Intranuclear inclusions in paramyxovirus-induced encephalitis: evidence for altered nuclear body differentiation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-09

AUTHORS

M. Oglesbee

ABSTRACT

Intranuclear inclusion bodies (INB) are frequently encountered in viral infections, where they are thought to be accumulations of viral particles. However, for RNA viruses replicating in the cytoplasm, this compartmentalization represents a paradox not consistent with the viral replication cycle. To define the basis for intranuclear paramyxoviral inclusion bodies in astrocytes, natural cases of canine distemper virus subacute encephalitis were examined by light and transmission electron microscopy, and by quantitative confocal immunofluorescence microscopy. Although INB were viral antigen positive, they were not composed of structurally recognizable paramyxoviral nucleocapsids. The structural basis for the INB was instead viral antigen-associated forms of nucleolar development known as nuclear bodies. Three variants of the light microscopic Cowdry type A INB were complex nuclear bodies, giant beaded nuclear bodies (sphaeridia), and nuclear body-associated granulofilamentous matrices. In the latter, the granulofilamentous matrix frequently filled the nucleus, resulting in a fourth morphological INB variant, and was associated with morphological evidence of nuclear degeneration. These findings suggest a novel mechanism of virus-induced cytopathology whereby intranuclear viral protein exerts deleterious effects upon nucleolar differentiation in infected cells and hence altered host cell RNA metabolism. More... »

PAGES

407-415

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00227668

DOI

http://dx.doi.org/10.1007/bf00227668

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034431220

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1332364


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Astrocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Nucleus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Distemper", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Distemper Virus, Canine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dogs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inclusion Bodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Electron", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Fluorescence", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The Ohio State University", 
          "id": "https://www.grid.ac/institutes/grid.261331.4", 
          "name": [
            "The Department of Veterinary Pathobiology, The Ohio State University, 1925 Coffey Road, 43210, Columbus, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oglesbee", 
        "givenName": "M.", 
        "id": "sg:person.01217137154.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217137154.39"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0306-4522(91)90124-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003210311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(91)90124-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003210311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5320(80)90020-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003344744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000145131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005047153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5320(72)80022-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005835383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ar.1092050203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005907363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-3806(85)90185-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008427249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-3806(85)90185-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008427249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0021-9975(87)90022-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008760673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5320(69)90085-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015687581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.17.2.423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018473924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0922-3371(88)90051-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024426540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0922-3371(88)90051-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024426540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01315672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024579225", 
          "https://doi.org/10.1007/bf01315672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01315672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024579225", 
          "https://doi.org/10.1007/bf01315672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(73)90527-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026519305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(73)90527-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026519305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0248-4900(88)90007-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029916838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00684475", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030413215", 
          "https://doi.org/10.1007/bf00684475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00684475", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030413215", 
          "https://doi.org/10.1007/bf00684475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0042-6822(78)90357-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032572756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-0934(86)90022-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032821480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-0934(86)90022-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032821480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.104.5.1353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033238289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1989.135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034335378", 
          "https://doi.org/10.1038/ki.1989.135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/ki.1989.135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034335378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0042-6822(85)90132-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035536604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01311011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036330795", 
          "https://doi.org/10.1007/bf01311011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01311011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036330795", 
          "https://doi.org/10.1007/bf01311011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5320(71)80119-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037433104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/01913129009050870", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039304893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-0934(89)90040-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041576588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-0934(89)90040-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041576588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5320(67)80074-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041697360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-0934(86)90016-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042218393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-0934(86)90016-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042218393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.106.3.575", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053667085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.1990.6.1131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059223084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/0022-1317-67-10-2153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060355892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/0022-1317-71-12-2847", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060357403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1768-322x.1984.tb00220.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061958541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3872478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062622032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem-34-2-257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064307680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077652372", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077847950", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078050608", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078310187", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078653494", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079413911", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079815111", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080102575", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080129749", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080717433", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080756185", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081098414", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081354861", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081467380", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081857170", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1992-09", 
    "datePublishedReg": "1992-09-01", 
    "description": "Intranuclear inclusion bodies (INB) are frequently encountered in viral infections, where they are thought to be accumulations of viral particles. However, for RNA viruses replicating in the cytoplasm, this compartmentalization represents a paradox not consistent with the viral replication cycle. To define the basis for intranuclear paramyxoviral inclusion bodies in astrocytes, natural cases of canine distemper virus subacute encephalitis were examined by light and transmission electron microscopy, and by quantitative confocal immunofluorescence microscopy. Although INB were viral antigen positive, they were not composed of structurally recognizable paramyxoviral nucleocapsids. The structural basis for the INB was instead viral antigen-associated forms of nucleolar development known as nuclear bodies. Three variants of the light microscopic Cowdry type A INB were complex nuclear bodies, giant beaded nuclear bodies (sphaeridia), and nuclear body-associated granulofilamentous matrices. In the latter, the granulofilamentous matrix frequently filled the nucleus, resulting in a fourth morphological INB variant, and was associated with morphological evidence of nuclear degeneration. These findings suggest a novel mechanism of virus-induced cytopathology whereby intranuclear viral protein exerts deleterious effects upon nucleolar differentiation in infected cells and hence altered host cell RNA metabolism.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00227668", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1019073", 
        "issn": [
          "0001-6322", 
          "1432-0533"
        ], 
        "name": "Acta Neuropathologica", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "84"
      }
    ], 
    "name": "Intranuclear inclusions in paramyxovirus-induced encephalitis: evidence for altered nuclear body differentiation", 
    "pagination": "407-415", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00227668"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a40431311ee62757de4fce0c96a7f2216a6701ededdaabce7f5725d818b18d99"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1034431220"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0412041"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "1332364"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00227668", 
      "https://app.dimensions.ai/details/publication/pub.1034431220"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T09:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000375_0000000375/records_91466_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF00227668"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00227668'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00227668'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00227668'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00227668'


