Respiratory network remains functional in a mature guinea pig brainstem isolated in vitro View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-08

AUTHORS

M. P. Morin-Surun, E. Boudinot, H. Sarraseca, G. Fortin, M. Denavit-Saubié

ABSTRACT

We previously developed a perfused isolated brainstem preparation in the adult guinea pig (Morin-Surun and Denavit-Saubie 1989a) which permitted us to describe several types of rhythmic neuronal discharge. In the present study, we demonstrate that nearly all the periodic neuronal activity we recorded in the ventral respiratory areas were directly related to the respiratory-like periodic output of the hypoglossal nerve. This respiratory-like activity lasted several hours only when the brainstem was perfused by the basilar artery. This shows the necessity of the intraarterial perfusion to preserve a functional respiratory network. Analysis of the characteristics of hypoglossal respiratory-like activity shows that (1) two types of respiratory rhythms can be recorded; one with long respiratory phases (inspiratory and expiratory) and one with short respiratory phases. Depending on the preparation, either type occurs alone or intermingled with the other. (2) The shape of the inspiratory-like activity can change throughout the recording period while the periodicity remains stable. This preparation generates a respiratory rhythm and enables us to dissociate the different mechanisms involved in respiratory neurogenesis. More... »

PAGES

375-383

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00227251

DOI

http://dx.doi.org/10.1007/bf00227251

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044147157

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1397151


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Stem", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electrophysiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Extracellular Space", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Guinea Pigs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histocytochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypoglossal Nerve", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Net", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiration", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Biologie Fonctionnelle du Neurone, Institut Alfred Fessard, CNRS, F-91198, Gif-sur-Yvette Cedex, France", 
          "id": "http://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "Biologie Fonctionnelle du Neurone, Institut Alfred Fessard, CNRS, F-91198, Gif-sur-Yvette Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morin-Surun", 
        "givenName": "M. P.", 
        "id": "sg:person.01162132021.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162132021.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biologie Fonctionnelle du Neurone, Institut Alfred Fessard, CNRS, F-91198, Gif-sur-Yvette Cedex, France", 
          "id": "http://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "Biologie Fonctionnelle du Neurone, Institut Alfred Fessard, CNRS, F-91198, Gif-sur-Yvette Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boudinot", 
        "givenName": "E.", 
        "id": "sg:person.01221460776.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221460776.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biologie Fonctionnelle du Neurone, Institut Alfred Fessard, CNRS, F-91198, Gif-sur-Yvette Cedex, France", 
          "id": "http://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "Biologie Fonctionnelle du Neurone, Institut Alfred Fessard, CNRS, F-91198, Gif-sur-Yvette Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sarraseca", 
        "givenName": "H.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biologie Fonctionnelle du Neurone, Institut Alfred Fessard, CNRS, F-91198, Gif-sur-Yvette Cedex, France", 
          "id": "http://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "Biologie Fonctionnelle du Neurone, Institut Alfred Fessard, CNRS, F-91198, Gif-sur-Yvette Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fortin", 
        "givenName": "G.", 
        "id": "sg:person.01015630533.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015630533.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biologie Fonctionnelle du Neurone, Institut Alfred Fessard, CNRS, F-91198, Gif-sur-Yvette Cedex, France", 
          "id": "http://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "Biologie Fonctionnelle du Neurone, Institut Alfred Fessard, CNRS, F-91198, Gif-sur-Yvette Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Denavit-Saubi\u00e9", 
