "https://doi.org/10.1007/bf01257970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01257970", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000817960", 
          "https://doi.org/10.1007/bf01257970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(90)90091-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002075598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(90)90091-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002075598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2818.1984.tb02501.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003830806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(83)90206-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004703493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(83)90206-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004703493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10520297209116485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005060591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(85)90408-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005996882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(85)90408-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005996882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(88)90983-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009176832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(88)90983-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009176832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00239197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009328192", 
          "https://doi.org/10.1007/bf00239197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00239197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009328192", 
          "https://doi.org/10.1007/bf00239197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(78)90699-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013694652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(78)90699-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013694652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2818.1986.tb02764.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016136529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-0270(86)90012-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016685751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-0270(86)90012-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016685751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(87)91090-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017364130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(87)91090-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017364130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(77)90211-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021258785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(77)90211-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021258785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4886(75)90231-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021264625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00236215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021655912", 
          "https://doi.org/10.1007/bf00236215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00236215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021655912", 
          "https://doi.org/10.1007/bf00236215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.902140407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026418785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0091-6773(78)90983-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028834545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/29.4.6166661", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029463505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/29.4.6166661", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029463505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00493380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030525411", 
          "https://doi.org/10.1007/bf00493380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00493380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030525411", 
          "https://doi.org/10.1007/bf00493380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00248757", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031154592", 
          "https://doi.org/10.1007/bf00248757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00248757", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031154592", 
          "https://doi.org/10.1007/bf00248757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(87)90121-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032806933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(87)90121-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032806933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.902390408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035826864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.902390408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035826864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(86)90112-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036019066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(86)90112-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036019066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2818.1987.tb02837.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036159621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/25.12.336785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036698919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/25.12.336785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036698919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.901630102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037432821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(85)91172-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038897235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(85)91172-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038897235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4886(68)90019-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042831711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(87)90075-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042999613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(87)90075-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042999613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(77)90597-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044238246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(77)90597-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044238246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(82)90804-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045558221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(82)90804-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045558221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1990.tb04879.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046823585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(82)90050-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052935607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(82)90050-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052935607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.1958.38.3.337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075840235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079444335", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079667489", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080134929", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080134930", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080824357", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1992-01", 
    "datePublishedReg": "1992-01-01", 
    "description": "In the rat olfactory bulb, the majority of interneurons in the glomerular layer (GL) are supposed to be generated during first postnatal week. Low and repeated doses of X-rays (200 rad x 4 and 200 rad x 6) were used during this period to impair the development of interneurons. The resulting effects of olfactory bulb neurons were examined stereologically and immunocytochemically in animals of 4 and 12 weeks of age. Quantitative analysis showed that, 1) the volume of the GL decreased to 55% (1200 rad) - 70% (800 rad) of control, 2) numerical cell densities in GL decreased to 40% (1200 rad) - 60% (800 rad) of control, thus resulting in 3) a decrease of the total cell number in GL to 20% (1200 rad) - 40% (800 rad) of control in irradiated olfactory bulbs of animals 4 weeks old. In comparison, mitral cells, which are generated prenatally, were much less affected (total cell number: 70-80% of control), indicating a selective loss of cells generated during the first postnatal week in GL. Effects on somata and processes immunoreactive for GABA, tyrosine hydroxylase (TH), calbindin D-28K and parvalbumin (PV) were examined in irradiated bulbs of both 4 and 12 week-old rats. All of these immunoreactive elements showed a drastic decrease in all layers. Semiquantitative analysis showed that in the GL, calbindin D-28K immunoreactive (calbindin D-28K(+)) neurons decreased more extensively than TH immunoreactive (TH(+)) and GABA-like immunoreactive (GABA(+)) neurons; that is, TH(+) and GABA(+) neurons decreased to 20% (1200 rad) - 40% (800 rad) of control, whereas calbindin D-28K(+) neurons decreased to 10% (1200 rad) - 30% (800 rad) of control in the GL of irradiated bulbs. These findings indicated that larger proportions of calbindin D-28K(+) neurons might be generated during the first postnatal week than those of GABA(+) and TH(+) neurons. Furthermore, in irradiated bulbs the proportion of GABA(-)TH(+) cells in TH(+) cells increased to about twice of control, and the estimated total numbers of GABA(-)TH(+) cells in irradiated rats were 95% (800 rad) and 40% (1200 rad) of control. These observations suggest that the majority of GABA(-)TH(+) neurons were less affected by X-ray irradiation during the first postnatal week and thus that they might be generated in the prenatal period. Since during the first 2 postnatal weeks, neurons showing GABA(-)TH(+) were not seen in GL (Kosaka et al. 1987a), the majority of GABA(-)TH(+) neurons in adult olfactory bulb were assumed to change their phenotype at some postnatal developmental period.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00229261", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1005581", 
        "issn": [
          "0014-4819", 
          "1432-1106"
        ], 
        "name": "Experimental Brain Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "90"
      }
    ], 
    "name": "Postnatal X-ray irradiation effects on glomerular layer of rat olfactory bulb: quantitative and immunocytochemical analysis", 
    "pagination": "103-115", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00229261"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a625c8b41393f9f2254f39b0d63a9a3b1427d6223fd2be35f8d173c47fb68002"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1034878445"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0043312"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "1355742"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00229261", 
      "https://app.dimensions.ai/details/publication/pub.1034878445"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T09:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000375_0000000375/records_91441_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2FBF00229261"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00229261'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00229261'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00229261'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00229261'


 

This table displays all metadata directly associated to this object as RDF triples.

