Molecular definition of an elusive third HLA-A9 molecule: HLA-A9.3 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-01

AUTHORS

Ann-Margaret Little, J. Alejandro Madrigal, Peter Parham

ABSTRACT

The HLA-A9 family has been characterized as possessing two well defined specificities; HLA-A23 and A24. Serological studies have suggested the presence of a third member of this family HLA-A9.3, however there is doubt surrounding the existence of this specificity. HLA-A23, A24, and the putative A9.3 proteins were analyzed biochemically by immunoprecipitation and isoelectric focusing. Both HLA-A24 and A9.3 have identical isoelectric points whereas A23 is different. We have sequenced cDNA encoding HLA-A23, A24, and A9.3. From the observed protein sequences, we found A9.3 to differ from A24 by two amino acid substitutions located in the alpha 2 helix of the class I molecule. These substitutions are expected to significantly change the shape of the peptide binding cleft. More... »

PAGES

41-45

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00216625

DOI

http://dx.doi.org/10.1007/bf00216625

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031634654

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1729171


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