        "givenName": "M.", 
        "id": "sg:person.054274422.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.054274422.79"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf01845844", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007432178", 
          "https://doi.org/10.1007/bf01845844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00337025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004045558", 
          "https://doi.org/10.1007/bf00337025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-68657-3_22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017931973", 
          "https://doi.org/10.1007/978-3-642-68657-3_22"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1992-08", 
    "datePublishedReg": "1992-08-01", 
    "description": "We previously developed a perfused isolated brainstem preparation in the adult guinea pig (Morin-Surun and Denavit-Saubie 1989a) which permitted us to describe several types of rhythmic neuronal discharge. In the present study, we demonstrate that nearly all the periodic neuronal activity we recorded in the ventral respiratory areas were directly related to the respiratory-like periodic output of the hypoglossal nerve. This respiratory-like activity lasted several hours only when the brainstem was perfused by the basilar artery. This shows the necessity of the intraarterial perfusion to preserve a functional respiratory network. Analysis of the characteristics of hypoglossal respiratory-like activity shows that (1) two types of respiratory rhythms can be recorded; one with long respiratory phases (inspiratory and expiratory) and one with short respiratory phases. Depending on the preparation, either type occurs alone or intermingled with the other. (2) The shape of the inspiratory-like activity can change throughout the recording period while the periodicity remains stable. This preparation generates a respiratory rhythm and enables us to dissociate the different mechanisms involved in respiratory neurogenesis.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf00227251", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1005581", 
        "issn": [
          "0014-4819", 
          "1432-1106"
        ], 
        "name": "Experimental Brain Research", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "90"
      }
    ], 
    "keywords": [
      "respiratory-like activity", 
      "respiratory rhythm", 
      "respiratory network", 
      "rhythmic neuronal discharge", 
      "ventral respiratory area", 
      "guinea pig brainstem", 
      "respiratory phases", 
      "isolated brainstem preparation", 
      "adult guinea pigs", 
      "periodic neuronal activity", 
      "intraarterial perfusion", 
      "hypoglossal nerve", 
      "basilar artery", 
      "brainstem preparation", 
      "neuronal discharge", 
      "neuronal activity", 
      "guinea pigs", 
      "respiratory area", 
      "brainstem", 
      "recording period", 
      "present study", 
      "rhythm", 
      "different mechanisms", 
      "nerve", 
      "artery", 
      "perfusion", 
      "activity", 
      "neurogenesis", 
      "pigs", 
      "hours", 
      "types", 
      "period", 
      "discharge", 
      "preparation", 
      "study", 
      "mechanism", 
      "analysis", 
      "area", 
      "characteristics", 
      "phase", 
      "necessity", 
      "output", 
      "network", 
      "periodicity", 
      "shape", 
      "periodic output"
    ], 
    "name": "Respiratory network remains functional in a mature guinea pig brainstem isolated in vitro", 
    "pagination": "375-383", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1044147157"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00227251"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "1397151"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00227251", 
      "https://app.dimensions.ai/details/publication/pub.1044147157"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T16:51", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_248.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf00227251"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00227251'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00227251'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00227251'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00227251'


 

This table displays all metadata directly associated to this object as RDF triples.

