Microglial reactions to retrograde degeneration of tracer-identified thalamic neurons after frontal sensorimotor cortex lesions in adult rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-11

AUTHORS

J. C. Sørensen, I. Dalmau, J. Zimmer, B. Finsen

ABSTRACT

Thalamic neuronal degeneration after neocortical lesions involve both anterograde and retrograde components. This study deals with the thalamic microglial response after neocortical aspiration lesions, using fluorogold fluorescent prelabeling, to identify retrogradely degenerating thalamocortical neurons, combined with histochemical or immunohistochemical staining of microglial cells. Adult male Wistar rats were injected with the retrograde fluorescent tracer fluorogold, in the right sensorimotor cortex (forepaw area) in order to retrogradely label thalamic neurons projecting to this area. After 1 week, the fluorogold injection site was removed by aspiration, axotomizing at the same time the thalamic projection neurons now retrogradely labeled with fluorogold. After 3, 7, 14, and 28 days the animals were killed and processed for nucleoside diphosphatase histochemistry or complement type 3 receptor immuno-histochemistry and class I and II major histocompatibility complex immunohistochemistry using OX42, OX18, and OX6 antibodies. The histological analysis showed a prominent and progressive nucleoside diphosphatase-, OX42-, and OX6-positive microglial cell response in the ventrolateral, posterior, and ventrobasal thalamic nuclei with ongoing retrograde and anterograde neuronal degeneration. Initially the reactive microglia had a bushy morphology and were succeeded by ameboid microglia and microglial cluster cells as the reaction progressed. However, in the reticular thalamic nucleus, which suffered exclusively anterograde neuronal degeneration, a different picture was seen with only bushy microglia. The neurons undergoing retrograde degeneration in the ventrolateral, posterior, and ventrobasal thalamic nuclei were retrogradely labeled by the fluorogold tracer. Individual nucleoside diphosphatase-, OX42-, or OX6-positive microglial cells extended long cytoplasmic processes surrounding fluorogold-labeled neurons and had in some cases apparently phagocytized these. Several microglial cells were thus double-labeled with nucleoside diphosphatase or OX42 and fluorogold. In addition, small nucleoside diphosphatase-positive, fluorogold-labeled perivascular cells were observed in the neocortex near the fluorogold-injected and ablated neocortical areas and in the ipsilateral thalamus. This study demonstrates: (1) that the microglial response to thalamic degeneration after neocortical lesion is graded with a limited reaction to the well-known massive anterograde axonal degeneration and a more extended reaction to the axotomy-induced retrograde cell death; and (2) that also perivascular cells and possibly macrophages may contribute to this reaction, as seen by uptake of fluorogold from axotomized neurons in the degenerating thalamic nuclei. More... »