285 TRIPLES      21 PREDICATES      81 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00229261 schema:about N05f05f5eabbe45f8b7a18387d78aabba
2 N38bd6a6217c146899341dd444b550f12
3 N3d0039919ba0433584a68870b599b129
4 N3d960f3327e74b7e89c0d365ccd4062b
5 N429a8b72f025430a8d6010dd72e6c23f
6 N6cc34d416b5048bb896d8852769886e5
7 N92900811e1924c7bbe3ec5597911307c
8 N9cc7e09cf88047e582a5e8ac3b86726d
9 Nae2dabb160aa4dbc8f9bc1a56e214519
10 Nb2f397e39f1d44379b9a71395dcbf8c9
11 Ncb0a710f248f4b078d377d6d9b8d7f69
12 Ncf190dfe7d7d401786b57a97d0546831
13 Nfe3abddbedb34f10ae7c6d6ad7929bef
14 anzsrc-for:11
15 anzsrc-for:1109
16 schema:author N78d32daf7dcc4ae3ae1923ff58552080
17 schema:citation sg:pub.10.1007/bf00236215
18 sg:pub.10.1007/bf00239197
19 sg:pub.10.1007/bf00248757
20 sg:pub.10.1007/bf00493380
21 sg:pub.10.1007/bf01257970
22 https://app.dimensions.ai/details/publication/pub.1079444335
23 https://app.dimensions.ai/details/publication/pub.1079667489
24 https://app.dimensions.ai/details/publication/pub.1080134929
25 https://app.dimensions.ai/details/publication/pub.1080134930
26 https://app.dimensions.ai/details/publication/pub.1080824357
27 https://doi.org/10.1002/cne.901630102
28 https://doi.org/10.1002/cne.902140407
29 https://doi.org/10.1002/cne.902390408
30 https://doi.org/10.1016/0006-8993(77)90211-6
31 https://doi.org/10.1016/0006-8993(77)90597-2
32 https://doi.org/10.1016/0006-8993(78)90699-6
33 https://doi.org/10.1016/0006-8993(82)90804-6
34 https://doi.org/10.1016/0006-8993(85)91172-2
35 https://doi.org/10.1016/0006-8993(87)90075-8
36 https://doi.org/10.1016/0006-8993(87)91090-0
37 https://doi.org/10.1016/0006-8993(88)90983-3
38 https://doi.org/10.1016/0014-4886(68)90019-8
39 https://doi.org/10.1016/0014-4886(75)90231-9
40 https://doi.org/10.1016/0165-0270(86)90012-9
41 https://doi.org/10.1016/0304-3940(85)90408-2
42 https://doi.org/10.1016/0306-4522(82)90050-1
43 https://doi.org/10.1016/0306-4522(83)90206-3
44 https://doi.org/10.1016/0306-4522(86)90112-0
45 https://doi.org/10.1016/0306-4522(87)90121-7
46 https://doi.org/10.1016/0306-4522(90)90091-h
47 https://doi.org/10.1016/s0091-6773(78)90983-5
48 https://doi.org/10.1111/j.1365-2818.1984.tb02501.x
49 https://doi.org/10.1111/j.1365-2818.1986.tb02764.x
50 https://doi.org/10.1111/j.1365-2818.1987.tb02837.x
51 https://doi.org/10.1111/j.1471-4159.1990.tb04879.x
52 https://doi.org/10.1152/physrev.1958.38.3.337
53 https://doi.org/10.1177/25.12.336785
54 https://doi.org/10.1177/29.4.6166661
55 https://doi.org/10.3109/10520297209116485
56 schema:datePublished 1992-01
57 schema:datePublishedReg 1992-01-01
58 schema:description In the rat olfactory bulb, the majority of interneurons in the glomerular layer (GL) are supposed to be generated during first postnatal week. Low and repeated doses of X-rays (200 rad x 4 and 200 rad x 6) were used during this period to impair the development of interneurons. The resulting effects of olfactory bulb neurons were examined stereologically and immunocytochemically in animals of 4 and 12 weeks of age. Quantitative analysis showed that, 1) the volume of the GL decreased to 55% (1200 rad) - 70% (800 rad) of control, 2) numerical cell densities in GL decreased to 40% (1200 rad) - 60% (800 rad) of control, thus resulting in 3) a decrease of the total cell number in GL to 20% (1200 rad) - 40% (800 rad) of control in irradiated olfactory bulbs of animals 4 weeks old. In comparison, mitral cells, which are generated prenatally, were much less affected (total cell number: 70-80% of control), indicating a selective loss of cells generated during the first postnatal week in GL. Effects on