 

This table displays all metadata directly associated to this object as RDF triples.

238 TRIPLES      21 PREDICATES      86 URIs      30 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00227668 schema:about N47dd612c7e704260a2912c24fbabdb8a
2 N978a499c05b54b3da4065dc484b2adad
3 N9982adec7078412192e0a07518c18fd8
4 Nc433db30e56e43a3b007a6c88afd68b7
5 Nd8dd0bd490aa4bbf96530e8bf977eaef
6 Nd9422e9f3a90421fa60be3eacefda1d7
7 Ndf7be7a2bf914f689c5377a1674dc367
8 Nf0245d7b60524ceb887a5085961fa4d8
9 Nfddf40f542244bf3981fb2f330b972e0
10 anzsrc-for:11
11 anzsrc-for:1108
12 schema:author N59dcfec4b7e148f9bf02ed2dcf9bb014
13 schema:citation sg:pub.10.1007/bf00684475
14 sg:pub.10.1007/bf01311011
15 sg:pub.10.1007/bf01315672
16 sg:pub.10.1038/ki.1989.135
17 https://app.dimensions.ai/details/publication/pub.1077652372
18 https://app.dimensions.ai/details/publication/pub.1077847950
19 https://app.dimensions.ai/details/publication/pub.1078050608
20 https://app.dimensions.ai/details/publication/pub.1078310187
21 https://app.dimensions.ai/details/publication/pub.1078653494
22 https://app.dimensions.ai/details/publication/pub.1079413911
23 https://app.dimensions.ai/details/publication/pub.1079815111
24 https://app.dimensions.ai/details/publication/pub.1080102575
25 https://app.dimensions.ai/details/publication/pub.1080129749
26 https://app.dimensions.ai/details/publication/pub.1080717433
27 https://app.dimensions.ai/details/publication/pub.1080756185
28 https://app.dimensions.ai/details/publication/pub.1081098414
29 https://app.dimensions.ai/details/publication/pub.1081354861
30 https://app.dimensions.ai/details/publication/pub.1081467380
31 https://app.dimensions.ai/details/publication/pub.1081857170
32 https://doi.org/10.1002/ar.1092050203
33 https://doi.org/10.1016/0006-8993(73)90527-1
34 https://doi.org/10.1016/0021-9975(87)90022-3
35 https://doi.org/10.1016/0042-6822(78)90357-4
36 https://doi.org/10.1016/0042-6822(85)90132-1
37 https://doi.org/10.1016/0165-3806(85)90185-3
38 https://doi.org/10.1016/0166-0934(86)90016-9
39 https://doi.org/10.1016/0166-0934(86)90022-4
40 https://doi.org/10.1016/0166-0934(89)90040-2
41 https://doi.org/10.1016/0248-4900(88)90007-x
42 https://doi.org/10.1016/0306-4522(91)90124-7
43 https://doi.org/10.1016/0922-3371(88)90051-2
44 https://doi.org/10.1016/s0022-5320(67)80074-1
45 https://doi.org/10.1016/s0022-5320(69)90085-9
46 https://doi.org/10.1016/s0022-5320(71)80119-3
47 https://doi.org/10.1016/s0022-5320(72)80022-4
48 https://doi.org/10.1016/s0022-5320(80)90020-9
49 https://doi.org/10.1038/ki.1989.135
50 https://doi.org/10.1083/jcb.104.5.1353
51 https://doi.org/10.1083/jcb.106.3.575
52 https://doi.org/10.1083/jcb.17.2.423
53 https://doi.org/10.1089/aid.1990.6.1131
54 https://doi.org/10.1099/0022-1317-67-10-2153
55 https://doi.org/10.1099/0022-1317-71-12-2847
56 https://doi.org/10.1111/j.1768-322x.1984.tb00220.x
57 https://doi.org/10.1126/science.3872478
58 https://doi.org/10.1159/000145131
59 https://doi.org/10.1210/jcem-34-2-257
60 https://doi.org/10.3109/01913129009050870
61 schema:datePublished 1992-09
62 schema:datePublishedReg 1992-09-01
63 schema:description Intranuclear inclusion bodies (INB) are frequently encountered in viral infections, where they are thought to be accumulations of viral particles. However, for RNA viruses replicating in the cytoplasm, this compartmentalization represents a paradox not consistent with the viral replication cycle. To define the basis for intranuclear paramyxoviral inclusion bodies in astrocytes, natural cases of canine distemper virus subacute encephalitis were examined by light and transmission electron microscopy, and by quantitative confocal immunofluorescence microscopy. Although INB were viral antigen positive, they were not composed of structurally recognizable paramyxoviral nucleocapsids. The structural basis for the INB was instead viral antigen-associated forms of nucleolar development known as nuclear bodies. Three variants of the light microscopic Cowdry type A INB were complex nuclear bodies, giant beaded nuclear bodies (sphaeridia), and nuclear body-associated granulofilamentous matrices. In the latter, the granulofilamentous matrix frequently filled the nucleus, resulting in a fourth morphological INB variant, and was associated with morphological evidence of nuclear degeneration. These findings suggest a novel mechanism of virus-induced cytopathology whereby intranuclear viral protein exerts deleterious effects upon nucleolar differentiation in infected cells and hence altered host cell RNA metabolism.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree false
67 schema:isPartOf N1309a1c7864947e88e368e0a85693f5e
68 N7c1d5e1ea31e4f32b75b2071a15b81c6
69 sg:journal.1019073
70 schema:name Intranuclear inclusions in paramyxovirus-induced encephalitis: evidence for altered nuclear body differentiation