PAGES

203-212

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00227639

DOI

http://dx.doi.org/10.1007/bf00227639

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018783876

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8951389


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acid Anhydride Hydrolases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Astrocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorescent Dyes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glial Fibrillary Acidic Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histocytochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microglia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Motor Cortex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Degeneration", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Wistar", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Somatosensory Cortex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stilbamidines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thalamus", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Aarhus University", 
          "id": "https://www.grid.ac/institutes/grid.7048.b", 
          "name": [
            "Department of Neurobiology, Institute of Anatomy, University of Aarhus, DK-8000, Aarhus C, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "S\u00f8rensen", 
        "givenName": "J. C.", 
        "id": "sg:person.013363742452.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013363742452.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Autonomous University of Barcelona", 
          "id": "https://www.grid.ac/institutes/grid.7080.f", 
          "name": [
            "Unit of Histology, Department of Cell Biology and Physiology, Faculty of Medicine, Autonomous University of Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dalmau", 
        "givenName": "I.", 
        "id": "sg:person.01045111714.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045111714.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Southern Denmark", 
          "id": "https://www.grid.ac/institutes/grid.10825.3e", 
          "name": [
            "PharmaBiotec, Department of Anatomy and Cell Biology, Institute of Medical Biology, University of Odense, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zimmer", 
        "givenName": "J.", 
        "id": "sg:person.0575526357.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575526357.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Southern Denmark", 
          "id": "https://www.grid.ac/institutes/grid.10825.3e", 
          "name": [
            "PharmaBiotec, Department of Anatomy and Cell Biology, Institute of Medical Biology, University of Odense, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Finsen", 
        "givenName": "B.", 
        "id": "sg:person.01021713024.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021713024.78"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0165-3806(86)90108-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001908424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-3806(86)90108-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001908424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/exnr.1993.1041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002085741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00999498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002780848", 
          "https://doi.org/10.1007/bf00999498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00174083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002801099", 
          "https://doi.org/10.1007/bf00174083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00174083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002801099", 
          "https://doi.org/10.1007/bf00174083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.901480302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003555953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.901620302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004559211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-5728(89)90167-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009102381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-5728(89)90167-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009102381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.490210104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009263772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(86)90007-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009280942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(86)90007-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009280942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00228413", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009373815", 
          "https://doi.org/10.1007/bf00228413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00228413", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009373815", 
          "https://doi.org/10.1007/bf00228413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00228413", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009373815", 
          "https://doi.org/10.1007/bf00228413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(84)91338-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010943110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(91)90096-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011447527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(91)90096-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011447527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00325030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011508560", 
          "https://doi.org/10.1007/bf00325030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00325030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011508560", 
          "https://doi.org/10.1007/bf00325030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(89)90369-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015398481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(89)90369-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015398481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1460-9568.1991.tb00054.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015671239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1460-9568.1991.tb00054.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015671239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.901480303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017580344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.440070109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019561659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-4328(87)90161-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021087264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-4328(87)90161-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021087264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4886(83)90393-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023583698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.440070112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024871260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(86)90633-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027551465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(86)90633-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027551465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01611438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029468243", 
          "https://doi.org/10.1007/bf01611438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01611438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029468243", 
