Anonymous markers located on chromosome 6 in the HLA-A class I region: allelic distribution in genetic haemochromatosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-04

AUTHORS

Joëlle Boretto, Anne-Marie Jouanolle, Jacqueline Yaouanq, Abdel El Kahloun, Valérie Mauvieux, Martine Blayau, Muriel Perichon, André Le Treut, John Clayton, Nicolas Borot, Jean-Yves Le Gall, Pierre Pontarotti, Véronique David

ABSTRACT

Two yeast artificial chromosomes of the HLA class I region were subcloned. Four of the subclones studied displayed restriction polymorphisms that corresponded to six bi-allelic series. Allelic distribution of the anonymous markers was then studied by comparing a control population with a group of patients with familial haemochromatosis. Only one marker presents an unequivocal association with the haemochromatosis gene and is 100kb centromeric to HLA-A. This association however is not as strong as with HLA-A3. The results suggest two possible locations for the haemochromatosis gene: less than 100kb centromeric to the HLA-A locus, or on the telomeric side. More... »

PAGES

33-36

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00207038

DOI

http://dx.doi.org/10.1007/bf00207038

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045217620

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1349563


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