71 schema:pagination 407-415
72 schema:productId N4eaa57f47e5a4dac8a7c34df240baf33
73 N960d810b2e0b48fa85a0ddb78c91e38f
74 N9cb41eb53bc647e19cbf5853cdb5e07c
75 Nc8a936ca5ba740388fd52be76b485e69
76 Ne21ce8a2baf842ba8c0769a5132bdc36
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034431220
78 https://doi.org/10.1007/bf00227668
79 schema:sdDatePublished 2019-04-15T09:04
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher N375dbe0102884f2e922eeb53cc99faa1
82 schema:url http://link.springer.com/10.1007/BF00227668
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N1309a1c7864947e88e368e0a85693f5e schema:volumeNumber 84
87 rdf:type schema:PublicationVolume
88 N375dbe0102884f2e922eeb53cc99faa1 schema:name Springer Nature - SN SciGraph project
89 rdf:type schema:Organization
90 N47dd612c7e704260a2912c24fbabdb8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Distemper Virus, Canine
92 rdf:type schema:DefinedTerm
93 N4eaa57f47e5a4dac8a7c34df240baf33 schema:name nlm_unique_id
94 schema:value 0412041
95 rdf:type schema:PropertyValue
96 N59dcfec4b7e148f9bf02ed2dcf9bb014 rdf:first sg:person.01217137154.39
97 rdf:rest rdf:nil
98 N7c1d5e1ea31e4f32b75b2071a15b81c6 schema:issueNumber 4
99 rdf:type schema:PublicationIssue
100 N960d810b2e0b48fa85a0ddb78c91e38f schema:name dimensions_id
101 schema:value pub.1034431220
102 rdf:type schema:PropertyValue
103 N978a499c05b54b3da4065dc484b2adad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Inclusion Bodies
105 rdf:type schema:DefinedTerm
106 N9982adec7078412192e0a07518c18fd8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Microscopy, Fluorescence
108 rdf:type schema:DefinedTerm
109 N9cb41eb53bc647e19cbf5853cdb5e07c schema:name doi
110 schema:value 10.1007/bf00227668
111 rdf:type schema:PropertyValue
112 Nc433db30e56e43a3b007a6c88afd68b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Dogs
114 rdf:type schema:DefinedTerm
115 Nc8a936ca5ba740388fd52be76b485e69 schema:name readcube_id
116 schema:value a40431311ee62757de4fce0c96a7f2216a6701ededdaabce7f5725d818b18d99
117 rdf:type schema:PropertyValue
118 Nd8dd0bd490aa4bbf96530e8bf977eaef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Animals
120 rdf:type schema:DefinedTerm
121 Nd9422e9f3a90421fa60be3eacefda1d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Distemper
123 rdf:type schema:DefinedTerm
124 Ndf7be7a2bf914f689c5377a1674dc367 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Astrocytes
126 rdf:type schema:DefinedTerm
127 Ne21ce8a2baf842ba8c0769a5132bdc36 schema:name pubmed_id
128 schema:value 1332364
129 rdf:type schema:PropertyValue
130 Nf0245d7b60524ceb887a5085961fa4d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Microscopy, Electron
132 rdf:type schema:DefinedTerm
133 Nfddf40f542244bf3981fb2f330b972e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Cell Nucleus
135 rdf:type schema:DefinedTerm
136 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
137 schema:name Medical and Health Sciences
138 rdf:type schema:DefinedTerm
139 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
140 schema:name Medical Microbiology
141 rdf:type schema:DefinedTerm
142 sg:journal.1019073 schema:issn 0001-6322
143 1432-0533
144 schema:name Acta Neuropathologica
145 rdf:type schema:Periodical
146 sg:person.01217137154.39 schema:affiliation https://www.grid.ac/institutes/grid.261331.4
147 schema:familyName Oglesbee
148 schema:givenName M.
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217137154.39
150 rdf:type schema:Person
151 sg:pub.10.1007/bf00684475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030413215
152 https://doi.org/10.1007/bf00684475
153 rdf:type schema:CreativeWork
154 sg:pub.10.1007/bf01311011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036330795
155 https://doi.org/10.1007/bf01311011
156 rdf:type schema:CreativeWork
157 sg:pub.10.1007/bf01315672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024579225
158 https://doi.org/10.1007/bf01315672
159 rdf:type schema:CreativeWork
160 sg:pub.10.1038/ki.1989.135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034335378
161 https://doi.org/10.1038/ki.1989.135
162 rdf:type schema:CreativeWork
163 https://app.dimensions.ai/details/publication/pub.1077652372 schema:CreativeWork
164 https://app.dimensions.ai/details/publication/pub.1077847950 schema:CreativeWork
165 https://app.dimensions.ai/details/publication/pub.1078050608 schema:CreativeWork
166 https://app.dimensions.ai/details/publication/pub.1078310187 schema:CreativeWork
167 https://app.dimensions.ai/details/publication/pub.1078653494 schema:CreativeWork
168 https://app.dimensions.ai/details/publication/pub.1079413911 schema:CreativeWork
169 https://app.dimensions.ai/details/publication/pub.1079815111 schema:CreativeWork
170 https://app.dimensions.ai/details/publication/pub.1080102575 schema:CreativeWork