          "https://doi.org/10.1007/bf01611438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-2236(94)90098-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034006621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-2236(94)90098-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034006621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(90)90327-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037642697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(90)90327-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037642697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.903270110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037905890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(90)90083-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039726654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(90)90083-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039726654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.490200202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041351104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00296784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041917638", 
          "https://doi.org/10.1007/bf00296784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00296784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041917638", 
          "https://doi.org/10.1007/bf00296784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(91)90906-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041927348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(91)90906-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041927348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(77)90629-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043068541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(77)90629-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043068541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01104030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045508424", 
          "https://doi.org/10.1007/bf01104030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01104030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045508424", 
          "https://doi.org/10.1007/bf01104030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(88)90585-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045800511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(88)90585-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045800511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-5728(91)90008-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048086574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-5728(91)90008-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048086574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00186245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048605905", 
          "https://doi.org/10.1007/bf00186245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00186245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048605905", 
          "https://doi.org/10.1007/bf00186245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.903140113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049304768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01217752", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049531684", 
          "https://doi.org/10.1007/bf01217752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01217752", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049531684", 
          "https://doi.org/10.1007/bf01217752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076820230", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079947366", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080302394", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1996-11", 
    "datePublishedReg": "1996-11-01", 
    "description": "Thalamic neuronal degeneration after neocortical lesions involve both anterograde and retrograde components. This study deals with the thalamic microglial response after neocortical aspiration lesions, using fluorogold fluorescent prelabeling, to identify retrogradely degenerating thalamocortical neurons, combined with histochemical or immunohistochemical staining of microglial cells. Adult male Wistar rats were injected with the retrograde fluorescent tracer fluorogold, in the right sensorimotor cortex (forepaw area) in order to retrogradely label thalamic neurons projecting to this area. After 1 week, the fluorogold injection site was removed by aspiration, axotomizing at the same time the thalamic projection neurons now retrogradely labeled with fluorogold. After 3, 7, 14, and 28 days the animals were killed and processed for nucleoside diphosphatase histochemistry or complement type 3 receptor immuno-histochemistry and class I and II major histocompatibility complex immunohistochemistry using OX42, OX18, and OX6 antibodies. The histological analysis showed a prominent and progressive nucleoside diphosphatase-, OX42-, and OX6-positive microglial cell response in the ventrolateral, posterior, and ventrobasal thalamic nuclei with ongoing retrograde and anterograde neuronal degeneration. Initially the reactive microglia had a bushy morphology and were succeeded by ameboid microglia and microglial cluster cells as the reaction progressed. However, in the reticular thalamic nucleus, which suffered exclusively anterograde neuronal degeneration, a different picture was seen with only bushy microglia. The neurons undergoing retrograde degeneration in the ventrolateral, posterior, and ventrobasal thalamic nuclei were retrogradely labeled by the fluorogold tracer. Individual nucleoside diphosphatase-, OX42-, or OX6-positive microglial cells extended long cytoplasmic processes surrounding fluorogold-labeled neurons and had in some cases apparently phagocytized these. Several microglial cells were thus double-labeled with nucleoside diphosphatase or OX42 and fluorogold. In addition, small nucleoside diphosphatase-positive, fluorogold-labeled perivascular cells were observed in the neocortex near the fluorogold-injected and ablated neocortical areas and in the ipsilateral thalamus. This study demonstrates: (1) that the microglial response to thalamic degeneration after neocortical lesion is graded with a limited reaction to the well-known massive anterograde axonal degeneration and a more extended reaction to the axotomy-induced retrograde cell death; and (2) that also perivascular cells and possibly macrophages may contribute to this reaction, as seen by uptake of fluorogold from axotomized neurons in the degenerating thalamic nuclei.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00227639", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1005581", 
        "issn": [
          "0014-4819", 
          "1432-1106"
        ], 
        "name": "Experimental Brain Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "112"
      }
    ], 
    "name": "Microglial reactions to retrograde degeneration of tracer-identified thalamic neurons after frontal sensorimotor cortex lesions in adult rats", 
    "pagination": "203-212", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00227639"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "597fa9267d01be7d0dea1901c952b9eac1ab40f50fb4e43cbbaf5c3effa650ab"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1018783876"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0043312"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8951389"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00227639", 
      "https://app.dimensions.ai/details/publication/pub.1018783876"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T09:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000375_0000000375/records_91469_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2FBF00227639"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00227639'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00227639'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00227639'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00227639'


