Phenotypic heterogeneity of vascular endothelial cells in the human kidney View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1989-04

AUTHORS

Tsutomu Kinjo, Manehisa Takashi, Koji Miyake, Hiroshi Nagura

ABSTRACT

To clarify the structural base of immune response occurring in the kidney, we investigated the antigenic and functional properties of vascular endothelial cells. Peritubular capillary endothelial cells exhibited the same immuno-histochemical characteristics (OKM5-positive, HLA-DR-positive, Factor VIII/von Willebrand factor antigen-negative, Interleukin 1-positive) as a peripheral blood macrophage subset capable of presenting soluble antigens and triggering the autologous mixed lymphocyte reaction. On the other hand, endothelial cells of glomerular capillary loops, considered to be involved in blood coagulation, were OKM5-negative, HLA-DR-positive, Factor VIII/von Willebrand factor antigen-positive, Interleukin 1-positive. Thus the results of this study suggest that vascular endothelial cells in different anatomic compartments of the kidney express surface antigens heterogenously and may play different roles in the immune reaction. More... »

PAGES

27-34

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00224715

DOI

http://dx.doi.org/10.1007/bf00224715

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024400791

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2713894


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