Provocative tests with psychostimulant drugs in schizophrenia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-04

AUTHORS

J. A. Lieberman, J. M. Kane, J. Alvir

ABSTRACT

The psychotogenic effects of psychostimulant drugs have provided a major line of evidence in support of the DA hypothesis of schizophrenia. To evaluate the effects of psychostimulant (PS) drug in schizophrenia and the clinical variables which may influence their expression, we reviewed 36 studies of PS drugs in patients with schizophrenia. Approximately 40% evidence a psychotogenic response to PS administration in doses that are subpsychotogenic in normals. Specific clinical variables appear to modify this response, including diagnosis, degree and type of psychopathology, stage of illness and pharmacologic status at the time of testing. Non-amphetamine-like PS drugs, e.g., methylphenidate, appear to have greater psychotogenic potency than amphetamine-like PS drugs. These results suggest the presence of a subgroup of schizophrenic patients who exhibit psychotic symptom activation with PS in a state dependent or independent fashion. This biologic phenomenon may be clinically exploitable and should be investigated further. More... »

PAGES

415-433

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00216006

DOI

http://dx.doi.org/10.1007/bf00216006

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047611583

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2884687


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