 

This table displays all metadata directly associated to this object as RDF triples.

291 TRIPLES      21 PREDICATES      86 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00227639 schema:about N06456e91c25040c4949bdf29c7d8326d
2 N1801ef443c4441e48f35ed5b393a799c
3 N2c0a59125f59470d9e2e4d15991d44dd
4 N41aa16c379694819893866b605f96eec
5 N461ceacf075f4de782495690bd9eda46
6 N4a84d4bdff0e4c2b9560436563758eac
7 N4b43089acac9471b92690438e6b571fd
8 N4c5a4989f093413c87682cebbbfba59b
9 N4d4fe0458463495283708f13876006d8
10 N672e0f17d31e4f7c9b3de0dcf5b2b1aa
11 N6ee3e32ab0f34d528ed8514dddcb5a43
12 N730e592d38b34359a70b826c60175764
13 N7a740c15a1fa4903a3344b463220fce6
14 N87af79bb3cdf4ef08fafad97698a6f21
15 Na5d498ddb38546c2a56e51e27f16b31e
16 Na5df09b88f744168bd322a70ed196b39
17 Na909cabfe29244e695b9e96be3ea7e10
18 Nbdefa388a0a143c8ab62cca6590d3d30
19 anzsrc-for:11
20 anzsrc-for:1109
21 schema:author N0ec5b5762a2b49abbfe7daceb88f1c0f
22 schema:citation sg:pub.10.1007/bf00174083
23 sg:pub.10.1007/bf00186245
24 sg:pub.10.1007/bf00228413
25 sg:pub.10.1007/bf00296784
26 sg:pub.10.1007/bf00325030
27 sg:pub.10.1007/bf00999498
28 sg:pub.10.1007/bf01104030
29 sg:pub.10.1007/bf01217752
30 sg:pub.10.1007/bf01611438
31 https://app.dimensions.ai/details/publication/pub.1076820230
32 https://app.dimensions.ai/details/publication/pub.1079947366
33 https://app.dimensions.ai/details/publication/pub.1080302394
34 https://doi.org/10.1002/cne.901480302
35 https://doi.org/10.1002/cne.901480303
36 https://doi.org/10.1002/cne.901620302
37 https://doi.org/10.1002/cne.903140113
38 https://doi.org/10.1002/cne.903270110
39 https://doi.org/10.1002/glia.440070109
40 https://doi.org/10.1002/glia.440070112
41 https://doi.org/10.1002/jnr.490200202
42 https://doi.org/10.1002/jnr.490210104
43 https://doi.org/10.1006/exnr.1993.1041
44 https://doi.org/10.1016/0006-8993(77)90629-1
45 https://doi.org/10.1016/0006-8993(84)91338-6
46 https://doi.org/10.1016/0006-8993(86)90633-5
47 https://doi.org/10.1016/0014-4886(83)90393-x
48 https://doi.org/10.1016/0165-3806(86)90108-2
49 https://doi.org/10.1016/0165-5728(89)90167-7
50 https://doi.org/10.1016/0165-5728(91)90008-u
51 https://doi.org/10.1016/0166-2236(94)90098-1
52 https://doi.org/10.1016/0166-4328(87)90161-6
53 https://doi.org/10.1016/0304-3940(88)90585-x
54 https://doi.org/10.1016/0304-3940(89)90369-8
55 https://doi.org/10.1016/0304-3940(91)90906-a
56 https://doi.org/10.1016/0306-4522(86)90007-2
57 https://doi.org/10.1016/0306-4522(90)90083-g
58 https://doi.org/10.1016/0306-4522(90)90327-z
59 https://doi.org/10.1016/0306-4522(91)90096-7
60 https://doi.org/10.1111/j.1460-9568.1991.tb00054.x
61 schema:datePublished 1996-11
62 schema:datePublishedReg 1996-11-01
63 schema:description Thalamic neuronal degeneration after neocortical lesions involve both anterograde and retrograde components. This study deals with the thalamic microglial response after neocortical aspiration lesions, using fluorogold fluorescent prelabeling, to identify retrogradely degenerating thalamocortical neurons, combined with histochemical or immunohistochemical staining of microglial cells. Adult male Wistar rats were injected with the retrograde fluorescent tracer fluorogold, in the right sensorimotor cortex (forepaw area) in order to retrogradely label thalamic neurons projecting to this area. After 1 week, the fluorogold injection site was removed by aspiration, axotomizing at the same time the thalamic projection neurons now retrogradely labeled with fluorogold. After 3, 7, 14, and 28 days the animals were killed and processed for nucleoside diphosphatase histochemistry or complement type 3 receptor immuno-histochemistry and class I and II major histocompatibility complex immunohistochemistry using OX42, OX18, and OX6 antibodies. The histological analysis showed a prominent and progressive nucleoside diphosphatase-, OX42-, and OX6-positive microglial cell response in the ventrolateral, posterior, and ventrobasal thalamic nuclei with ongoing retrograde and anterograde neuronal degeneration. Initially the reactive microglia had a bushy morphology and were succeeded by ameboid microglia and microglial cluster cells as the reaction progressed. However, in the reticular thalamic nucleus, which suffered exclusively anterograde neuronal degeneration, a different picture was seen with only bushy microglia. The neurons undergoing retrograde degeneration in the ventrolateral, posterior, and ventrobasal thalamic nuclei were retrogradely labeled by the fluorogold tracer. Individual nucleoside diphosphatase-, OX42-, or OX6-positive microglial cells extended long cytoplasmic processes surrounding fluorogold-labeled neurons and had in some cases apparently phagocytized these. Several microglial cells were thus double-labeled with nucleoside diphosphatase or OX42 and fluorogold. In addition, small nucleoside diphosphatase-positive, fluorogold-labeled perivascular cells were observed in the neocortex near the fluorogold-injected and ablated neocortical areas and in the ipsilateral thalamus. This study demonstrates: (1) that the microglial response to thalamic degeneration after neocortical lesion is graded with a limited reaction to the well-known massive anterograde axonal degeneration and a more extended reaction to the axotomy-induced retrograde cell death; and (2) that also perivascular cells and possibly macrophages may contribute to this reaction, as seen by uptake of fluorogold from axotomized neurons in the degenerating thalamic nuclei.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree false
67 schema:isPartOf N0a6ad879270146558362ca35af52cfe0
68 N2a74e3c162094f63a003f718759f5a80
69 sg:journal.1005581
70 schema:name Microglial reactions to retrograde degeneration of tracer-identified thalamic neurons after frontal sensorimotor cortex lesions in adult rats
71 schema:pagination 203-212
72 schema:productId Nac4c2b98d97f4da0a20847bf2cdebc5d