somata and processes immunoreactive for GABA, tyrosine hydroxylase (TH), calbindin D-28K and parvalbumin (PV) were examined in irradiated bulbs of both 4 and 12 week-old rats. All of these immunoreactive elements showed a drastic decrease in all layers. Semiquantitative analysis showed that in the GL, calbindin D-28K immunoreactive (calbindin D-28K(+)) neurons decreased more extensively than TH immunoreactive (TH(+)) and GABA-like immunoreactive (GABA(+)) neurons; that is, TH(+) and GABA(+) neurons decreased to 20% (1200 rad) - 40% (800 rad) of control, whereas calbindin D-28K(+) neurons decreased to 10% (1200 rad) - 30% (800 rad) of control in the GL of irradiated bulbs. These findings indicated that larger proportions of calbindin D-28K(+) neurons might be generated during the first postnatal week than those of GABA(+) and TH(+) neurons. Furthermore, in irradiated bulbs the proportion of GABA(-)TH(+) cells in TH(+) cells increased to about twice of control, and the estimated total numbers of GABA(-)TH(+) cells in irradiated rats were 95% (800 rad) and 40% (1200 rad) of control. These observations suggest that the majority of GABA(-)TH(+) neurons were less affected by X-ray irradiation during the first postnatal week and thus that they might be generated in the prenatal period. Since during the first 2 postnatal weeks, neurons showing GABA(-)TH(+) were not seen in GL (Kosaka et al. 1987a), the majority of GABA(-)TH(+) neurons in adult olfactory bulb were assumed to change their phenotype at some postnatal developmental period.
59 schema:genre research_article
60 schema:inLanguage en
61 schema:isAccessibleForFree false
62 schema:isPartOf N51f99f205f514421b6c8cbfdcd5e4e02
63 Nc562b28df10b4a42bc077616b3563fe5
64 sg:journal.1005581
65 schema:name Postnatal X-ray irradiation effects on glomerular layer of rat olfactory bulb: quantitative and immunocytochemical analysis
66 schema:pagination 103-115
67 schema:productId N0602493d792941b3a6ca97fdee85efe8
68 N0b6445d3a0bf4983941a246f3b0d2db2
69 N0f4902e569d4444fbfff0d1572742d07
70 Nc52761d4fd064513a7959d9170016161
71 Nd3505820c60d40a6abab203c460db5e4
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034878445
73 https://doi.org/10.1007/bf00229261
74 schema:sdDatePublished 2019-04-15T09:00
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher N8d2ac62a7d844588a51f0b03ab4a9e6f
77 schema:url http://link.springer.com/10.1007%2FBF00229261
78 sgo:license sg:explorer/license/
79 sgo:sdDataset articles
80 rdf:type schema:ScholarlyArticle
81 N05f05f5eabbe45f8b7a18387d78aabba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Animals
83 rdf:type schema:DefinedTerm
84 N0602493d792941b3a6ca97fdee85efe8 schema:name dimensions_id
85 schema:value pub.1034878445
86 rdf:type schema:PropertyValue
87 N0b6445d3a0bf4983941a246f3b0d2db2 schema:name pubmed_id
88 schema:value 1355742
89 rdf:type schema:PropertyValue
90 N0d2d8a2cef064bddaebc0155eb6b4b8a rdf:first sg:person.01170473421.07
91 rdf:rest N202cdfa69991455cb63c3c26e3988741
92 N0f4902e569d4444fbfff0d1572742d07 schema:name readcube_id
93 schema:value a625c8b41393f9f2254f39b0d63a9a3b1427d6223fd2be35f8d173c47fb68002
94 rdf:type schema:PropertyValue
95 N1eef95d3a67d4259abce2ac71c8aa267 rdf:first sg:person.01122711412.64
96 rdf:rest N91498d6bca004d2d81a77b5b230cba6d
97 N202cdfa69991455cb63c3c26e3988741 rdf:first sg:person.01030764465.69
98 rdf:rest Nf5c909a63e674f82bcb74d0d53b522d4
99 N38bd6a6217c146899341dd444b550f12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Interneurons
101 rdf:type schema:DefinedTerm
102 N3d0039919ba0433584a68870b599b129 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name S100 Calcium Binding Protein G
