Segmental exchange between MHC class I genes in a higher primate: recombination in the gorilla between the ancestor of a ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-09

AUTHORS

David I. Watkins, Zheng W. Chen, Theodore L. Garber, Austin L. Hughes, Norman L. Letvin

ABSTRACT

Classical human major histocompatibility complex (MHC) class I molecules are the products of highly diverse gene loci. It has been suggested that segmental exchange may play a role in the generation of diversity at the antigen recognition site of MHC class I molecules. Here we present the cloning, sequencing and expression of two gorilla A locus cDNAs. One of these cDNAs shows remarkable similarity to the non-functional HLA-AR locus gene (5.4-LBF) only in exon 2. The remainder of the cDNA, however, is most closely related to other classical higher primate A locus genes. This suggests that a segmental exchange may have occurred between the ancestor of the non-functional HLA-AR gene and a classical gorilla A locus gene. Furthermore, the recombination event resulting in Gogo-A3 has affected its antigen recognition site. These data, therefore, demonstrate that segmental exchange can generate diversity at the antigen recognition sites of primate MHC class I molecules and suggest that non-functional genes can contribute to the generation of diversity of classical MHC class I genes. More... »

PAGES

185-191

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00205822

DOI

http://dx.doi.org/10.1007/bf00205822

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048107163

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1894312


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