182 TRIPLES      21 PREDICATES      84 URIs      73 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00227251 schema:about N0a571ec2e74141e8b056c9fd06e1dafd
2 N0d680806ac71419c9f814a4b55efced2
3 N115429e2221843568d5d47538a0bb79c
4 N5dfc53ef8f434613b76fb54b31ab809a
5 N776d9a3ee78649d1bd1526d2dbe7b80b
6 N878305e4c0614ad492a8b6a020ec4e2c
7 N886e5e4bbeaa49e3a31f1b4902c5638e
8 Nbe078ddedb2642beb878812533944489
9 Nc45785ad705f4f1ea878645dc1c613c6
10 anzsrc-for:11
11 anzsrc-for:1109
12 schema:author N505c545bd9704219ba7c029887e6c061
13 schema:citation sg:pub.10.1007/978-3-642-68657-3_22
14 sg:pub.10.1007/bf00337025
15 sg:pub.10.1007/bf01845844
16 schema:datePublished 1992-08
17 schema:datePublishedReg 1992-08-01
18 schema:description We previously developed a perfused isolated brainstem preparation in the adult guinea pig (Morin-Surun and Denavit-Saubie 1989a) which permitted us to describe several types of rhythmic neuronal discharge. In the present study, we demonstrate that nearly all the periodic neuronal activity we recorded in the ventral respiratory areas were directly related to the respiratory-like periodic output of the hypoglossal nerve. This respiratory-like activity lasted several hours only when the brainstem was perfused by the basilar artery. This shows the necessity of the intraarterial perfusion to preserve a functional respiratory network. Analysis of the characteristics of hypoglossal respiratory-like activity shows that (1) two types of respiratory rhythms can be recorded; one with long respiratory phases (inspiratory and expiratory) and one with short respiratory phases. Depending on the preparation, either type occurs alone or intermingled with the other. (2) The shape of the inspiratory-like activity can change throughout the recording period while the periodicity remains stable. This preparation generates a respiratory rhythm and enables us to dissociate the different mechanisms involved in respiratory neurogenesis.
19 schema:genre article
20 schema:isAccessibleForFree false
21 schema:isPartOf N4cad7cf86fa34832a1b316100a80a97e
22 Na17e8ebbffa3433591c9fc4dc51f141e
23 sg:journal.1005581
24 schema:keywords activity
25 adult guinea pigs
26 analysis
27 area
28 artery
29 basilar artery
30 brainstem
31 brainstem preparation
32 characteristics
33 different mechanisms
34 discharge
35 guinea pig brainstem
36 guinea pigs
37 hours
38 hypoglossal nerve
39 intraarterial perfusion
40 isolated brainstem preparation
41 mechanism
42 necessity
43 nerve
44 network
45 neurogenesis
46 neuronal activity
47 neuronal discharge
48 output
49 perfusion
50 period
51 periodic neuronal activity
52 periodic output
53 periodicity
54 phase
55 pigs
56 preparation
57 present study
58 recording period
59 respiratory area
60 respiratory network
61 respiratory phases
62 respiratory rhythm
63 respiratory-like activity
64 rhythm
65 rhythmic neuronal discharge
66 shape
67 study
68 types
69 ventral respiratory area
70 schema:name Respiratory network remains functional in a mature guinea pig brainstem isolated in vitro
71 schema:pagination 375-383
72 schema:productId N72aa3ad164104b20ba9628372b9aabc9
73 N9abf4d3382924c07b0174ecb02f6bd2f
74 Nad5c1cea1e2440cdbe953fca95c2c345
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044147157
76 https://doi.org/10.1007/bf00227251
77 schema:sdDatePublished 2022-08-04T16:51
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N38785237c52d4a2ba345a9f67b230ace
80 schema:url https://doi.org/10.1007/bf00227251
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N0a571ec2e74141e8b056c9fd06e1dafd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Nerve Net
86 rdf:type schema:DefinedTerm
87 N0d680806ac71419c9f814a4b55efced2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Histocytochemistry
89 rdf:type schema:DefinedTerm
90 N115429e2221843568d5d47538a0bb79c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Guinea Pigs
92 rdf:type schema:DefinedTerm
93 N38785237c52d4a2ba345a9f67b230ace schema:name Springer Nature - SN SciGraph project
94 rdf:type schema:Organization
95 N4cad7cf86fa34832a1b316100a80a97e schema:issueNumber 2
96 rdf:type schema:PublicationIssue