104 rdf:type schema:DefinedTerm
105 N3d960f3327e74b7e89c0d365ccd4062b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name gamma-Aminobutyric Acid
107 rdf:type schema:DefinedTerm
108 N429a8b72f025430a8d6010dd72e6c23f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Animals, Newborn
110 rdf:type schema:DefinedTerm
111 N51f99f205f514421b6c8cbfdcd5e4e02 schema:issueNumber 1
112 rdf:type schema:PublicationIssue
113 N6cc34d416b5048bb896d8852769886e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Rats
115 rdf:type schema:DefinedTerm
116 N78d32daf7dcc4ae3ae1923ff58552080 rdf:first sg:person.010034146171.48
117 rdf:rest N0d2d8a2cef064bddaebc0155eb6b4b8a
118 N8d2ac62a7d844588a51f0b03ab4a9e6f schema:name Springer Nature - SN SciGraph project
119 rdf:type schema:Organization
120 N91498d6bca004d2d81a77b5b230cba6d rdf:first sg:person.015435771211.45
121 rdf:rest rdf:nil
122 N92900811e1924c7bbe3ec5597911307c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Catecholamines
124 rdf:type schema:DefinedTerm
125 N9cc7e09cf88047e582a5e8ac3b86726d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Rats, Inbred Strains
127 rdf:type schema:DefinedTerm
128 Nae2dabb160aa4dbc8f9bc1a56e214519 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Tyrosine 3-Monooxygenase
130 rdf:type schema:DefinedTerm
131 Nb2f397e39f1d44379b9a71395dcbf8c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Olfactory Bulb
133 rdf:type schema:DefinedTerm
134 Nc52761d4fd064513a7959d9170016161 schema:name doi
135 schema:value 10.1007/bf00229261
136 rdf:type schema:PropertyValue
137 Nc562b28df10b4a42bc077616b3563fe5 schema:volumeNumber 90
138 rdf:type schema:PublicationVolume
139 Ncb0a710f248f4b078d377d6d9b8d7f69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Calbindins
141 rdf:type schema:DefinedTerm
142 Ncf190dfe7d7d401786b57a97d0546831 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name X-Rays
144 rdf:type schema:DefinedTerm
145 Nd3505820c60d40a6abab203c460db5e4 schema:name nlm_unique_id
146 schema:value 0043312
147 rdf:type schema:PropertyValue
148 Nf5c909a63e674f82bcb74d0d53b522d4 rdf:first sg:person.01257747106.47
149 rdf:rest N1eef95d3a67d4259abce2ac71c8aa267
150 Nfe3abddbedb34f10ae7c6d6ad7929bef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Immunohistochemistry
152 rdf:type schema:DefinedTerm
153 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
154 schema:name Medical and Health Sciences
155 rdf:type schema:DefinedTerm
156 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
157 schema:name Neurosciences
158 rdf:type schema:DefinedTerm
159 sg:journal.1005581 schema:issn 0014-4819
160 1432-1106
161 schema:name Experimental Brain Research
162 rdf:type schema:Periodical
163 sg:person.010034146171.48 schema:affiliation https://www.grid.ac/institutes/grid.177174.3
164 schema:familyName Kosaka
165 schema:givenName K.
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010034146171.48
167 rdf:type schema:Person
168 sg:person.01030764465.69 schema:affiliation https://www.grid.ac/institutes/grid.256115.4
169 schema:familyName Nagatsu
170 schema:givenName I.
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030764465.69
172 rdf:type schema:Person
173 sg:person.01122711412.64 schema:affiliation https://www.grid.ac/institutes/grid.417570.0
174 schema:familyName Hunziker
175 schema:givenName W.
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122711412.64
177 rdf:type schema:Person
178 sg:person.01170473421.07 schema:affiliation https://www.grid.ac/institutes/grid.413699.0
179 schema:familyName Taomoto
180 schema:givenName K.