73 Nbb475cd1bc144fd5a3812fa3727d5fe7
74 Nc0564f9424d54dfd9a666f10b6cff3c0
75 Nd8f1dff416e143928eb4e2b525fa3b8a
76 Nf36c7761cc894017bbfd58be75f63ba1
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018783876
78 https://doi.org/10.1007/bf00227639
79 schema:sdDatePublished 2019-04-15T09:04
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher N44d423c820da41dfab0f4d93436fe3fc
82 schema:url http://link.springer.com/10.1007%2FBF00227639
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N06456e91c25040c4949bdf29c7d8326d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Nerve Degeneration
88 rdf:type schema:DefinedTerm
89 N0a6ad879270146558362ca35af52cfe0 schema:issueNumber 2
90 rdf:type schema:PublicationIssue
91 N0ec5b5762a2b49abbfe7daceb88f1c0f rdf:first sg:person.013363742452.53
92 rdf:rest N96e0f72c95b94413811590eeae72ff87
93 N1801ef443c4441e48f35ed5b393a799c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Animals
95 rdf:type schema:DefinedTerm
96 N2a74e3c162094f63a003f718759f5a80 schema:volumeNumber 112
97 rdf:type schema:PublicationVolume
98 N2c0a59125f59470d9e2e4d15991d44dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Antibodies, Monoclonal
100 rdf:type schema:DefinedTerm
101 N41aa16c379694819893866b605f96eec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Stilbamidines
103 rdf:type schema:DefinedTerm
104 N44d423c820da41dfab0f4d93436fe3fc schema:name Springer Nature - SN SciGraph project
105 rdf:type schema:Organization
106 N461ceacf075f4de782495690bd9eda46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Rats, Wistar
108 rdf:type schema:DefinedTerm
109 N4a84d4bdff0e4c2b9560436563758eac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Fluorescent Dyes
111 rdf:type schema:DefinedTerm
112 N4b43089acac9471b92690438e6b571fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Astrocytes
114 rdf:type schema:DefinedTerm
115 N4c5a4989f093413c87682cebbbfba59b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Glial Fibrillary Acidic Protein
117 rdf:type schema:DefinedTerm
118 N4d4fe0458463495283708f13876006d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Rats
120 rdf:type schema:DefinedTerm
121 N5d061800a2b44c7bb2a2909145a55fad rdf:first sg:person.0575526357.42
122 rdf:rest N7a3b4ba4dce943999fbd428051278cb4
123 N672e0f17d31e4f7c9b3de0dcf5b2b1aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Histocytochemistry
125 rdf:type schema:DefinedTerm
126 N6ee3e32ab0f34d528ed8514dddcb5a43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Microglia
128 rdf:type schema:DefinedTerm
129 N730e592d38b34359a70b826c60175764 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Immunohistochemistry
131 rdf:type schema:DefinedTerm
132 N7a3b4ba4dce943999fbd428051278cb4 rdf:first sg:person.01021713024.78
133 rdf:rest rdf:nil
134 N7a740c15a1fa4903a3344b463220fce6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Acid Anhydride Hydrolases
136 rdf:type schema:DefinedTerm
137 N87af79bb3cdf4ef08fafad97698a6f21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Somatosensory Cortex
139 rdf:type schema:DefinedTerm
140 N96e0f72c95b94413811590eeae72ff87 rdf:first sg:person.01045111714.64
141 rdf:rest N5d061800a2b44c7bb2a2909145a55fad
142 Na5d498ddb38546c2a56e51e27f16b31e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Male
144 rdf:type schema:DefinedTerm
145 Na5df09b88f744168bd322a70ed196b39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Motor Cortex
147 rdf:type schema:DefinedTerm
148 Na909cabfe29244e695b9e96be3ea7e10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Thalamus
150 rdf:type schema:DefinedTerm
151 Nac4c2b98d97f4da0a20847bf2cdebc5d schema:name readcube_id
152 schema:value 597fa9267d01be7d0dea1901c952b9eac1ab40f50fb4e43cbbaf5c3effa650ab
153 rdf:type schema:PropertyValue
154 Nbb475cd1bc144fd5a3812fa3727d5fe7 schema:name dimensions_id
155 schema:value pub.1018783876
156 rdf:type schema:PropertyValue
157 Nbdefa388a0a143c8ab62cca6590d3d30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Neurons
159 rdf:type schema:DefinedTerm
160 Nc0564f9424d54dfd9a666f10b6cff3c0 schema:name doi
161 schema:value 10.1007/bf00227639
162 rdf:type schema:PropertyValue
163 Nd8f1dff416e143928eb4e2b525fa3b8a schema:name nlm_unique_id
164 schema:value 0043312
165 rdf:type schema:PropertyValue
166 Nf36c7761cc894017bbfd58be75f63ba1 schema:name pubmed_id
167 schema:value 8951389
168 rdf:type schema:PropertyValue
169 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
170 schema:name Medical and Health Sciences
171 rdf:type schema:DefinedTerm
172 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
173 schema:name Neurosciences
174 rdf:type schema:DefinedTerm
175 sg:journal.1005581 schema:issn 0014-4819
176 1432-1106
177 schema:name Experimental Brain Research
178 rdf:type schema:Periodical
179 sg:person.01021713024.78 schema:affiliation https://www.grid.ac/institutes/grid.10825.3e
180 schema:familyName Finsen
181 schema:givenName B.
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021713024.78
183 rdf:type schema:Person
184 sg:person.01045111714.64 schema:affiliation https://www.grid.ac/institutes/grid.7080.f
185 schema:familyName Dalmau
186 schema:givenName I.
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045111714.64
188 rdf:type schema:Person
189 sg:person.013363742452.53 schema:affiliation https://www.grid.ac/institutes/grid.7048.b
190 schema:familyName Sørensen
191 schema:givenName J. C.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013363742452.53
193 rdf:type schema:Person
194 sg:person.0575526357.42 schema:affiliation https://www.grid.ac/institutes/grid.10825.3e
195 schema:familyName Zimmer
196 schema:givenName J.
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575526357.42
198 rdf:type schema:Person
199 sg:pub.10.1007/bf00174083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002801099
200 https://doi.org/10.1007/bf00174083
201 rdf:type schema:CreativeWork
202 sg:pub.10.1007/bf00186245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048605905
