Mapping of two new markers within the smallest interval harboring the spinal muscular atrophy locus by family and radiation hybrid ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-05

AUTHORS

Christina Brahe, Isabella Velonà, Gerrit van der Steege, Stefania Zappata, Anneke Y. van de Veen, Jan Osinga, Carli M. J. Tops, Riccardo Fodde, P. Meera Khan, Charles H. C. M. Buys, Giovanni Neri

ABSTRACT

The locus responsible for the childhood-onset proximal spinal muscular atrophies (SMA) has recently been mapped to an area of 2-3 Mb in the region q12-q13.3 of chromosome 5. We have used a series of radiation hybrids (RHs) containing distinct parts of the SMA region as defined by reference markers. A cosmid library was constructed from one RH. Thirteen clones were isolated and five of these were mapped within the SMA region. Both RH mapping and fluorescence in situ hybridization analysis showed that two clones map in the region between loci D5S125 and D5S351. One of the cosmids contains expressed sequences. Polymorphic dinucleotide repeats were identified in both clones and used for segregation analysis of key recombinant SMA families. One recombination between the SMA locus and the new marker 9Ic (D5S685) indicates that 9Ic is probably the closest distal marker. The absence of recombination between the SMA locus and marker Fc (D5S684) suggests that Fc is located close to the disease gene. These new loci should refine linkage analysis in SMA family studies and may facilitate the isolation of the disease gene. More... »

PAGES

494-501

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00202811

DOI

http://dx.doi.org/10.1007/bf00202811

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035767739

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8168823


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