Stage-related decrease in natural killer cell activity in untreated patients with mycosis fungoides View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-11

AUTHORS

Salomon Levy, Jean-Louis Tempé, Patrick Caussade, Alexandre Aleksijevic, Edouard Grosshans, Simone Mayer, Jean-Marie Lang

ABSTRACT

Natural killer activity of peripheral blood mononuclear cells against the human cell line K 562 was evaluated in 11 patients with mycosis fungoides and simultaneously in 10 age- and sex-matched controls. In the patient group, nine had no previous treatment and in two topical therapy had been discontinued more than 3 months before. None had any associated disease or concurrent therapy that could interfere with the immune system. Patients with early disease showed a mean specific lysis and a range of individual data similar to the controls whereas patients with advanced disease had a significant defect of natural killer activity at effector: target ratios of 100 : 1, 50 : 1, and 25 : 1, as shown by the Mann-Whitney test. Preincubation of effector cells with alpha-interferon for 1 h in a single patient with low natural killing capacity led to a clear increase of the specific lysis, suggesting reduced functional activity rather than depletion of effector cells. More... »

PAGES

138-140

References to SciGraph publications

  • 1983-08. Natural Cell-Mediated Cytotoxicity in Cutaneous T-Cell Lymphomas in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00205749

    DOI

    http://dx.doi.org/10.1007/bf00205749

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1018943365

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6595055


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