HLA class I gene polymorphism in genetic hemochromatosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-08

AUTHORS

Anne-Marie Jouanolle, Jacqueline Yaouanq, Martine Blayau, Muriel Périchon, Renée Fauchet, Marie-Pierre Font, Jean-Yves Le Gall, Véronique David

ABSTRACT

The authors have studied HLA class I polymorphism in an attempt to identify a genomic marker of the hemochromatosis gene. Five enzymes were used (HindIII, EcoRI, EcoRV, PvuII, and HincII) in 47–106 unrelated patients and 71–91 controls. Both populations were HLA-typed. The relationship between the restriction fragments and HLA-A antigens was considered. Comparison of the two groups revealed a significantly high frequence of one 14kb EcoRI fragment among the HLA-A3 hemochromatosis patients. The fragment hybridizes to an HLA-A specific probe but not to an HLA-B specific probe, and is associated with the hemochromatosis gene, which is itself associated with HLA-A3. More... »

PAGES

279-282

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00206746

DOI

http://dx.doi.org/10.1007/bf00206746

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000472504

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1975556


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180 Laboratoire de Biochimie Médicale B, CHU Pontchaillou F, F-35033, Rennes Cédex, France
181 rdf:type schema:Organization
182 grid-institutes:grid.413328.f schema:alternateName Unité INSERM U 93, Hôpital St. Louis, F-75010, Paris, France
183 schema:name Unité INSERM U 93, Hôpital St. Louis, F-75010, Paris, France
184 rdf:type schema:Organization
185 grid-institutes:grid.418199.c schema:alternateName Centre Régional de Transfusion sanguine, CHU Pontchaillou F, F-35033, Rennes Cédex, France
186 schema:name Centre Régional de Transfusion sanguine, CHU Pontchaillou F, F-35033, Rennes Cédex, France
187 rdf:type schema:Organization
 




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