171 https://app.dimensions.ai/details/publication/pub.1080129749 schema:CreativeWork
172 https://app.dimensions.ai/details/publication/pub.1080717433 schema:CreativeWork
173 https://app.dimensions.ai/details/publication/pub.1080756185 schema:CreativeWork
174 https://app.dimensions.ai/details/publication/pub.1081098414 schema:CreativeWork
175 https://app.dimensions.ai/details/publication/pub.1081354861 schema:CreativeWork
176 https://app.dimensions.ai/details/publication/pub.1081467380 schema:CreativeWork
177 https://app.dimensions.ai/details/publication/pub.1081857170 schema:CreativeWork
178 https://doi.org/10.1002/ar.1092050203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005907363
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/0006-8993(73)90527-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026519305
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/0021-9975(87)90022-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008760673
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/0042-6822(78)90357-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032572756
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/0042-6822(85)90132-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035536604
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/0165-3806(85)90185-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008427249
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/0166-0934(86)90016-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042218393
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/0166-0934(86)90022-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032821480
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/0166-0934(89)90040-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041576588
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/0248-4900(88)90007-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029916838
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/0306-4522(91)90124-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003210311
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/0922-3371(88)90051-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024426540
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/s0022-5320(67)80074-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041697360
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/s0022-5320(69)90085-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015687581
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/s0022-5320(71)80119-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037433104
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/s0022-5320(72)80022-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005835383
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/s0022-5320(80)90020-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003344744
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1038/ki.1989.135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034335378
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1083/jcb.104.5.1353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033238289
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1083/jcb.106.3.575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053667085
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1083/jcb.17.2.423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018473924
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1089/aid.1990.6.1131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059223084
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1099/0022-1317-67-10-2153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060355892
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1099/0022-1317-71-12-2847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060357403
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1111/j.1768-322x.1984.tb00220.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1061958541
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1126/science.3872478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062622032
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1159/000145131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005047153
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1210/jcem-34-2-257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064307680
233 rdf:type schema:CreativeWork
234 https://doi.org/10.3109/01913129009050870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039304893
235 rdf:type schema:CreativeWork
236 https://www.grid.ac/institutes/grid.261331.4 schema:alternateName The Ohio State University
237 schema:name The Department of Veterinary Pathobiology, The Ohio State University, 1925 Coffey Road, 43210, Columbus, OH, USA
238 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...