203 https://doi.org/10.1007/bf00186245
204 rdf:type schema:CreativeWork
205 sg:pub.10.1007/bf00228413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009373815
206 https://doi.org/10.1007/bf00228413
207 rdf:type schema:CreativeWork
208 sg:pub.10.1007/bf00296784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041917638
209 https://doi.org/10.1007/bf00296784
210 rdf:type schema:CreativeWork
211 sg:pub.10.1007/bf00325030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011508560
212 https://doi.org/10.1007/bf00325030
213 rdf:type schema:CreativeWork
214 sg:pub.10.1007/bf00999498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002780848
215 https://doi.org/10.1007/bf00999498
216 rdf:type schema:CreativeWork
217 sg:pub.10.1007/bf01104030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045508424
218 https://doi.org/10.1007/bf01104030
219 rdf:type schema:CreativeWork
220 sg:pub.10.1007/bf01217752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049531684
221 https://doi.org/10.1007/bf01217752
222 rdf:type schema:CreativeWork
223 sg:pub.10.1007/bf01611438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029468243
224 https://doi.org/10.1007/bf01611438
225 rdf:type schema:CreativeWork
226 https://app.dimensions.ai/details/publication/pub.1076820230 schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1079947366 schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1080302394 schema:CreativeWork
229 https://doi.org/10.1002/cne.901480302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003555953
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1002/cne.901480303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017580344
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1002/cne.901620302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004559211
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1002/cne.903140113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049304768
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1002/cne.903270110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037905890
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1002/glia.440070109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019561659
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1002/glia.440070112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024871260
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1002/jnr.490200202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041351104
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1002/jnr.490210104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009263772
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1006/exnr.1993.1041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002085741
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/0006-8993(77)90629-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043068541
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/0006-8993(84)91338-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010943110
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/0006-8993(86)90633-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027551465
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/0014-4886(83)90393-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023583698
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/0165-3806(86)90108-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001908424
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/0165-5728(89)90167-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009102381
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/0165-5728(91)90008-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1048086574
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/0166-2236(94)90098-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034006621
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/0166-4328(87)90161-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021087264
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/0304-3940(88)90585-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045800511
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/0304-3940(89)90369-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015398481
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/0304-3940(91)90906-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1041927348
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/0306-4522(86)90007-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009280942
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/0306-4522(90)90083-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1039726654
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/0306-4522(90)90327-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1037642697
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/0306-4522(91)90096-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011447527
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1111/j.1460-9568.1991.tb00054.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015671239
282 rdf:type schema:CreativeWork
283 https://www.grid.ac/institutes/grid.10825.3e schema:alternateName University of Southern Denmark
284 schema:name PharmaBiotec, Department of Anatomy and Cell Biology, Institute of Medical Biology, University of Odense, Denmark
285 rdf:type schema:Organization
286 https://www.grid.ac/institutes/grid.7048.b schema:alternateName Aarhus University
287 schema:name Department of Neurobiology, Institute of Anatomy, University of Aarhus, DK-8000, Aarhus C, Denmark
288 rdf:type schema:Organization
289 https://www.grid.ac/institutes/grid.7080.f schema:alternateName Autonomous University of Barcelona
290 schema:name Unit of Histology, Department of Cell Biology and Physiology, Faculty of Medicine, Autonomous University of Barcelona, Spain
291 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...