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170473421.07
182 rdf:type schema:Person
183 sg:person.01257747106.47 schema:affiliation https://www.grid.ac/institutes/grid.7400.3
184 schema:familyName Heizmann
185 schema:givenName C. W.
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257747106.47
187 rdf:type schema:Person
188 sg:person.015435771211.45 schema:affiliation https://www.grid.ac/institutes/grid.177174.3
189 schema:familyName Kosaka
190 schema:givenName T.
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015435771211.45
192 rdf:type schema:Person
193 sg:pub.10.1007/bf00236215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021655912
194 https://doi.org/10.1007/bf00236215
195 rdf:type schema:CreativeWork
196 sg:pub.10.1007/bf00239197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009328192
197 https://doi.org/10.1007/bf00239197
198 rdf:type schema:CreativeWork
199 sg:pub.10.1007/bf00248757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031154592
200 https://doi.org/10.1007/bf00248757
201 rdf:type schema:CreativeWork
202 sg:pub.10.1007/bf00493380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030525411
203 https://doi.org/10.1007/bf00493380
204 rdf:type schema:CreativeWork
205 sg:pub.10.1007/bf01257970 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000817960
206 https://doi.org/10.1007/bf01257970
207 rdf:type schema:CreativeWork
208 https://app.dimensions.ai/details/publication/pub.1079444335 schema:CreativeWork
209 https://app.dimensions.ai/details/publication/pub.1079667489 schema:CreativeWork
210 https://app.dimensions.ai/details/publication/pub.1080134929 schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1080134930 schema:CreativeWork
212 https://app.dimensions.ai/details/publication/pub.1080824357 schema:CreativeWork
213 https://doi.org/10.1002/cne.901630102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037432821
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1002/cne.902140407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026418785
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1002/cne.902390408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035826864
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/0006-8993(77)90211-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021258785
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/0006-8993(77)90597-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044238246
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/0006-8993(78)90699-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013694652
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/0006-8993(82)90804-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045558221
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/0006-8993(85)91172-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038897235
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/0006-8993(87)90075-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042999613
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/0006-8993(87)91090-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017364130
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/0006-8993(88)90983-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009176832
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/0014-4886(68)90019-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042831711
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/0014-4886(75)90231-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021264625
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/0165-0270(86)90012-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016685751
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/0304-3940(85)90408-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005996882
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/0306-4522(82)90050-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052935607
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/0306-4522(83)90206-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004703493
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/0306-4522(86)90112-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036019066
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/0306-4522(87)90121-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032806933
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/0306-4522(90)90091-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1002075598
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s0091-6773(78)90983-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028834545
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1111/j.1365-2818.1984.tb02501.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003830806
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1111/j.1365-2818.1986.tb02764.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016136529
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1111/j.1365-2818.1987.tb02837.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036159621
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1111/j.1471-4159.1990.tb04879.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046823585
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1152/physrev.1958.38.3.337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075840235
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1177/25.12.336785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036698919
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1177/29.4.6166661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029463505
268 rdf:type schema:CreativeWork
269 https://doi.org/10.3109/10520297209116485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005060591
270 rdf:type schema:CreativeWork
271 https://www.grid.ac/institutes/grid.177174.3 schema:alternateName Kyushu University
272 schema:name Department of Anatomy and Neurobiology, Faculty of Medicine, Kyushu University, Higashiku, 812, Fukuoka, Japan
273 rdf:type schema:Organization
274 https://www.grid.ac/institutes/grid.256115.4 schema:alternateName Fujita Health University
275 schema:name Department of Anatomy, Fujita Health University, 470-11, Toyoake, Japan
276 rdf:type schema:Organization
277 https://www.grid.ac/institutes/grid.413699.0 schema:alternateName Hyogo Medical Center
278 schema:name Department of Neurosurgery, Hyogo Medical Center for Adults, Akashi, 673, Hyogo, Japan
279 rdf:type schema:Organization
280 https://www.grid.ac/institutes/grid.417570.0 schema:alternateName Roche (Switzerland)
281 schema:name Department PRTB, Pharma Research, F. Hoffmann-La Roche and Co. Ltd., CH-4002, Basel, Switzerland
282 rdf:type schema:Organization
283 https://www.grid.ac/institutes/grid.7400.3 schema:alternateName University of Zurich
284 schema:name Department of Pediatrics, Division of Clinical Chemistry, University of Zürich, Steinwiesstr. 75, CH-8032, Zürich, Switzerland
285 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...