Effects of pyrazolopyridines and a triazolopyridazine on the pentobarbital discriminative stimulus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-12

AUTHORS

R. Young, R. A. Glennon, W. L. Dewey

ABSTRACT

Rats were trained to discriminate injections of racemic pentobarbital (5.0 mg/kg) from saline in a two-lever drug discrimination task. After stable discrimination performance was attained, stimulus generalization studies were conducted with another barbiturate (barbital), benzodiazepine derivatives (diazepam and chlordiazepoxide), pyrazolopyridine derivatives (etazolate, cartazolate, and tracazolate), and a triazolopyridazine (CL 218, 872). The pentobarbital stimulus generalized to all of these compounds, except cartazolate. In addition, the administration of the benzodiazepine receptor antagonist flumazepil prior to benzodiazepine or triazolopyridazine administration produced a dose-related antagonism of each generalization. In contrast, the administration of flumazepil before barbiturate or pyrazolopyridine (i.e., etazolate or tracazolate) injection resulted in no attenuation of these generalizations. The results indicate that while certain barbiturates, benzodiazepines, pyrazolopyridines, and triazolopyridazines are capable of producing similar stimulus effects, the behavioral actions of these agents can be differentiated on the basis of their susceptibility to antagonism by flumazepil. More... »

PAGES

494-497

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00207241

DOI

http://dx.doi.org/10.1007/bf00207241

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006068098

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2893416


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