97 N505c545bd9704219ba7c029887e6c061 rdf:first sg:person.01162132021.24
98 rdf:rest N810550c7854b45d5a17fe911a3656839
99 N5dfc53ef8f434613b76fb54b31ab809a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Hypoglossal Nerve
101 rdf:type schema:DefinedTerm
102 N72aa3ad164104b20ba9628372b9aabc9 schema:name dimensions_id
103 schema:value pub.1044147157
104 rdf:type schema:PropertyValue
105 N776d9a3ee78649d1bd1526d2dbe7b80b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Electrophysiology
107 rdf:type schema:DefinedTerm
108 N810550c7854b45d5a17fe911a3656839 rdf:first sg:person.01221460776.18
109 rdf:rest Nc2bb131b627345c1b0c926cbbcaa6ab5
110 N878305e4c0614ad492a8b6a020ec4e2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Brain Stem
112 rdf:type schema:DefinedTerm
113 N886e5e4bbeaa49e3a31f1b4902c5638e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Respiration
115 rdf:type schema:DefinedTerm
116 N9abf4d3382924c07b0174ecb02f6bd2f schema:name pubmed_id
117 schema:value 1397151
118 rdf:type schema:PropertyValue
119 Na17e8ebbffa3433591c9fc4dc51f141e schema:volumeNumber 90
120 rdf:type schema:PublicationVolume
121 Nad5c1cea1e2440cdbe953fca95c2c345 schema:name doi
122 schema:value 10.1007/bf00227251
123 rdf:type schema:PropertyValue
124 Nb57f85db03734f68ae8519a91beeec73 schema:affiliation grid-institutes:grid.4444.0
125 schema:familyName Sarraseca
126 schema:givenName H.
127 rdf:type schema:Person
128 Nbe078ddedb2642beb878812533944489 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Extracellular Space
130 rdf:type schema:DefinedTerm
131 Nc2bb131b627345c1b0c926cbbcaa6ab5 rdf:first Nb57f85db03734f68ae8519a91beeec73
132 rdf:rest Nf70174b7dbf247adb62e7daaa6a95e1e
133 Nc45785ad705f4f1ea878645dc1c613c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Animals
135 rdf:type schema:DefinedTerm
136 Nd701a2bc0e1b48aaa54d1850d97abee4 rdf:first sg:person.054274422.79
137 rdf:rest rdf:nil
138 Nf70174b7dbf247adb62e7daaa6a95e1e rdf:first sg:person.01015630533.39
139 rdf:rest Nd701a2bc0e1b48aaa54d1850d97abee4
140 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
141 schema:name Medical and Health Sciences
142 rdf:type schema:DefinedTerm
143 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
144 schema:name Neurosciences
145 rdf:type schema:DefinedTerm
146 sg:journal.1005581 schema:issn 0014-4819
147 1432-1106
148 schema:name Experimental Brain Research
149 schema:publisher Springer Nature
150 rdf:type schema:Periodical
151 sg:person.01015630533.39 schema:affiliation grid-institutes:grid.4444.0
152 schema:familyName Fortin
153 schema:givenName G.
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015630533.39
155 rdf:type schema:Person
156 sg:person.01162132021.24 schema:affiliation grid-institutes:grid.4444.0
157 schema:familyName Morin-Surun
158 schema:givenName M. P.
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162132021.24
160 rdf:type schema:Person
161 sg:person.01221460776.18 schema:affiliation grid-institutes:grid.4444.0
162 schema:familyName Boudinot
163 schema:givenName E.
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221460776.18
165 rdf:type schema:Person
166 sg:person.054274422.79 schema:affiliation grid-institutes:grid.4444.0
167 schema:familyName Denavit-Saubié
168 schema:givenName M.
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.054274422.79
170 rdf:type schema:Person
171 sg:pub.10.1007/978-3-642-68657-3_22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017931973
172 https://doi.org/10.1007/978-3-642-68657-3_22
173 rdf:type schema:CreativeWork
174 sg:pub.10.1007/bf00337025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004045558
175 https://doi.org/10.1007/bf00337025
176 rdf:type schema:CreativeWork
177 sg:pub.10.1007/bf01845844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007432178
178 https://doi.org/10.1007/bf01845844
179 rdf:type schema:CreativeWork
180 grid-institutes:grid.4444.0 schema:alternateName Biologie Fonctionnelle du Neurone, Institut Alfred Fessard, CNRS, F-91198, Gif-sur-Yvette Cedex, France
181 schema:name Biologie Fonctionnelle du Neurone, Institut Alfred Fessard, CNRS, F-91198, Gif-sur-Yvette Cedex, France
182 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...